Involvement of PP2A in viral and cellular transformation

THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES

1989 • 2,518 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1979 • 1,830 citations

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

1988 • 1,699 citations

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1988 • 1,490 citations

Spliced early mRNAs of simian virus 40

1978 • 817 citations

Regulation of protein kinase cascades by protein phosphatase 2A

1999 • 798 citations

Human papillomavirus immortalization and transformation functions

2002 • 758 citations

A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells

2004 • 750 citations

Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth

1993 • 662 citations

Enumeration of the Simian Virus 40 Early Region Elements Necessary for Human Cell Transformation

2002 • 604 citations

Regulation of Raf-1 by Direct Feedback Phosphorylation

2005 • 602 citations

Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter.

1988 • 595 citations

Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A

1990 • 586 citations

Species- and cell type-specific requirements for cellular transformation

2004 • 542 citations

The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation

1993 • 521 citations

STRUCTURE AND FUNCTION OF SIMIAN VIRUS 40 LARGE TUMOR ANTIGEN

1992 • 506 citations

Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases.

1996 • 499 citations

Post-translational regulation of the 54K cellular tumor antigen in normal and transformed cells.

1981 • 491 citations

Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors.

1996 • 490 citations

Function of simian virus 40 gene A in transforming infection

1975 • 447 citations

The Structure of the Protein Phosphatase 2A PR65/A Subunit Reveals the Conformation of Its 15 Tandemly Repeated HEAT Motifs

1999 • 434 citations

Regulation of β-Catenin Signaling by the B56 Subunit of Protein Phosphatase 2A

1999 • 423 citations

The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein.

1992 • 375 citations

Cellular transformation by SV40 large T antigen: interaction with host proteins

2001 • 361 citations

Alterations of the PPP2R1B Gene in Human Lung and Colon Cancer

1998 • 358 citations

Construction and analysis of viable deletion mutants of simian virus 40

1976 • 355 citations

Simian virus 40 functions required for the establishment and maintenance of malignant transformation

1975 • 354 citations

Role of simian virus 40 gene A function in maintenance of transformation

1975 • 321 citations

Identification of specific PP2A complexes involved in human cell transformation

2004 • 318 citations

The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus

1989 • 307 citations

A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle.

1995 • 305 citations

Protein Phosphatase 2A Positively Regulates Ras Signaling by Dephosphorylating KSR1 and Raf-1 on Critical 14-3-3 Binding Sites

2003 • 293 citations

Mutants of SV40 with an altered small t protein are reduced in their ability to transform cells

1978 • 284 citations

Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase

2003 • 277 citations

Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits

2002 • 268 citations

Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A

2004 • 261 citations

Identification of a Domain of Axin That Binds to the Serine/Threonine Protein Phosphatase 2A and a Self-binding Domain

1999 • 260 citations

In vitro mutagenesis of a putative DNA binding domain of SV40 large-T

1984 • 248 citations

Organization and expression of early genes of simian virus 40

1978 • 238 citations

.alpha.- And .beta.-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure

1990 • 236 citations

An N-Terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110 and a second cellular protein, p120

1989 • 235 citations

The Amino-Terminal Transforming Region of Simian Virus 40 Large T and Small t Antigens Functions as a J Domain

1997 • 226 citations

Association of protein phosphatase 2A with polyoma virus medium tumor antigen.

1990 • 221 citations

Identification of a New Family of Protein Phosphatase 2A Regulatory Subunits

1995 • 219 citations

Low frequency of alterations of the α (PPP2R1A) and β (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms

2000 • 212 citations

B cell receptor-associated protein α4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A

1997 • 212 citations

Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Cα

1998 • 210 citations

Induction of cyclin D1 by simian virus 40 small tumor antigen

1996 • 209 citations

Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform

1991 • 206 citations

Cyclin G Recruits PP2A to Dephosphorylate Mdm2

2002 • 205 citations

Identification of Kinase-Phosphatase Signaling Modules Composed of p70 S6 Kinase-Protein Phosphatase 2A (PP2A) and p21-activated Kinase-PP2A

1999 • 201 citations

Type 2A protein phosphatase, the complex regulator of numerous signaling pathways

2000 • 198 citations

The tumor-suppressive functions of the human INK4A locus

2003 • 192 citations

Saccharomyces cerevisiae protein phosphatase 2A performs an essential cellular function and is encoded by two genes.

1990 • 188 citations

Comparison of heterotrimeric protein phosphatase 2A containing different B subunits.

1994 • 187 citations

WD40 Repeat Proteins Striatin and S/G2 Nuclear Autoantigen Are Members of a Novel Family of Calmodulin-binding Proteins That Associate with Protein Phosphatase 2A

2000 • 185 citations

Cell-free translation of simian virus 40 early messenger RNA coding for viral T-antigen.

1977 • 181 citations

Recombinant retroviruses encoding simian virus 40 large T antigen and polyomavirus large and middle T antigens.

1986 • 178 citations

Inactivation of pRB-Related Proteins p130 and p107 Mediated by the J Domain of Simian Virus 40 Large T Antigen

1997 • 173 citations

Molecular cloning of cDNAs encoding two isoforms of the catalytic subunit of protein phosphatase 2A

1987 • 165 citations

High Complexity in the Expression of the B′ Subunit of Protein Phosphatase 2A0

1996 • 163 citations

CDC55, a Saccharomyces cerevisiae gene involved in cellular morphogenesis: identification, characterization, and homology to the B subunit of mammalian type 2A protein phosphatase.

1991 • 162 citations

A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation

2000 • 159 citations

Protein Phosphatase 2A Dephosphorylation of Phosphoserine 112 Plays the Gatekeeper Role for BAD-Mediated Apoptosis

2003 • 152 citations

Protein phosphatase 2A inactivates the mitogen-stimulated S6 kinase from Swiss mouse 3T3 cells.

1988 • 151 citations

Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen.

1991 • 149 citations

Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing

1993 • 149 citations

The J Domain of Simian Virus 40 Large T Antigen Is Required To Functionally Inactivate RB Family Proteins

1998 • 149 citations

The PP2A-Associated Protein α4 Is an Essential Inhibitor of Apoptosis

2004 • 148 citations

Resistance of human cells to tumorigenesis induced by cloned transforming genes.

1983 • 147 citations

Disruption of protein phosphatase 2A subunit interaction in human cancers with mutations in the Aα subunit gene

2001 • 144 citations

SV40 small t antigen enhances the transformation activity of limiting concentrations of SV40 large T antigen

1987 • 142 citations

Critical Role for Protein Phosphatase 2A Heterotrimers in Mammalian Cell Survival

2004 • 141 citations

Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens

1994 • 140 citations

Rescue of cells from ras oncogene-induced growth arrest by a second, complementing, oncogene.

1988 • 136 citations

Control of protein phosphatase 2A by simian virus 40 small-t antigen.

1991 • 134 citations

Interaction of adenoviral proteins with pRB and p53

1993 • 134 citations

Identification of binding sites on the regulatory A subunit of protein phosphatase 2A for the catalytic C subunit and for tumor antigens of simian virus 40 and polyomavirus.

1992 • 134 citations

Critical Role for SV40 Small-t Antigen in Human Cell Transformation

2001 • 131 citations

Protein phosphatase 2A subunit assembly: the catalytic subunit carboxy terminus is important for binding cellular B subunit but not polyomavirus middle tumor antigen

1997 • 130 citations

Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes.

1988 • 128 citations

Cardiac contractile protein phosphatases. Purification of two enzyme forms and their characterization with subunit-specific antibodies.

1987 • 125 citations

Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the Aβ subunit gene

2001 • 122 citations

Identification of a Novel Protein Phosphatase 2A Regulatory Subunit Highly Expressed in Muscle

1996 • 121 citations

PR48, a Novel Regulatory Subunit of Protein Phosphatase 2A, Interacts with Cdc6 and Modulates DNA Replication in Human Cells

2000 • 117 citations

Three distinct forms of type 2A protein phosphatase in human erythrocyte cytosol.

1988 • 116 citations

Comparisons of two early gene functions essential for transformation in polyoma virus and SV-40

1979 • 115 citations

Regulation of Protein Phosphatase 2A Catalytic Activity by alpha4 Protein and Its Yeast Homolog Tap42

1998 • 115 citations

Diversity in the Regulatory B-Subunits of Protein Phosphatase 2A: Identification of a Novel Isoform Highly Expressed in Brain

1994 • 113 citations

Drosophila mutants in the 55 kDa regulatory subunit of protein phosphatase 2A show strongly reduced ability to dephosphorylate substrates of p34cdc2

1994 • 107 citations

Protein phosphatase 2A1 is the major enzyme in vertebrate cell extracts that dephosphorylates several physiological substrates for cyclin-dependent protein kinases.

1993 • 106 citations

Large and small tumor antigens from simian virus 40 have identical amino termini mapping at 0.65 map units.

1978 • 105 citations

A novel simian virus 40 early-region domain mediates transactivation of the cyclin A promoter by small-t antigen and is required for transformation in small-t antigen-dependent assays

1996 • 104 citations

A recombinant murine retrovirus for simian virus 40 large T cDNA transforms mouse fibroblasts to anchorage-independent growth

1986 • 101 citations

Saccharomyces cerevisiae Homologs of Mammalian B and B′ Subunits of Protein Phosphatase 2A Direct the Enzyme to Distinct Cellular Functions

1997 • 100 citations

Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 protein

1999 • 99 citations

Transformation of a continuous rat embryo fibroblast cell line requires three separate domains of simian virus 40 large T antigen

1992 • 98 citations

SV40 Early mutants that are defective for viral DNA synthesis but competent for transformation of cultured rat and simian cells

1982 • 97 citations

Requirement for the simian virus 40 small tumor antigen in tumorigenesis in transgenic mice.

1988 • 96 citations

Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution

2003 • 94 citations

Alterations of the PPP2R1B gene located at 11q23 in human colorectal cancers

2000 • 91 citations

Characterization of the in Vitro interaction between SV40 T antigen and p53: Mapping the p53 binding site

1988 • 86 citations

Mutations which affect the inhibition of protein phosphatase 2A by simian virus 40 small-t antigen in vitro decrease viral transformation

1994 • 85 citations

Distinct role of protein phosphatase 2A subunit C α in the regulation of E-cadherin and β -catenin during development

2000 • 85 citations

Simian Virus 40 Small Tumor Antigen Activates AKT and Telomerase and Induces Anchorage-Independent Growth of Human Epithelial Cells

2002 • 82 citations

Cloning and characterization of Bδ, a novel regulatory subunit of protein phosphatase 2A

1999 • 81 citations

Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits.

1992 • 78 citations

Cellular proteins associated with simian virus 40 early gene products in newly infected cells

1979 • 77 citations

Role of small t antigen in the acute transforming activity of SV40

1982 • 76 citations

The structure of protein phosphatase 2A is as highly conserved as that of protein phosphatase I

1990 • 73 citations

PR72, a novel regulator of Wnt signaling required for Naked cuticle function

2005 • 73 citations

Abolition of Cyclin-Dependent Kinase Inhibitor p16^Ink4a and p21^Cip1/Waf1 Functions Permits Ras-Induced Anchorage-Independent Growth in Telomerase-Immortalized Human Fibroblasts

2003 • 71 citations

Cellular proteins that associate with the middle and small T antigens of polyomavirus

1988 • 69 citations

Inhibition of the Wnt Signaling Pathway by the PR61 Subunit of Protein Phosphatase 2A

2001 • 68 citations

Reduced expression of the A? subunit of protein phosphatase 2A in human gliomas in the absence of mutations in the A? and A? subunit genes

2001 • 60 citations

Activated Ha-ras can cooperate with defective simian virus 40 in the transformation of nonestablished rat embryo fibroblasts

1987 • 60 citations

Genomic Organisation, Chromosomal Localisation Tissue Distribution and Developmental Regulation of the PR61/B′ Regulatory Subunits of Protein Phosphatase 2A in Mice

2004 • 58 citations

A second catalytic subunit of type‐2A protein phosphatase from rabbit skeletal muscle

1987 • 57 citations

Crisis intervention: The role of telomerase

1999 • 55 citations

Signaling and Transcriptional Changes Critical for Transformation of Human Cells by Simian Virus 40 Small Tumor Antigen or Protein Phosphatase 2A B56γ Knockdown

2004 • 55 citations

Association of cellular 56,000- and 32,000-molecular-weight protein with BK virus and polyoma virus t-antigens

1981 • 54 citations

Transformation by purified early genes of simian virus 40

1984 • 51 citations

Molecular cloning and developmental expression of the catalytic and 65-kDa regulatory subunits of protein phosphatase 2A in Drosophila.

1992 • 50 citations

Differential requirement for SV40 early genes in immortalization and transformation of primary rat and human embryonic cells

1985 • 43 citations

Dephosphorylation of Bcl‐2 by protein phosphatase 2A results in apoptosis resistance

2004 • 40 citations

Role for PP2A in ARF signaling to p53

2004 • 40 citations

Identification of Structural Elements Involved in the Interaction of Simian Virus 40 Small Tumor Antigen with Protein Phosphatase 2A

1998 • 40 citations

The SV40 small t antigen is essential for the morphological transformation of human fibroblasts

1989 • 37 citations

The t-unique coding domain is important to the transformation maintenance function of the simian virus 40 small t antigen.

1986 • 37 citations

Requirement for the Simian Virus 40 Small Tumor Antigen in Tumorigenesis in Transgenic Mice

1988 • 34 citations

The protein phosphatase 2A subunit Bγ gene is identified to be differentially expressed in malignant melanomas by subtractive suppression hybridization

2001 • 29 citations

Homologous cellular proteins associated with simian virus 40 small T antigen and polyomavirus medium T antigen

1988 • 29 citations

Requirement of protein phosphatase 2A for recruitment of IQGAP1 to Rac‐bound β1 integrin

2004 • 24 citations

Absence of PPP2R1B gene alterations in primary ovarian cancers

1999 • 24 citations

Identification and characterization of B′′‐subunits of protein phosphatase 2 A in Xenopus laevis oocytes and adult tissues

2003 • 20 citations

Identification by differential display of a protein phosphatase-2A regulatory subunit preferentially expressed in malignant melanoma cells

1999 • 19 citations

Presence in growth-arrested cells of cellular proteins that interact with simian virus 40 small-t antigen

1982 • 6 citations