FTY720 Rescue Therapy in the Dark Agouti Rat Model of Experimental Autoimmune Encephalomyelitis: Expression of Central Nervous System Genes and Reversal of Blood‐Brain‐Barrier Damage

Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study

2007 • 1,681 citations

Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

2002 • 1,655 citations

The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors

2002 • 1,478 citations

Inflammation in Neurodegenerative Disease—A Double-Edged Sword

2002 • 1,167 citations

Oral Fingolimod (FTY720) for Relapsing Multiple Sclerosis

2006 • 1,043 citations

TH1 cells control themselves by producing interleukin-10

2007 • 599 citations

Autoimmunity to Myelin Oligodendrocyte Glycoprotein in Rats Mimics the Spectrum of Multiple Sclerosis Pathology

1998 • 524 citations

Neurotrophins are required for nerve growth during development

2001 • 519 citations

Monocyte/macrophage differentiation in early multiple sclerosis lesions

1995 • 513 citations

A quantitative analysis of oligodendrocytes in multiple sclerosis lesions

1999 • 445 citations

Multiple roles for MMPs and TIMPs in cerebral ischemia

2005 • 406 citations

CD1 antigen presentation: how it works

2007 • 333 citations

Widespread Demyelination in the Cerebellar Cortex in Multiple Sclerosis

2007 • 316 citations

Brain Penetration of the Oral Immunomodulatory Drug FTY720 and Its Phosphorylation in the Central Nervous System during Experimental Autoimmune Encephalomyelitis: Consequences for Mode of Action in Multiple Sclerosis

2007 • 316 citations

A High-Density Screen for Linkage in Multiple Sclerosis

2005 • 296 citations

TGFβ signalling in control of T-cell-mediated self-reactivity

2007 • 294 citations

Amelioration of Experimental Autoimmune Encephalomyelitis in Lewis Rats by FTY720 Treatment

2003 • 281 citations

Self glycolipids as T-cell autoantigens

1999 • 272 citations

MHC haplotype-dependent regulation of MOG-induced EAE in rats.

1998 • 257 citations

FTY720 modulates human oligodendrocyte progenitor process extension and survival

2007 • 251 citations

IL-18: a key player in neuroinflammation and neurodegeneration?

2005 • 223 citations

Sphingosine 1-phosphate receptor agonists attenuate relapsing–remitting experimental autoimmune encephalitis in SJL mice

2004 • 221 citations

FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration.

2005 • 219 citations

Functional Genomic Analysis of Remyelination Reveals Importance of Inflammation in Oligodendrocyte Regeneration

2003 • 183 citations

Interaction of the N-Terminal Domain of the AMPA Receptor GluR4 Subunit with the Neuronal Pentraxin NP1 Mediates GluR4 Synaptic Recruitment

2007 • 181 citations

β-Dystroglycan as a Target for MMP-9, in Response to Enhanced Neuronal Activity

2007 • 179 citations

The Immunomodulator FTY720 Has a Direct Cytoprotective Effect in Oligodendrocyte Progenitors

2007 • 173 citations

FTY720 Ameliorates Th1-Mediated Colitis in Mice by Directly Affecting the Functional Activity of CD4+CD25+ Regulatory T Cells

2007 • 158 citations

FTY720 sustains and restores neuronal function in the DA rat model of MOG-induced experimental autoimmune encephalomyelitis

2007 • 157 citations

Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells

2007 • 156 citations

Protracted, relapsing and demyelinating experimental autoimmune encephalomyelitis in DA rats immunized with syngeneic spinal cord and incomplete Freund's adjuvant

1995 • 142 citations

The Immune Modulator FTY720 Inhibits Sphingosine-1-phosphate Lyase Activity

2005 • 137 citations

A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting

2003 • 133 citations

Characterization of lysophosphatidic acid and sphingosine‐1‐phosphate‐mediated signal transduction in rat cortical oligodendrocytes

2003 • 121 citations

Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses

2006 • 114 citations

Edg-8 receptors are preferentially expressed in oligodendrocyte lineage cells of the rat CNS

2003 • 98 citations

[28] Sphingosine-1-phosphate lyase

2000 • 97 citations

FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis

2007 • 93 citations

IL-18 Induces Monocyte Chemotactic Protein-1 Production in Macrophages through the Phosphatidylinositol 3-Kinase/Akt and MEK/ERK1/2 Pathways

2005 • 92 citations

Effects of LPA and S1P on the Nervous System and Implications for Their Involvement in Disease

2006 • 88 citations

Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) in patients with relapsing–remitting multiple sclerosis treated with interferon beta

2005 • 75 citations

Genomics in multiple sclerosis—Current state and future directions

2007 • 74 citations

Secreted phospholipase A2 activity in experimental autoimmune encephalomyelitis and multiple sclerosis.

2006 • 49 citations

Differential Expression of Sonic Hedgehog Immunoreactivity During Lesion Evolution in Autoimmune Encephalomyelitis

2005 • 46 citations

CD1 expression is differentially regulated by microglia, macrophages and T cells in the central nervous system upon inflammation and demyelination

2001 • 34 citations

Gene and Protein Expression Profiling of the Microvascular Compartment in Experimental Autoimmune Encephalomyelitis in C57BI/6 and SJL Mice

2006 • 34 citations

RECOVERY FROM ACUTE EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN THE LEWIS RAT

1989 • 32 citations

IVIG enters the central nervous system during treatment of experimental autoimmune encephalomyelitis and is localised to inflammatory lesions

2006 • 19 citations

Isothiocyanate Inhibits Restitution and Wound Repair after Injury in the Stomach: Ex Vivo and in Vitro Studies

2007 • 13 citations