Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity

Chromatin Modifications and Their Function

2007 • 10,144 citations

High-Resolution Profiling of Histone Methylations in the Human Genome

2007 • 6,479 citations

Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1

2004 • 3,675 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

New DNA sequence rules for high affinity binding to histone octamer and sequence-directed nucleosome positioning

1998 • 1,703 citations

DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA

2007 • 1,465 citations

Genome-wide Map of Nucleosome Acetylation and Methylation in Yeast

2005 • 1,418 citations

Positional cloning of the APECED gene

1997 • 1,385 citations

How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers

2007 • 1,351 citations

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

1997 • 1,155 citations

Nuclear speckles: a model for nuclear organelles

2003 • 955 citations

Chromatin Compaction by a Polycomb Group Protein Complex

2004 • 815 citations

Aire regulates negative selection of organ-specific T cells

2003 • 789 citations

Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF

2006 • 777 citations

A CENTRAL ROLE FOR CENTRAL TOLERANCE

2006 • 730 citations

The evolutionary dynamics of eukaryotic gene order

2004 • 729 citations

Chromatin immunoprecipitation and microarray-based analysis of protein location

2006 • 723 citations

Central tolerance: learning self-control in the thymus

2005 • 641 citations

Insulators: exploiting transcriptional and epigenetic mechanisms

2006 • 630 citations

The Cellular Mechanism of Aire Control of T Cell Tolerance

2005 • 622 citations

Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

2005 • 540 citations

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

2002 • 463 citations

Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4.

1996 • 460 citations

RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination

2007 • 447 citations

Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression

2007 • 418 citations

Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire

2007 • 367 citations

Combined Action of PHD and Chromo Domains Directs the Rpd3S HDAC to Transcribed Chromatin

2007 • 317 citations

Proteomic Analysis of Interchromatin Granule Clusters

2004 • 289 citations

Proteome-wide Analysis in Saccharomyces cerevisiae Identifies Several PHD Fingers as Novel Direct and Selective Binding Modules of Histone H3 Methylated at Either Lysine 4 or Lysine 36

2006 • 252 citations

The autoimmune regulator PHD finger binds to non‐methylated histone H3K4 to activate gene expression

2008 • 226 citations

Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism

2008 • 191 citations

An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus

2007 • 181 citations

Distinct Contributions of Histone H3 Lysine 9 and 27 Methylation to Locus-Specific Stability of Polycomb Complexes

2004 • 176 citations

The Autoimmune Regulator (AIRE) Is a DNA-binding Protein

2001 • 172 citations

Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire

2008 • 164 citations

From artificial evolution to computational evolution: a research agenda

2006 • 152 citations

AIRE Recruits P-TEFb for Transcriptional Elongation of Target Genes in Medullary Thymic Epithelial Cells

2007 • 151 citations

HP1 Binding to Chromatin Methylated at H3K9 Is Enhanced by Auxiliary Factors

2006 • 130 citations

Chromosomal clustering of genes controlled by the aire transcription factor

2005 • 126 citations

AIRE and APECED: molecular insights into an autoimmune disease

2005 • 124 citations

Ectopic expression of peripheral-tissue antigens in the thymic epithelium: Probabilistic, monoallelic, misinitiated

2008 • 120 citations

The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression

2008 • 96 citations

AIRE's CARD Revealed, a New Structure for Central Tolerance Provokes Transcriptional Plasticity

2007 • 95 citations

NMR Structure of the First PHD Finger of Autoimmune Regulator Protein (AIRE1)

2005 • 89 citations

Establishment and characterization of cloned human thymic epithelial cell lines. Analysis of adhesion molecule expression and cytokine production

1994 • 86 citations

Subcellular Expression of Autoimmune Regulator Is Organized in a Spatiotemporal Manner

2004 • 71 citations

Autoantibodies against Aromatic l-Amino Acid Decarboxylase Identifies a Subgroup of Patients with Addison’s Disease1

2000 • 57 citations

The Autoimmune Regulator Directly Controls the Expression of Genes Critical for Thymic Epithelial Function

2007 • 54 citations

AIRE recruits multiple transcriptional components to specific genomic regions through tethering to nuclear matrix

2005 • 35 citations

Autoantibodies against Aromatic L-Amino Acid Decarboxylase Identifies a Subgroup of Patients with Addison's Disease

2000 • 29 citations