Protein Phosphatase 2A Dephosphorylation of Phosphoserine 112 Plays the Gatekeeper Role for BAD-Mediated Apoptosis

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

1999 • 1,897 citations

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

2001 • 1,654 citations

The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity

1997 • 1,592 citations

Interaction of 14-3-3 with Signaling Proteins Is Mediated by the Recognition of Phosphoserine

1996 • 1,371 citations

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

2001 • 1,268 citations

Ca ²⁺ -Induced Apoptosis Through Calcineurin Dephosphorylation of BAD

1999 • 1,136 citations

BH3-Only Proteins—Essential Initiators of Apoptotic Cell Death

2000 • 1,033 citations

Life-or-death decisions by the Bcl-2 protein family

2001 • 887 citations

How do 14‐3‐3 proteins work? – Gatekeeper phosphorylation and the molecular anvil hypothesis

2001 • 659 citations

Phosphorylation and Inactivation of BAD by Mitochondria-Anchored Protein Kinase A

1999 • 635 citations

14-3-3 Proteins and Survival Kinases Cooperate to Inactivate BAD by BH3 Domain Phosphorylation

2000 • 634 citations

p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

2001 • 540 citations

14-3-3 Proteins: Active Cofactors in Cellular Regulation by Serine/Threonine Phosphorylation

2002 • 496 citations

Phosphorylation of Bcl2 and regulation of apoptosis

2001 • 453 citations

Control of Apoptosis in the Immune System: Bcl-2, BH3-Only Proteins and More

2003 • 387 citations

p21-Activated Kinase 1 Phosphorylates the Death Agonist Bad and Protects Cells from Apoptosis

2000 • 356 citations

14-3-3 Interacts Directly with and Negatively Regulates Pro-apoptotic Bax

2003 • 344 citations

Phosphorylation of Bid by Casein Kinases I and II Regulates Its Cleavage by Caspase 8

2001 • 341 citations

Ceramide Induces Bcl2 Dephosphorylation via a Mechanism Involving Mitochondrial PP2A

1999 • 340 citations

Isolation of High-Affinity Peptide Antagonists of 14-3-3 Proteins by Phage Display

1999 • 305 citations

BAD Ser-155 Phosphorylation Regulates BAD/Bcl-XL Interaction and Cell Survival

2000 • 304 citations

Rsk1 mediates a MEK–MAP kinase cell survival signal

2000 • 290 citations

The CD28 and CTLA-4 Receptors Associate with the Serine/Threonine Phosphatase PP2A

2000 • 287 citations

Cdc2 Phosphorylation of BAD Links the Cell Cycle to the Cell Death Machinery

2002 • 285 citations

Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155

2000 • 275 citations

Survival Factor-Mediated BAD Phosphorylation Raises the Mitochondrial Threshold for Apoptosis

2002 • 270 citations

p90RSK Blocks Bad-mediated Cell Death via a Protein Kinase C-dependent Pathway

1999 • 234 citations

Growth Factors Inactivate the Cell Death Promoter BAD by Phosphorylation of Its BH3 Domain on Ser155

2000 • 225 citations

Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A

1997 • 207 citations

Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155

2000 • 181 citations

Specificity of 14-3-3 isoform dimer interactions and phosphorylation

2002 • 168 citations

14-3-3 Inhibits Bad-Induced Cell Death through Interaction with Serine-136

2001 • 159 citations

Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3–dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation

2001 • 151 citations

14-3-3 Is Phosphorylated by Casein Kinase I on Residue 233

1997 • 146 citations

Protein Kinase C θ and ε Promote T-cell Survival by a Rsk-dependent Phosphorylation and Inactivation of BAD

2000 • 136 citations

Protein phosphatase 1α is a Ras-activated Bad phosphatase that regulates interleukin-2 deprivation-induced apoptosis

2000 • 136 citations

14-3-3 Isotypes facilitate coupling of protein kinase C-ζ to Raf-1: negative regulation by 14-3-3 phosphorylation

2000 • 129 citations

Survival-promoting functions of 14-3-3 proteins

2002 • 109 citations

Role of the BH3 (Bcl-2 homology 3) domain in the regulation of apoptosis and Bcl-2-related proteins

2000 • 104 citations

Phosphorylation of the Pro-apoptotic Protein BIK

2001 • 101 citations

Purification of protein phosphatase 4 catalytic subunit: inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters

1998 • 97 citations

Identification of a Novel Phosphorylation Site, Ser-170, as a Regulator of Bad Pro-apoptotic Activity

2002 • 78 citations

Versatility of BCR/ABL-expressing leukemic cells in circumventing proapoptotic BAD effects

2000 • 71 citations

14-3-3 Isotypes facilitate coupling of protein kinase C-ζ to Raf-1: negative regulation by 14-3-3 phosphorylation

2000 • 67 citations

Versatility of BCR/ABL-expressing leukemic cells in circumventing proapoptotic BAD effects

2000 • 23 citations

The growth-promoting activity of the Bad protein in chicken embryo fibroblasts requires binding to protein 14-3-3

2001 • 23 citations