PR72, a novel regulator of Wnt signaling required for Naked cuticle function

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

2002 • 4,334 citations

Wnt signaling and cancer

2000 • 3,215 citations

Wnt signaling: a common theme in animal development

1997 • 2,579 citations

β-catenin is a target for the ubiquitin–proteasome pathway

1997 • 2,461 citations

High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier

1989 • 2,140 citations

Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway

2002 • 1,601 citations

Caught up in a Wnt storm: Wnt signaling in cancer

2003 • 1,473 citations

The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

1993 • 1,459 citations

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -catenin

1998 • 1,244 citations

Armadillo Coactivates Transcription Driven by the Product of the Drosophila Segment Polarity Gene dTCF

1997 • 1,201 citations

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3.

1996 • 1,156 citations

Stable suppression of tumorigenicity by virus-mediated RNA interference

2002 • 1,147 citations

Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors

2002 • 1,014 citations

The Wnt/Ca2+ pathway

2000 • 843 citations

Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway

2001 • 826 citations

Regulation of protein kinase cascades by protein phosphatase 2A

1999 • 798 citations

Wnt-3a regulates somite and tailbud formation in the mouse embryo.

1994 • 784 citations

Dishevelled Activates JNK and Discriminates between JNK Pathways in Planar Polarity and wingless Signaling

1998 • 774 citations

Dishevelled controls cell polarity during Xenopus gastrulation

2000 • 750 citations

Shaping the Vertebrate Body Plan by Polarized Embryonic Cell Movements

2002 • 718 citations

Mechanism and function of signal transduction by the Wnt/β-catenin and Wnt/Ca2+ pathways

1999 • 699 citations

Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways

1998 • 642 citations

The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF

1999 • 613 citations

Wnt3a Plays a Major Role in the Segmentation Clock Controlling Somitogenesis

2003 • 588 citations

Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation

2003 • 580 citations

Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun.

1992 • 531 citations

pangolinencodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila

1997 • 494 citations

Regulation of β-Catenin Signaling by the B56 Subunit of Protein Phosphatase 2A

1999 • 423 citations

The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal.

1994 • 407 citations

DIX Domains of Dvl and Axin Are Necessary for Protein Interactions and Their Ability To Regulate β-Catenin Stability

1999 • 396 citations

Alterations of the PPP2R1B Gene in Human Lung and Colon Cancer

1998 • 358 citations

Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/β-catenin signaling is activated in human colon tumors

2001 • 355 citations

Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos

2003 • 337 citations

dishevelled is required during wingless signaling to establish both cell polarity and cell identity

1994 • 335 citations

[75] Assay of transforming activity of tumor virus DNA

1980 • 331 citations

From cortical rotation to organizer gene expression: toward a molecular explanation of axis specification in Xenopus

1998 • 321 citations

Runnin' with the Dvl: Proteins That Associate with Dsh/Dvl and Their Significance to Wnt Signal Transduction

2003 • 308 citations

Dishevelled: at the crossroads of divergent intracellular signaling pathways

1999 • 267 citations

Establishment of the Dorsal–Ventral Axis inXenopus Embryos Coincides with the Dorsal Enrichment of Dishevelled That Is Dependent on Cortical Rotation

1999 • 255 citations

naked cuticle encodes an inducible antagonist of Wnt signalling

2000 • 221 citations

Segmentation in vertebrates: clock and gradient finally joined

2004 • 217 citations

Head in the WNT: the molecular nature of Spemann’s head organizer

1999 • 202 citations

The molecular nature of the zebrafish tail organizer

2003 • 202 citations

Frizzled signaling and the developmental control of cell polarity

1998 • 183 citations

Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite

2001 • 171 citations

Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd

2001 • 165 citations

naked cuticle targets dishevelled to antagonize Wnt signal transduction

2001 • 158 citations

Move it or lose it: axis specification in Xenopus

2004 • 154 citations

Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus

2001 • 152 citations

Ectopic Wnt signal determines the eyeless phenotype of zebrafishmasterblindmutant

2001 • 152 citations

Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing

1993 • 149 citations

Vertebrate Proteins Related to Drosophila Naked Cuticle Bind Dishevelled and Antagonize Wnt Signaling

2001 • 140 citations

A Role for WNT Proteins in Induction of Dermomyotome

1997 • 137 citations

Negative Feedback Mechanisms and Their Roles during Pattern Formation

1999 • 127 citations

HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cells

2003 • 124 citations

Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the Aβ subunit gene

2001 • 122 citations

Role of PP2A in intracellular signal transduction pathways

1998 • 116 citations

Wnt Activates the Tak1/Nemo-like Kinase Pathway

2004 • 108 citations

Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 protein

1999 • 99 citations

PP2A:B56ϵ is required for Wnt/β-catenin signaling during embryonic development

2003 • 88 citations

Identification and Functional Analysis of Two Ca2+-binding EF-hand Motifs in the B“/PR72 Subunit of Protein Phosphatase 2A

2003 • 85 citations

Differential expression of the HMG box transcription factors XTcf-3 and XLef-1 during early Xenopus development

1998 • 78 citations

Isolation of theXenopusbomolog ofint-1/winglessand expression during neurula stages of early development

1989 • 73 citations

Zinc-dependent Interaction between Dishevelled and the Drosophila Wnt Antagonist Naked Cuticle

2002 • 36 citations

The Spemann-Mangold organizer: the control of fate specification and morphogenetic rearrangements during gastrulation in Xenopus.

2001 • 28 citations