Blocking Cytochrome c Activity within Intact Neurons Inhibits Apoptosis

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1998 • 3,169 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Programmed Cell Death in Animal Development

1997 • 2,690 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Caspases: killer proteases

1997 • 2,440 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

Caspases: Intracellular Signaling by Proteolysis

1997 • 2,114 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1997 • 1,768 citations

Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

1998 • 1,651 citations

Double identity for proteins of the Bcl-2 family

1997 • 1,511 citations

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

1993 • 1,470 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

1998 • 1,226 citations

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2

1994 • 1,145 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

Conversion of Bcl-2 to a Bax-like Death Effector by Caspases

1997 • 1,116 citations

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

1993 • 1,044 citations

Inhibition of Bax Channel-Forming Activity by Bcl-2

1997 • 1,023 citations

Intracellular Signaling Pathways Activated by Neuropathic Factors

1996 • 958 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death

1995 • 800 citations

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

1996 • 731 citations

Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats.

1993 • 703 citations

Programmed cell death and Bcl-2 protection in very low oxygen

1995 • 638 citations

The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis

1997 • 625 citations

The role of DNA fragmentation in apoptosis

1995 • 608 citations

Channel formation by antiapoptotic protein Bcl-2

1997 • 604 citations

Ischemia-induced neuronal apoptosis

1996 • 600 citations

Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor.

1993 • 535 citations

Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.

1996 • 529 citations

Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution.

1995 • 524 citations

Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases

1996 • 519 citations

Modulation of cell death by Bcl-x _L through caspase interaction

1998 • 505 citations

Neural apoptosis

1995 • 464 citations

Histochemical detection of apoptosis in Parkinson's disease

1996 • 448 citations

Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria.

1996 • 411 citations

Role for Bcl-x_Las an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis

1997 • 397 citations

Bax Deletion Further Orders the Cell Death Pathway in Cerebellar Granule Cells and Suggests a Caspase-independent Pathway to Cell Death

1997 • 390 citations

A potential role for apoptosis in neurodegeneration and Alzheimer's disease

1995 • 382 citations

Signal transduction and gene regulation: the nuclear response to cAMP

1994 • 369 citations

DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis.

1996 • 351 citations

Cell-specific Induction of Apoptosis by Microinjection of Cytochrome c

1997 • 348 citations

Molecular Mechanisms of Developmental Neuronal Death

1993 • 330 citations

cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor.

1988 • 312 citations

The Ced-3/Interleukin 1β Converting Enzyme-like Homolog Mch6 and the Lamin-cleaving Enzyme Mch2α Are Substrates for the Apoptotic Mediator CPP32

1996 • 295 citations

Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione

1994 • 268 citations

Programmed Cell Death in the Developing Nervous System

1996 • 263 citations

Overexpression of Bcl-X(L) inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis.

1997 • 259 citations

Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis.

1996 • 247 citations

Activated Phosphatidylinositol 3-Kinase and Akt Kinase Promote Survival of Superior Cervical Neurons

1997 • 245 citations

The Bcl-2 family of proteins: regulators of cell death and survival

1994 • 238 citations

The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4

1998 • 237 citations

Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities.

1996 • 236 citations

Loss of Function of Cytochrome c in Jurkat Cells Undergoing Fas-mediated Apoptosis

1996 • 225 citations

Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases.

1996 • 223 citations

Enzymatic assay for deoxyribonucleoside triphosphates using synthetic oligonucleotides as template primers

1989 • 218 citations

The Death Programme in Cultured Sympathetic Neurones Can Be Suppressed at the Posttranslational Level by Nerve Growth Factor, Cyclic AMP, and Depolarization

1991 • 202 citations

Mutant Superoxide Dismutase-1-Linked Familial Amyotrophic Lateral Sclerosis: Molecular Mechanisms of Neuronal Death and Protection

1997 • 202 citations

Establishment of a Cell-Free System of Neuronal Apoptosis: Comparison of Premitochondrial, Mitochondrial, and Postmitochondrial Phases

1997 • 188 citations

Biochemical characterization of programmed cell death in NGF‐deprived sympathetic neurons

1992 • 146 citations

Interaction and Regulation of the Caenorhabditis elegans Death Protease CED-3 by CED-4 and CED-9

1997 • 130 citations

Apoptosis related antigen, LeY and nick-end labeling are positive in spinal motor neurons in amyotrophic lateral sclerosis

1994 • 129 citations

Importance of the redox state of cytochrome c during caspase activation in cytosolic extracts

1998 • 120 citations

The ins and outs of programmed cell death duringC. elegansdevelopment

1994 • 100 citations

Purification and Characterization of an Interleukin-1β-converting Enzyme Family Protease That Activates Cysteine Protease P32 (CPP32)

1996 • 87 citations

Determination of deoxyribonucleoside triphosphates using DNA polymerase: a critical evaluation

1981 • 82 citations

Involvement of caspases in sympathetic neuron apoptosis

1997 • 66 citations

Neuronal Death in Developmental Models: Possible Implications in Neuropathology

1996 • 50 citations

Molecular genetics of neuronal survival

1995 • 48 citations

Deoxynucleoside Induces Neuronal Apoptosis Independent of Neurotrophic Factors

1995 • 33 citations

A monoclonal antibody specific for a cytochrome c T cell stimulatory peptide inhibits T cell responses and affects the way the peptide associates with antigen‐presenting cells

1991 • 33 citations

Role of Ribonucleotide Reductase and Deoxynucleotide Pools in the Oxygen‐Dependent Control of DNA Replication in Ehrlich Ascites Cells

1997 • 29 citations

Maturation of the antibody response to the major epitope on the self antigen mouse cytochrome c. Restricted V gene usage, selected mutations, and increased affinity.

1996 • 22 citations

Morphological and Biochemical Changes in Neurons: Apoptosis versus Mitosis

1996 • 21 citations

Analysis of generalized two-dimensional homonuclear nmr spectra

1981 • 21 citations

Regulation of the salvage pathway of deoxynucleotides synthesis in apoptosis induced by growth factor deprivation

1996 • 19 citations

Expression of the Cyclic AMP‐dependent Protein Kinase (PKA) Catalytic Subunit from a Herpes Simplex Virus Vector Extends the Survival of Rat Sympathetic Neurons in the Absence of NGF

1994 • 10 citations