The J Domain of Simian Virus 40 Large T Antigen Is Required To Functionally Inactivate RB Family Proteins

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1988 • 1,490 citations

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

1992 • 1,031 citations

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

1994 • 772 citations

The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner

1992 • 588 citations

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.

1993 • 531 citations

Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

1994 • 493 citations

Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein

1991 • 464 citations

pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

1997 • 435 citations

Identification of a growth suppression domain within the retinoblastoma gene product.

1992 • 413 citations

E2F-4, a new member of the E2F transcription factor family, interacts with p107.

1994 • 331 citations

A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter.

1993 • 315 citations

Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members.

1995 • 299 citations

Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein

1990 • 295 citations

The molecular and cellular basis of affinity maturation in the antibody response

1992 • 278 citations

Binding to DNA and the Retinoblastoma Gene Product Promoted by Complex Formation of Different E2F Family Members

1993 • 271 citations

A Conserved HPD Sequence of the J-domain Is Necessary for YDJ1 Stimulation of Hsp70 ATPase Activity at a Site Distinct from Substrate Binding

1996 • 258 citations

Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes.

1995 • 254 citations

A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway.

1990 • 253 citations

Transcription of the E2F-1 Gene Is Rendered Cell Cycle Dependent by E2F DNA-Binding Sites within Its Promoter

1995 • 250 citations

In vitro mutagenesis of a putative DNA binding domain of SV40 large-T

1984 • 248 citations

A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites.

1995 • 248 citations

Common and unique features of T antigens encoded by the polyomavirus group

1992 • 235 citations

Two regions of the adenovirus early region 1A proteins are required for transformation

1988 • 232 citations

Eukaryotic DnaJ homologs and the specificity of Hsp70 activity

1993 • 228 citations

The Amino-Terminal Transforming Region of Simian Virus 40 Large T and Small t Antigens Functions as a J Domain

1997 • 226 citations

Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product.

1990 • 197 citations

DnaJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication.

1997 • 192 citations

The Transcription Factor E2F-1 Is a Downstream Target of RB Action

1995 • 190 citations

Inactivation of pRB-Related Proteins p130 and p107 Mediated by the J Domain of Simian Virus 40 Large T Antigen

1997 • 173 citations

The HIP1 Binding Site Is Required for Growth Regulation of the Dihydrofolate Reductase Gene Promoter

1992 • 172 citations

The T/t common exon of simian virus 40, JC, and BK polyomavirus T antigens can functionally replace the J-domain of the Escherichia coli DnaJ molecular chaperone

1997 • 152 citations

Association of p53 binding and immortalization of primary C57BL/6 mouse embryo fibroblasts by using simian virus 40 T-antigen mutants bearing internal overlapping deletion mutations

1993 • 147 citations

Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes.

1993 • 141 citations

Regions of the Retinoblastoma Gene Product Required for its Interaction with the E2F Transcription Factor are Necessary for E2 Promoter Repression and pRb-Mediated Growth Suppression

1993 • 140 citations

Role of pRb-Related Proteins in Simian Virus 40 Large-T-Antigen-Mediated Transformation

1995 • 139 citations

The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes.

1995 • 135 citations

Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinoma

1997 • 129 citations

Cell cycle-dependent phosphorylation of the retinoblastoma-related protein p130.

1995 • 129 citations

The large tumor antigen of simian virus 40 encodes at least two distinct transforming functions

1989 • 117 citations

Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit.

1996 • 115 citations

Adenovirus E1A makes two distinct contacts with the retinoblastoma protein

1992 • 113 citations

Identification of distinct roles for separate E1A domains in disruption of E2F complexes.

1993 • 113 citations

Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases.

1996 • 110 citations

Functional analysis of pRb2/p130 interaction with cyclins.

1996 • 109 citations

Simian virus 40 large T antigen alters the phosphorylation state of the RB-related proteins p130 and p107

1996 • 100 citations

Association of a cellular heat shock protein with simian virus 40 large T antigen in transformed cells

1989 • 99 citations

Transformation of a continuous rat embryo fibroblast cell line requires three separate domains of simian virus 40 large T antigen

1992 • 98 citations

Dissociation of Rb-binding and anchorage-independent growth from immortalization and tumorigenicity using SV40 mutants producing N-terminally truncated large T antigens

1990 • 95 citations

Mutants with changes within or near a hydrophobic region of simian virus 40 large tumor antigen are defective for binding cellular protein p53

1989 • 94 citations

A Protein Synthesis-Dependent Increase in E2F1 mRNA Correlates with Growth Regulation of the Dihydrofolate Reductase Promoter

1993 • 80 citations

Transcription of the E2F-1 Gene Is Rendered Cell Cycle Dependent by E2F DNA-Binding Sites within Its Promoter

1994 • 71 citations

Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes

1997 • 60 citations

Transcriptional Repression and Growth Suppression by the p107 Pocket Protein

1996 • 54 citations

Definition of the Minimal Simian Virus 40 Large Τ Antigen- and Adenovirus E1A-Binding Domain in the Retinoblastoma Gene Product

1990 • 54 citations

Independent Regions of Adenovirus E1A are Required for Binding to and Dissociation of E2F-Protein Complexes

1993 • 47 citations

Simian virus 40 small tumor antigen and an amino-terminal domain of large tumor antigen share a common transforming function.

1990 • 46 citations

Inactivation of the retinoblastoma susceptibility protein is not sufficient for the transforming function of the conserved region 2-like domain of simian virus 40 large T antigen

1995 • 36 citations