B7-H1 pathway and its role in the evasion of tumor immunity

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

2016 • 29,943 citations

Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review

2017 • 14,809 citations

Cancer immunoediting: from immunosurveillance to tumor escape

2002 • 4,911 citations

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

2002 • 4,625 citations

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

1992 • 2,906 citations

Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

2002 • 2,879 citations

Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes

2002 • 2,781 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 • 2,574 citations

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

1999 • 2,380 citations

Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

2001 • 1,761 citations

Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

1996 • 1,473 citations

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

1999 • 1,131 citations

Natural selection of tumor variants in the generation of “tumor escape” phenotypes

2002 • 1,014 citations

CTLA-4-Mediated Inhibition in Regulation of T Cell Responses: Mechanisms and Manipulation in Tumor Immunotherapy

2001 • 964 citations

Expression of Programmed Death 1 Ligands by Murine T Cells and APC

2002 • 908 citations

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

1997 • 886 citations

PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

2001 • 786 citations

A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans

2002 • 756 citations

A fresh look at tumor immunosurveillance and immunotherapy

2001 • 723 citations

Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia

2000 • 679 citations

PD-1:PD-L inhibitory pathway affects both CD4+ and CD8+ T cells and is overcome by IL-2

2002 • 646 citations

Ex Vivo Staining of Metastatic Lymph Nodes by Class I Major Histocompatibility Complex Tetramers Reveals High Numbers of Antigen-experienced Tumor-specific Cytolytic T Lymphocytes

1998 • 534 citations

Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses

1998 • 469 citations

Eradication of Established Tumors by CD8+ T Cell Adoptive Immunotherapy

2000 • 349 citations

B7-H1 Is Expressed by Human Endothelial Cells and Suppresses T Cell Cytokine Synthesis

2002 • 313 citations

Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues

2002 • 269 citations

Developmentally regulated expression of the PD-1 protein on the surface of double-negative(CD4^–CD8^–) thymocytes

1996 • 243 citations

B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function

2001 • 220 citations

High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins.

1994 • 200 citations

Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis

2003 • 185 citations

Facilitation of β Selection and Modification of Positive Selection in the Thymus of Pd-1–Deficient Mice

2000 • 181 citations

Gene therapy for cancer using single-chain Fv fragments specific for 4-1BB

2002 • 162 citations

Mucin gene (MUC1) transfected dendritic cells as vaccine: results of a phase I/II clinical trial

2002 • 157 citations

CD86 (B7-2) on Human B Cells

1997 • 120 citations

Heavy chain ferritin activates regulatory T cells by induction of changes in dendritic cells

2002 • 116 citations

The human PD-1 gene: complete cDNA, genomic organization, and developmentally regulated expression in B cell progenitors

1997 • 110 citations

B7 Family Molecules: Novel Immunomodulators at the Maternal-Fetal Interface

2002 • 110 citations

Human renal cell carcinoma antigen-specific CTLs: antigen-driven selection and long-term persistence in vivo.

1998 • 83 citations

Tuning tumor-specific T-cell activation: a matter of costimulation?

2002 • 78 citations

Vaccination against human cancers (review).

2000 • 73 citations

Microanatomical localization of PD-1 in human tonsils

2002 • 72 citations

Circulating MELAN-A/MART-1 specific cytolytic T lymphocyte precursors in HLA-A2+ melanoma patients have a memory phenotype

1998 • 67 citations

B7-1/CD80-transduced tumor cells elicit better systemic immunity than wild-type tumor cells admixed with Corynebacterium parvum.

1994 • 66 citations

T-Cell Adoptive Therapy of Tumors: Mechanisms of Improved Therapeutic Performance

2001 • 48 citations

Laser capture microdissection-based expression profiling identifies PD1-ligand as a target of the nude locus gene product

2001 • 42 citations

How much longer will tumour cells fool the immune system?

2000 • 41 citations

Tamura, H. et al. B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function. Blood 97, 1809-1816

2001 • 40 citations

Specific and nonspecific immunity in the prevention of spontaneous tumours

1999 • 21 citations

Circulating MELAN‐A/MART‐1 specific cytolytic T lymphocyte precursors in HLA‐A2 melanoma patients have a memory phenotype

1998 • 2 citations