Life span: getting the signal from the nervous system

Oxidants, oxidative stress and the biology of ageing

2000 • 8,990 citations

Oxidative Stress, Caloric Restriction, and Aging

1996 • 3,136 citations

A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function

2001 • 1,583 citations

Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

2001 • 1,398 citations

Genetic pathways that regulate ageing in model organisms

2000 • 1,341 citations

Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

2000 • 909 citations

Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons

1998 • 852 citations

Autonomous Control of Cell and Organ Size by CHICO, a Drosophila Homolog of Vertebrate IRS1–4

1999 • 838 citations

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

2001 • 814 citations

Thedaf‐2gene network for longevity regulates oxidative stress resistance and Mn‐superoxide dismutase gene expression inCaenorhabditis elegans

1999 • 721 citations

Aging and resistance to oxidative damage in Caenorhabditis elegans.

1993 • 720 citations

Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System

2000 • 661 citations

Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family

2001 • 637 citations

Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice¹

2000 • 613 citations

Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues

2000 • 608 citations

Regulation of lifespan by sensory perception in Caenorhabditis elegans

1999 • 554 citations

A Conserved Regulatory System for Aging

2001 • 526 citations

Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues

2000 • 483 citations

FLP Recombinase-Mediated Induction of Cu/Zn-Superoxide Dismutase Transgene Expression Can Extend the Life Span of Adult Drosophila melanogaster Flies

1999 • 462 citations

Dietary Restriction Increases the Number of Newly Generated Neural Cells, and Induces BDNF Expression, in the Dentate Gyrus of Rats

2000 • 396 citations

Cell Nonautonomy of C. elegans daf-2 Function in the Regulation of Diapause and Life Span

1998 • 362 citations

A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4

2001 • 342 citations

Slow aging during insect reproductive diapause: why butterflies, grasshoppers and flies are like worms

2001 • 326 citations

A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants

1999 • 244 citations

Inheritance of human longevity in Iceland

2000 • 234 citations

Dietary restriction and aging in rhesus monkeys: the University of Wisconsin study

2000 • 201 citations

Brain‐derived neurotrophic factor mediates an excitoprotective effect of dietary restriction in mice

2001 • 183 citations

Genes That Prolong Life: Relationships of Growth Hormone and Growth to Aging and Life Span

2001 • 182 citations

Dietary Restriction Stimulates BDNF Production in the Brain and Thereby Protects Neurons Against Excitotoxic Injury

2001 • 180 citations

Suppression of brain aging and neurodegenerative disorders by dietary restriction and environmental enrichment: molecular mechanisms

2001 • 174 citations

Catalase expression in delayed and premature aging mouse models☆

2000 • 172 citations

The effects of catalase gene overexpression on life span and resistance to oxidative stress in transgenic Drosophila melanogaster

1992 • 163 citations

Prolonged longevity of hypopituitary dwarf mice

2001 • 133 citations

Neurosecretory control of aging in Caenorhabditis elegans

1999 • 118 citations

Effects of growth hormone on hypothalamic catalase and Cu/Zn superoxide dismutase1

2000 • 109 citations

Transgenic methods for increasing Drosophila life span

2000 • 106 citations

Caloric restriction alters the feeding response of key metabolic enzyme genes

2001 • 105 citations