Metabolism of Polycyclic Aromatic Hydrocarbon Derivatives to Ultimate Carcinogens During Lipid Peroxidation

[30] Microsomal lipid peroxidation

1978 • 12,818 citations

Lipid peroxidation damage to cell components.

1973 • 925 citations

Lipid peroxide formation in microsomes. General considerations

1969 • 528 citations

Chemicals, Drugs, and Lipid Peroxidation

1976 • 520 citations

ADP-activated lipid peroxidation coupled to the TPNH oxidase system of microsomes

1963 • 512 citations

Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.

1976 • 483 citations

Annual Review of Pharmacology,

1975 • 388 citations

Microsomal Electron Transport

1973 • 327 citations

Lipid peroxide formation in microsomes. The role of non-haem iron

1969 • 276 citations

Enzymatic conversion of benzo(a)pyrene leading predominantly to the diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene through a single enantiomer of r-7, t-8-dihydroxy-7,8-dihydrobenzo(a)pyrene.

1976 • 270 citations

Metabolism of benzo[a]pyrene VI. Stereoselective metabolism of benzo[a]pyrene and benzo[a]pyrene 7,8-dihydrodiol to diol epoxides

1977 • 263 citations

Marked differences in the skin tumor-initiating activities of the optical enantiomers of the diastereomeric benzo(a)pyrene 7,8-diol-9,10-epoxides.

1979 • 254 citations

Lipid peroxidation and the degradation of cytochrome P-450 heme

1973 • 224 citations

Autoxidation of fats and related substances

1954 • 218 citations

Release of enzymes from lysosomes by irradiation and the relation of lipid peroxide formation to enzyme release

1966 • 213 citations

Metabolism of benzo[a]pyrene: conversion of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides.

1976 • 206 citations

Inhibition of the TPNH-linked lipid peroxidation of liver microsomes by drugs undergoing oxidative demethylation

1964 • 191 citations

Activated metabolites of carcinogenic hydrocarbons

1981 • 142 citations

Oxidative Metabolism of Polycyclic Aromatic Hydrocarbons to Ultimate Carcinogens

1982 • 129 citations

Prostaglandin synthetase dependent activation of 7,8-dihydro-7,8-dihydroxy-benzo(a)pyrene to mutagenic derivatives

1978 • 117 citations

Microsomal metabolism of benzene to species irreversibly binding to microsomal protein and effects of modifications of this metabolism.

1978 • 105 citations

Effects of lipid peroxidation on activities of drug-metabolizing enzymes in liver microsomes of rats

1973 • 105 citations

Polycyclic aromatic hydrocarbon oxidation during prostaglandin biosynthesis

1981 • 104 citations

Regio- and stereoselectivity of various forms of purified cytochrome P -450 in the metabolism of benzo[ a ]pyrene and (-) trans -7,8-dihydroxy-7,8-dihydrobenzo[ a ]pyrene as shown by product formation and binding to DNA

1978 • 91 citations

Formation of “lipid peroxide” under conditions which lead to swelling and lysis of rat liver mitochondria

1962 • 83 citations

Free radical epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene by hematin and polyunsaturated fatty acid hydroperoxides

1981 • 80 citations

Arachidonic acid‐dependent metabolism of 7,8‐dihydroxy‐7,8‐dihydrobenzo[a]pyrene by ram seminal vesicles

1979 • 69 citations

Benzo(α)pyrene quinones can be generated by lipid peroxidation and are conjugated with glutathione by glutathione S-transferase B from rat liver

1981 • 60 citations

Arachidonic acid‐dependent metabolism of (±) trans‐7,8‐dihydroxy‐7,8‐ dihydro‐benzo[a]pyrene (BP‐7,8 diol) to 7,10/8,9 tetrols

1979 • 55 citations

Effects of linoleic acid hydroperoxide on the hepatic monooxygenase systems of microsomes from untreated, phenobarbital-treated, and 3-methylcholanthrene-treated rats.

1977 • 49 citations

Fungal oxidation of benzo[a]pyrene: Formation of (−)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene by Cunninghamella elegans

1980 • 33 citations

Stereoselectivity of the epoxidation of 7,8-dihydrobenzo[a]pyrene by prostaglandin H synthase and cytochrome P-450 determined by the identification of polyguanylic acid adducts.

1983 • 31 citations

Fungal oxidation of (+/-)-9,10-dihydroxy-9,10-dihydrobenzo[a]pyrene: formation of diastereomeric benzo[a]pyrene 9,10-diol 7,8-epoxides.

1980 • 23 citations

Metabolic Activation of 7,8-Dihydroxy-7,8-dihydrobenzo[a]-pyrene during Prostaglandin Biosynthesis

1982 • 21 citations

Irreversible binding of isolated benzo[a]pyrene metabolites to specific rat liver microsomal proteins.

1980 • 17 citations

A role for liver glutathione in the hepatobiliary fate of N,N-dimethyl-4-aminoazobenzene.

1979 • 13 citations