Surface Cytotoxic T Lymphocyte–associated Antigen 4 Partitions Within Lipid Rafts and Relocates to the Immunological Synapse under Conditions of Inhibition of T Cell Activation

Regulation of Renal Organic Anion Transporter 3 (SLC22A8) Expression and Function by the Integrity of Lipid Raft Domains and their Associated Cytoskeleton

2013 • 2,950 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

A new member of the immunoglobulin superfamily—CTLA-4

1987 • 1,214 citations

GPI-anchored proteins are organized in submicron domains at the cell surface

1998 • 1,207 citations

The Immunological Synapse

2001 • 987 citations

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

1999 • 964 citations

Membrane Compartmentation Is Required for Efficient T Cell Activation

1998 • 925 citations

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells.

1996 • 917 citations

LAT Palmitoylation

1998 • 837 citations

CD45: An Emerging Role as a Protein Tyrosine Phosphatase Required for Lymphocyte Activation and Development

1994 • 733 citations

Molecular Basis of T Cell Inactivation by CTLA-4

1998 • 678 citations

The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling

2000 • 657 citations

The Emerging Role of CTLA-4 as an Immune Attenuator

1997 • 637 citations

Intracellular Trafficking of CTLA-4 and Focal Localization Towards Sites of TCR Engagement

1996 • 583 citations

Selective modulation of protein kinase C-Θ during T-cell activation

1997 • 558 citations

Microdomains of GPI-anchored proteins in living cells revealed by crosslinking

1998 • 555 citations

CD80 (B7-1) Binds Both CD28 and CTLA-4 with a Low Affinity and Very Fast Kinetics

1997 • 525 citations

Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses

2001 • 459 citations

CTLA-4-Mediated Inhibition of Early Events of T Cell Proliferation

1999 • 412 citations

Lymphoproliferation in CTLA-4–Deficient Mice Is Mediated by Costimulation-Dependent Activation of CD4 + T Cells

1997 • 405 citations

Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signaling pathways in T lymphocytes

2000 • 338 citations

Tyrosine Phosphorylation Controls Internalization of CTLA-4 by Regulating Its Interaction with Clathrin-Associated Adaptor Complex AP-2

1997 • 334 citations

Structural basis for co-stimulation by the human CTLA-4/B7-2 complex

2001 • 333 citations

Antigen-induced translocation of PKC-θ to membrane rafts is required for T cell activation

2001 • 301 citations

Exclusion of CD43 from the Immunological Synapse Is Mediated by Phosphorylation-Regulated Relocation of the Cytoskeletal Adaptor Moesin

2001 • 270 citations

CTLA-4 (CD152) Can Inhibit T Cell Activation by Two Different Mechanisms Depending on Its Level of Cell Surface Expression

2000 • 259 citations

Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein

1997 • 182 citations

CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells.

1995 • 161 citations

Cytotoxic T Lymphocyte Antigen 4 (CTLA-4) Interferes with Extracellular Signal-regulated Kinase (ERK) and Jun NH2-terminal Kinase (JNK) Activation, but Does Not Affect Phosphorylation of T Cell Receptor ζ and ZAP70

1997 • 153 citations

Structure of Murine CTLA-4 and Its Role in Modulating T Cell Responsiveness

2000 • 144 citations

CTLA-4 ligation delivers a unique signal to resting human CD4 T cells that inhibits interleukin-2 secretion but allows Bcl-X(L) induction.

1998 • 137 citations

Cutting Edge: CTLA-4 Ligation Delivers a Unique Signal to Resting Human CD4 T Cells That Inhibits Interleukin-2 Secretion but Allows Bcl-XL Induction

1998 • 111 citations

Cytotoxic T Lymphocyte Antigen 4 (Ctla-4) Engagement Delivers an Inhibitory Signal through the Membrane-Proximal Region in the Absence of the Tyrosine Motif in the Cytoplasmic Tail

1999 • 96 citations

Inhibition of CTLA-4 Function by the Regulatory Subunit of Serine/Threonine Phosphatase 2A

2002 • 93 citations

Dissociation of Intracellular Signaling Pathways in Response to Partial Agonist Ligands of the T Cell Receptor

1998 • 92 citations

The Inhibitory Function of CTLA-4 Does Not Require Its Tyrosine Phosphorylation

2000 • 81 citations

Cutting Edge: Tyrosine-Independent Transmission of Inhibitory Signals by CTLA-4

2000 • 53 citations

FERMing Up the Synapse

2001 • 48 citations

Crystallization and functional analysis of a soluble deglycosylated form of the human costimulatory molecule B7-1

2001 • 19 citations

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