Reduced BDNF mRNA Expression in the Parkinson's Disease Substantia Nigra

Brain dopamine and the syndromes of Parkinson and Huntington Clinical, morphological and neurochemical correlations

1973 • 2,615 citations

BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra

1991 • 1,487 citations

What features improve the accuracy of clinical diagnosis in Parkinson's disease

1992 • 1,232 citations

Functional recovery in parkinsonian monkeys treated with GDNF

1996 • 955 citations

A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and alzheimer disease

1981 • 698 citations

Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system

1992 • 592 citations

Activated Macrophages and Microglia Induce Dopaminergic Sprouting in the Injured Striatum and Express Brain-Derived Neurotrophic Factor and Glial Cell Line-Derived Neurotrophic Factor

1999 • 569 citations

Rate of cell death in parkinsonism indicates active neuropathological process

1988 • 545 citations

Direct Comparison of GAPDH, β-Actin, Cyclophilin, and 28S rRNA as Internal Standards for Quantifying RNA Levels under Hypoxia

1999 • 466 citations

Brain‐Derived Neurotrophic Factor Protects Dopamine Neurons Against 6‐Hydroxydopamine and N‐Methyl‐4‐Phenylpyridinium Ion Toxicity: Involvement of the Glutathione System

1992 • 465 citations

Adrenal Medulla Grafts Enhance Recovery of Striatal Dopaminergic Fibers

1987 • 398 citations

Molecular cloning of a human gene that is a member of the nerve growth factor family.

1990 • 397 citations

Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease

1999 • 382 citations

Tissue pH as an indicator of mRNA preservation in human post-mortem brain

1995 • 318 citations

Neurotrophin trafficking by anterograde transport

1998 • 317 citations

Reduced expression of brain-derived neurotrophic factor protein in Parkinsonʼs disease substantia nigra

1999 • 292 citations

Dopaminergic neurons in rat ventral midbrain express brain‐derived neurotrophic factor and neurotrophin‐3 mRNAs

1994 • 290 citations

Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease

1995 • 269 citations

Research diagnostic criteria for Parkinson's disease.

1990 • 267 citations

Adrenal medullary autografts into the basal ganglia of Cebus monkeys: Injury-induced regeneration

1988 • 205 citations

Glial Cell Line‐Derived Neurotrophic Factor Exerts Neurotrophic Effects on Dopaminergic Neurons In Vitro and Promotes Their Survival and Regrowth After Damage by 1‐Methyl‐4‐Phenylpyridinium

1996 • 181 citations

Expression of members of the trk family in the developing postnatal rat brain

1993 • 174 citations

Putative chromaffin cell survival and enhanced host‐derived TH‐Fiber innervation following a functional adrenal medulla autograft for Parkinson's disease

1991 • 159 citations

BDNF Enhances the Functional Reinnervation of the Striatum by Grafted Fetal Dopamine Neurons

1996 • 141 citations

Effects of Brain-derived Neurotrophic Factor on 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in Monkeys

1995 • 138 citations

Dopaminergic stimulation up‐regulates the in vivo expression of brain‐derived neurotrophic factor (BDNF) in the striatum

1992 • 136 citations

Does adrenal graft enhance recovery of dopaminergic neurons in Parkinson's disease?

1990 • 133 citations

Long-term evaluation of hemiparkinsonian monkeys after adrenal autografting or cavitation alone

1990 • 127 citations

Nuclear Translocation of Glyceraldehyde‐3‐Phosphate Dehydrogenase Isoforms During Neuronal Apoptosis

1999 • 125 citations

Brain-derived neurotrophic factor and neurotrophin-3 mRNAs are expressed in ventral midbrain regions containing dopaminergic neurons

1992 • 123 citations

Glial cell line-derived neurotrophic factor (GDNF) gene expression in the human brain: A post mortem in situ hybridization study with special reference to Parkinson's disease

1996 • 94 citations

β‐Actin is confined to structures having high capacity of remodelling in developing and adult rat cerebellum

1998 • 87 citations

BDNF attenuates the effects of intrastriatal injection of 6-hydroxydopamine

1995 • 82 citations

Cell-mediated delivery of brain-derived neurotrophic factor enhances dopamine levels in an MPP+ rat model of substantia nigra degeneration

1996 • 71 citations

Expression of Brain-Derived Neurotrophic Factor and TrkB Neurotrophin Receptors after Striatal Injury in the Mouse

1997 • 47 citations

Tyrosine kinase B messenger RNA expression in normal human brain and in the substantia nigra of parkinsonian patients: an in situ hybridization study

1998 • 46 citations

Expression of glial cell line-derived neurotrophic factor (GDNF) mRNA following mechanical injury to mouse striatum

1997 • 46 citations

Effects of brain-derived neurotrophic factor on neuronal structure of dopaminergic neurons in dissociated cultures of human fetal mesencephalon

1996 • 45 citations

Neuropathology in movement disorders.

1989 • 44 citations

Sham transplantation protects against 6-hydroxydopamine-induced dopaminergic toxicity in rats: behavioral and morphological evidence

1991 • 43 citations

Axonal regrowth upregulates ?-actin and Jun D mRNA expression

1996 • 33 citations

Potential of neurotrophic factors in therapy of Parkinson’s disease

1996 • 14 citations

Dopaminergic responses to striatal damage.

1996 • 14 citations

Surgical damage stimulates proliferation of dopamine uptake sites in normal mouse brain

1993 • 14 citations

Dopaminergic responses to striatal damage

1996 • 6 citations