Type 2A protein phosphatase, the complex regulator of numerous signaling pathways

The Genome Sequence of Drosophila melanogaster

2000 • 5,882 citations

THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES

1989 • 2,518 citations

Liver Failure and Death after Exposure to Microcystins at a Hemodialysis Center in Brazil

1998 • 1,082 citations

On target with a new mechanism for the regulation of protein phosphorylation

1993 • 901 citations

Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1

1995 • 850 citations

Regulation of protein kinase cascades by protein phosphatase 2A

1999 • 798 citations

Serine/threonine protein phosphatases

1995 • 635 citations

AKAPs: from structure to function

1999 • 619 citations

Novel protein serine/threonine phosphatases: Variety is the spice of life

1997 • 503 citations

Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases.

1996 • 499 citations

The Myeloid Leukemia-associated Protein SET Is a Potent Inhibitor of Protein Phosphatase 2A

1996 • 463 citations

The Structure of the Protein Phosphatase 2A PR65/A Subunit Reveals the Conformation of Its 15 Tandemly Repeated HEAT Motifs

1999 • 434 citations

Protein Serine/Threonine Phosphatases—New Avenues for Cell Regulation

1994 • 424 citations

Regulation of β-Catenin Signaling by the B56 Subunit of Protein Phosphatase 2A

1999 • 423 citations

The B56 Family of Protein Phosphatase 2A (PP2A) Regulatory Subunits Encodes Differentiation-induced Phosphoproteins That Target PP2A to Both Nucleus and Cytoplasm

1996 • 371 citations

Molecular mechanisms of theprotein serine/threonine phosphatases

1996 • 365 citations

Alterations of the PPP2R1B Gene in Human Lung and Colon Cancer

1998 • 358 citations

Ceramide Induces Bcl2 Dephosphorylation via a Mechanism Involving Mitochondrial PP2A

1999 • 340 citations

Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast

1999 • 339 citations

Tumor Promotion by Inhibitors of ProteinZ Phosphatases 1 and 2A: The Okadaic Acid Class of Compounds

1993 • 310 citations

A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle.

1995 • 305 citations

Differential Inhibition and Posttranslational Modification of Protein Phosphatase 1 and 2A in MCF7 Cells Treated with Calyculin-A, Okadaic Acid, and Tautomycin

1997 • 304 citations

Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation.

1993 • 301 citations

The Yeast Proteome Database (YPD) and Caenorhabditis elegans Proteome Database (WormPD): comprehensive resources for the organization and comparison of model organism protein information

2000 • 290 citations

Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction.

1994 • 288 citations

The protein kinases of Caenorhabditis elegans : A model for signal transduction in multicellular organisms

1999 • 277 citations

CDC55, a Saccharomyces cerevisiae Gene Involved in Cellular Morphogenesis: Identification, Characterization, and Homology to the B Subunit of Mammalian Type 2A Protein Phosphatase

1991 • 276 citations

Inhibitors of protein kinases and phosphatases

1994 • 268 citations

A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus.

1994 • 261 citations

Identification of a Domain of Axin That Binds to the Serine/Threonine Protein Phosphatase 2A and a Self-binding Domain

1999 • 260 citations

Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts.

1994 • 251 citations

Characterization of a Novel Giant Scaffolding Protein, CG-NAP, That Anchors Multiple Signaling Enzymes to Centrosome and the Golgi Apparatus

1999 • 239 citations

.alpha.- And .beta.-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure

1990 • 236 citations

The 55 kd regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase

1993 • 215 citations

Purification and Characterization of Two Potent Heat-Stable Protein Inhibitors of Protein Phosphatase 2A from Bovine Kidney

1995 • 214 citations

Low frequency of alterations of the α (PPP2R1A) and β (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms

2000 • 212 citations

B cell receptor-associated protein α4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A

1997 • 212 citations

Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Cα

1998 • 210 citations

HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint

1997 • 195 citations

Protein phosphatase 2A catalytic subunit is methyl-esterified at its carboxyl terminus by a novel methyltransferase.

1993 • 187 citations

A Protein Phosphatase Methylesterase (PME-1) Is One of Several Novel Proteins Stably Associating with Two Inactive Mutants of Protein Phosphatase 2A

1999 • 186 citations

WD40 Repeat Proteins Striatin and S/G2 Nuclear Autoantigen Are Members of a Novel Family of Calmodulin-binding Proteins That Associate with Protein Phosphatase 2A

2000 • 185 citations

GSK-3β-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by β-catenin and protein phosphatase 2A complexed with Axin

2000 • 177 citations

The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity.

1995 • 176 citations

α4 Associates with Protein Phosphatases 2A, 4, and 6

1998 • 175 citations

Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Bα subunit

1999 • 173 citations

Protein phosphorylation and protein phosphatasesDe Panne, Belgium, September 19–24, 1999

2000 • 172 citations

The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo.

1994 • 170 citations

Separation of PP2A Core Enzyme and Holoenzyme with Monoclonal Antibodies against the Regulatory A Subunit: Abundant Expression of Both Forms in Cells

1997 • 164 citations

CDC55, a Saccharomyces cerevisiae gene involved in cellular morphogenesis: identification, characterization, and homology to the B subunit of mammalian type 2A protein phosphatase.

1991 • 162 citations

Autophosphorylation-activated protein kinase phosphorylates and inactivates protein phosphatase 2A.

1993 • 159 citations

Induction of apoptosis by adenovirus E4orf4 protein is specific to transformed cells and requires an interaction with protein phosphatase 2A

1999 • 146 citations

Purification of Porcine Brain Protein Phosphatase 2A Leucine Carboxyl Methyltransferase and Cloning of the Human Homologue^,

1999 • 143 citations

Protein phosphatase 2A: Who shall regulate the regulator?

1999 • 142 citations

Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens

1994 • 140 citations

Inhibition of protein phosphatase 2A induces serine/threonine phosphorylation, subcellular redistribution, and functional inhibition of STAT3

1999 • 134 citations

Identification of binding sites on the regulatory A subunit of protein phosphatase 2A for the catalytic C subunit and for tumor antigens of simian virus 40 and polyomavirus.

1992 • 134 citations

Cdc55p, the B-Type Regulatory Subunit of Protein Phosphatase 2A, Has Multiple Functions in Mitosis and Is Required for the Kinetochore/Spindle Checkpoint in Saccharomyces cerevisiae

1997 • 131 citations

Protein phosphatase 2A is reversibly modified by methyl esterification at its C-terminal leucine residue in bovine brain.

1994 • 122 citations

Expression of a peptide inhibitor of protein phosphatase 1 increases phosphorylation and activity of CREB in NIH 3T3 fibroblasts.

1994 • 122 citations

PR48, a Novel Regulatory Subunit of Protein Phosphatase 2A, Interacts with Cdc6 and Modulates DNA Replication in Human Cells

2000 • 117 citations

Regulation of Protein Phosphatase 2A Catalytic Activity by alpha4 Protein and Its Yeast Homolog Tap42

1998 • 115 citations

Different oligomeric forms of protein phosphatase 2A activate and inhibit simian virus 40 DNA replication.

1994 • 109 citations

Distinct Roles for PP1 and PP2A in Phosphorylation of the Retinoblastoma Protein

1999 • 106 citations

Protein phosphatase 2A1 is the major enzyme in vertebrate cell extracts that dephosphorylates several physiological substrates for cyclin-dependent protein kinases.

1993 • 106 citations

Vimentin Dephosphorylation by Protein Phosphatase 2A Is Modulated by the Targeting Subunit B55

1999 • 100 citations

Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 protein

1999 • 99 citations

Purification of protein phosphatase 4 catalytic subunit: inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters

1998 • 97 citations

Spatiotemporal distribution of protein kinase and phosphatase activities

1994 • 93 citations

Protein serine/threonine phosphatases and cell transformation

1993 • 92 citations

Protein phosphatase 2A is required for the initiation of chromosomal DNA replication

1998 • 90 citations

Regulation of Angiotensin II-induced Phosphorylation of STAT3 in Vascular Smooth Muscle Cells

1999 • 90 citations

Cloning and characterization of Bδ, a novel regulatory subunit of protein phosphatase 2A

1999 • 81 citations

The Dimeric and Catalytic Subunit Forms of Protein Phosphatase 2A from Rat Brain Are Stimulated by C2-Ceramide

1995 • 81 citations

The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits

1996 • 77 citations

Protein Phosphatase 2A Potentiates Activity of Promoters Containing AP-1-Binding Elements

1993 • 77 citations

Expression of I2PP2A, an inhibitor of protein phosphatase 2A, induces c-Jun and AP-1 activity

1999 • 76 citations

The catalytic subunit of protein phosphatase 2A associates with the translation termination factor eRF1.

1996 • 76 citations

Molecular cloning, expression, and characterization of PTPA, a protein that activates the tyrosyl phosphatase activity of protein phosphatase 2A.

1994 • 72 citations

A mutant of protein phosphatase-1 that exhibits altered toxin sensitivity.

1994 • 71 citations

Alpha4 protein as a common regulator of type 2A‐related serine/threonine protein phosphatases¹

1999 • 65 citations

A Yeast Homologue of the Human Phosphotyrosyl Phosphatase Activator PTPA Is Implicated in Protection against Oxidative DNA Damage Induced by the Model Carcinogen 4-Nitroquinoline 1-Oxide

1998 • 63 citations

Protein Phosphatase 2A and Phosphatidylinositol 3-Kinase Regulate the Activity of Sp1-responsive Promoters

2000 • 60 citations

Isolation and partial characterization of an Mr 60,000 subunit of a type 2A phosphatase from rabbit reticulocytes

1989 • 59 citations

The Arabidopsis Homolog of Yeast TAP42 and Mammalian α4 Binds to the Catalytic Subunit of Protein Phosphatase 2A and Is Induced by Chilling

1999 • 52 citations

Phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin

1999 • 51 citations

Phosphatase 2A associated with polyomavirus small-T or middle-T antigen is an okadaic acid-sensitive tyrosyl phosphatase

1993 • 51 citations

Transient Translocation and Activation of Protein Phosphatase 2A during Mast Cell Secretion

2000 • 50 citations

Simian virus 40 small tumor antigen inhibits dephosphorylation of protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation.

1994 • 50 citations

Protein Phosphatase 2A Inhibitors, I1PP2A and I2PP2A, Associate with and Modify the Substrate Specificity of Protein Phosphatase 1

2000 • 50 citations

Direct activation of protein phosphatase‐2A₀ by HIV‐1 encoded protein complex NCp7:vpr

1997 • 49 citations

Cytostatin, an inhibitor of cell adhesion to extracellular matrix, selectively inhibits protein phosphatase 2A

1999 • 49 citations

Human cytomegalovirus carries serine/threonine protein phosphatases PP1 and a host-cell derived PP2A

1996 • 48 citations

Protein phosphatase 2A is associated in an inactive state with microtubules through 2A1-specific interaction with tubulin

2000 • 47 citations

Characterization of the PP2A alpha gene mutation in okadaic acid-resistant variants of CHO-K1 cells.

1994 • 46 citations

Protein phosphatase 2A potentiates activity of promoters containing AP-1-binding elements.

1993 • 44 citations

Regulation of gene expression by serine/threonine protein phosphatases

1995 • 38 citations

An anchoring factor targets protein phosphatase 2A to brain microtubules

1999 • 33 citations

Microcystin affinity purification of plant protein phosphatases: PP1C, PP5 and a regulatory A‐subunit of PP2A

1999 • 30 citations

Direct metal analyses of Mn²⁺‐dependent and ‐independent protein phosphatase 2A from human erythrocytes detect zinc and iron only in the Mn²⁺‐independent one

1999 • 23 citations

Eukaryotic translation termination factor 1 associates with protein phosphatase 2A and targets it to ribosomes.

1999 • 16 citations

The apoptosis-inducing activity of the two protein phosphatase inhibitors, tautomycin and thyrsiferyl 23-acetate, is not due to the inhibition of protein phosphatases PP1 and PP2A (review).

1999 • 7 citations

Analysis by in Vitro Mutagenesis of PP2Aα Okadaic Acid Responsive Sequences

1995 • 6 citations

Deleted Work

1955 • 0 citations