Crisis intervention: The role of telomerase

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

1997 • 2,256 citations

The RNA Component of Human Telomerase

1995 • 2,243 citations

Telomere length predicts replicative capacity of human fibroblasts.

1992 • 2,209 citations

Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

1997 • 2,086 citations

hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization

1997 • 1,786 citations

A theory of marginotomy

1973 • 1,770 citations

TRF2 Protects Human Telomeres from End-to-End Fusions

1998 • 1,679 citations

Telomere reduction in human colorectal carcinoma and with ageing

1990 • 1,672 citations

Origin of Concatemeric T7DNA

1972 • 1,591 citations

Essential role of mouse telomerase in highly proliferative organs

1998 • 1,256 citations

Control of telomere length by the human telomeric protein TRF1

1997 • 1,197 citations

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

1998 • 1,001 citations

Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

1997 • 946 citations

Absence of cancer–associated changes in human fibroblasts immortalized with telomerase

1999 • 798 citations

Telomerase activity in normal and malignant hematopoietic cells.

1995 • 748 citations

A role for both RB and p53 in the regulation of human cellular senescence*1

1991 • 737 citations

Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype

1999 • 658 citations

Myc activates telomerase

1998 • 650 citations

Single-Stranded DNA Arising at Telomeres in cdc13 Mutants May Constitute a Specific Signal for the RAD9 Checkpoint

1995 • 632 citations

Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

1998 • 629 citations

Sugar and Disease

1972 • 532 citations

A Protein-Counting Mechanism for Telomere Length Regulation in Yeast

1997 • 514 citations

Yeast Ku as a Regulator of Chromosomal DNA End Structure

1998 • 432 citations

Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase

1998 • 419 citations

Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening

1999 • 384 citations

Reconstitution of human telomerase activity in vitro

1998 • 347 citations

Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis

1996 • 291 citations

Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1

1991 • 257 citations

The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities

1998 • 245 citations

Three Ever Shorter Telomere ( EST ) genes are dispensable for in vitro yeast telomerase activity

1997 • 233 citations

Variability at the Telomeres of the Human X/Y Pseudoautosomal Region

1986 • 229 citations

Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase.

1996 • 226 citations

Amplification, increased dosage and in situ expression of the telomerase RNA gene in human cancer

1997 • 179 citations

Expression of SV40 large T antigen, but not small t antigen, is required for the induction of chromosomal aberrations in transformed human cells

1991 • 156 citations