Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues

1969 • 6,007 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid

1989 • 1,769 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).

1979 • 1,680 citations

Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay

1987 • 1,280 citations

Selective Modification of Glutathione Metabolism

1983 • 1,272 citations

The Glutathione Status of Cells

1978 • 1,218 citations

Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress

1989 • 987 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

Dose‐dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli

1991 • 816 citations

Rapid Communication: Oxidative Stress Induces Apoptosis in Embryonic Cortical Neurons

1994 • 588 citations

Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake

1990 • 424 citations

Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons

1989 • 414 citations

Persistent inhibition of protein synthesis precedes delayed neuronal death in postischemic gerbil hippocampus

1986 • 380 citations

Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: Evidence for the role of cell death genes

1990 • 332 citations

1-Methyl-4-phenylpyridinium (MPP+) induces NADH-dependent superoxide formation and enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particles

1990 • 323 citations

Effect of N-acetylcysteine on the pulmonary response to endotoxin in the awake sheep and upon in vitro granulocyte function.

1984 • 310 citations

Heat shock-induced translational alterations in HeLa cells. Initiation factor modifications and the inhibition of translation.

1984 • 282 citations

Histochemical evaluation of glutathione in brain

1987 • 253 citations

Promotion of cystine uptake and its utilization for glutathione biosynthesis induced by cysteamine and N-acetylcysteine

1988 • 234 citations

Nerve growth factor withdrawal-induced cell death in neuronal PC12 cells resembles that in sympathetic neurons.

1992 • 221 citations

Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons

1991 • 215 citations

The use of monochlorobimane to determine hepatic GSH levels and synthesis

1990 • 214 citations

Effects of cycloheximide on delayed neuronal death in rat hippocampus

1990 • 202 citations

Autocrine production of extracellular catalase prevents apoptosis of the human CEM T-cell line in serum-free medium.

1993 • 187 citations

The role of glutathione in radiation and drug induced cytotoxicity.

1987 • 185 citations

Catalytic Oxidation of Glutathione and Other Sulfhydryl Compounds by Selenite

1958 • 171 citations

Secondary injury and acidosis.

1992 • 157 citations

A mechanism for glutamate toxicity in the C6 glioma cells involving inhibition of cystine uptake leading to glutathione depletion

1992 • 135 citations

Mechanism of action of paracetamol protective agents in mice in vivo

1984 • 127 citations

Glutathione Metabolism and Some Possible Functions of Glutathione in the Nervous System

1976 • 122 citations

Programmed cell death: its possible contribution to neurotoxicity mediated by calcium channel antagonists

1992 • 117 citations

A novel function of glutamine in cell culture: Utilization of glutamine for the uptake of cystine in human fibroblasts

1988 • 113 citations

Protein Synthesis in Brain Slices

1967 • 105 citations

Inhibition of protein synthesis prevents cell death in sensory and parasympathetic neurons deprived of neurotrophic factor in vitro

1990 • 103 citations

Glutamate toxicity in immature cortical neurons precedes development of glutamate receptor currents

1990 • 100 citations

Potassium-channel activation in response to low doses of gamma-irradiation involves reactive oxygen intermediates in nonexcitatory cells.

1993 • 88 citations

THE EFFECT OF EXTRACELLULAR POTASSIUM CONCENTRATION ON PROTEIN SYNTHESIS IN GUINEA‐PIG HIPPOCAMPAL SLICES^1,²

1977 • 76 citations

Glutamate Neurotoxicity and the Inhibition of Protein Synthesis in the Hippocampal Slice

1991 • 73 citations

Cycloheximide Reduces the Effects of Anoxic InsultIn VivoandIn Vitro

1992 • 67 citations

Adenovirus inhibition of cellular protein synthesis is prevented by the drug 2-aminopurine.

1990 • 58 citations

Role of glutathione in repair of free radical damage in hippocampus in vitro

1992 • 47 citations

On the metallothionein, glutathione and cysteine relationship in rat liver.

1990 • 46 citations

The effect of cycloheximide on natural and X-ray-induced cell death in the developing cerebral cortex

1992 • 40 citations

Serum growth factors cause rapid stimulation of protein synthesis and dephosphorylation of eIF-2 in serum deprived Ehrlich cells

1989 • 39 citations

Quantitative analysis of glutathione in rat central nervous system: comparison of GSH in infant brain with that in adult brain

1990 • 32 citations

Focal protein synthesis inhibition in a model of neonatal hypoxic-ischemic brain injury

1987 • 30 citations

Comparative study on the selenium- and N-acetylcysteine-related effects on the toxic action of hyperoxia, paraquat and the enzyme reaction hypoxanthine-xanthine oxidase in cultured endothelial cells

1987 • 28 citations

Protein Synthesis Under Dendritic Spine Synapses During Lesion-Induced Synaptogenesis: Evidence for Regulation of Reinnervation by the Target Cell

1986 • 11 citations

Glutathione in Prokaryotes

2017 • 1 citations

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