Protracted, relapsing and demyelinating experimental autoimmune encephalomyelitis in DA rats immunized with syngeneic spinal cord and incomplete Freund's adjuvant

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

1992 • 1,200 citations

Large Scale Preparation of Myelin Basic Protein from Central Nervous Tissue of Several Mammalian Species

1972 • 949 citations

The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis

1981 • 917 citations

Analysis of cell surfaces by xenogeneic myeloma-hybrid antibodies: Differentiation antigens of rat lymphocytes

1977 • 777 citations

Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein.

1988 • 721 citations

Identification of Ia glycoproteins in rat thymus and purification from rat spleen

1979 • 682 citations

Two subsets of rat T lymphocytes defined with monoclonal antibodies

1980 • 678 citations

Reverse ELISPOT assay for clonal analysis of cytokine production I. Enumeration of gamma-interferon-secreting cells

1988 • 496 citations

Synthesis and incorporation of myelin polypeptides into CNS myelin.

1982 • 422 citations

Mouse monoclonal antibodies against rat major histocompatibility antigens. Two Ia antigens and expression of Ia and class I antigens in rat thymus

1982 • 364 citations

Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma.

1990 • 363 citations

Experimental Allergic Encephalomyelitis. A Useful Model for Multiple Sclerosis

1984 • 340 citations

MRC OX‐19: A monoclonal antibody that labels rat T lymphocytes and augments in vitro proliferative responses

1984 • 305 citations

Molecular and antigenic heterogeneity of the rat leukocyte‐common antigen from thymocytes and T and B lymphocytes

1985 • 286 citations

The demyelinating potential of antibodies to myelin oligodendrocyte glycoprotein is related to their ability to fix complement

1991 • 284 citations

T cells specific for the myelin oligodendrocyte glycoprotein mediate an unusual autoimmune inflammatory response in the central nervous system

1993 • 265 citations

In situ hybridization with digoxigenin-labeled probes: sensitive and reliable detection method applied to myelinating rat brain

1992 • 240 citations

The distribution of Ia antigen in the lesions of rat acute experimental allergic encephalomyelitis

1986 • 214 citations

The Purification and Characterization of Rat Gamma Interferon by Use of Two Monoclonal Antibodies

1986 • 204 citations

Soluble recombinant complement receptor 1 inhibits inflammation and demyelination in antibody-mediated demyelinating experimental allergic encephalomyelitis.

1994 • 201 citations

Experimental allergic encephalomyelitis in the absence of a classical delayed-type hypersensitivity reaction. Severe paralytic disease correlates with the presence of interleukin 2 receptor-positive cells infiltrating the central nervous system.

1987 • 182 citations

Induction of stress protein HSP70 in nerve cells after status epilepticus in the rat

1989 • 179 citations

Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: dynamics of mRNA expression for interleukin-10, interleukin-12, cytolysin, tumor necrosis factor α and tumor necrosis factor β

1995 • 179 citations

Involvement of distinct murine T-cell receptors in the autoimmune encephalitogenic response to nested epitopes of myelin basic protein.

1988 • 172 citations

Demyelination Induced in Aggregating Brain Cell Cultures by a Monoclonal Antibody Against Myelin/Oligodendrocyte Glycoprotein

1990 • 165 citations

Chronologic neuropathology of relapsing experimental allergic encephalomyelitis in the mouse.

1982 • 164 citations

Interferon γ, interleukin 4 and transforming growth factor β in experimental autoimmune encephalomyelitis in lewis rats: Dynamics of cellular mrna expression in the central nervous system and lymphoid cells

1995 • 159 citations

Genetic Control of Susceptibility to Experimental Allergic Encephalomyelitis in Rats

1973 • 152 citations

Induction of persistently demyelinated lesions in the rat following the repeated adoptive transfer of encephalitogenic T cells and demyelinating antibody

1992 • 146 citations

Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement

1991 • 144 citations

The demyelinating potential of antibodies to myelin oligodendrocyte glycoprotein is related to their ability to fix complement

1991 • 136 citations

Homologous type ii collagen—induced arthritis in rats

1990 • 135 citations

Detection of intracellular expression and secretion of interferon‐γ at the single‐cell level after activation of human T cells with tetanus toxoid in vitro

1990 • 130 citations

Specificity of T lymphocyte lines for peptides of myelin basic protein.

1985 • 125 citations

CHRONIC DISSEMINATED ALLERGIC ENCEPHALOMYELITIS IN GUINEA PIGS*

1965 • 124 citations

T cell immunity and interferon-γ secretion during experimental allergic encephalomyelitis in Lewis rats

1991 • 107 citations

Inflammation in the nervous system. Basic mechanisms and immunological concepts.

1991 • 100 citations

T cell determinants of myelin basic protein include a unique encephalitogenic I-E-restricted epitope for Lewis rats.

1989 • 98 citations

Low-dose cyclosporin A induces relapsing remitting experimental allergic encephalomyelitis in the Lewis rat

1988 • 95 citations

Genetic Control of Susceptibility to Experimental Allergic Encephalomyelitis and the Ag-B Locus of Rats

1975 • 89 citations

Synergy between encephalitogenic T cells and myelin basic protein-specific antibodies in the induction of experimental autoimmune encephalomyelitis

1992 • 86 citations

A rapid and efficient immunization protocol for production of monoclonal antibodies reactive with autoantigens

1985 • 86 citations

Autoimmune T cells: Immune recognition of normal and variant peptide epitopes and peptide-based therapy

1989 • 81 citations

Chronic relapsing experimental allergic encephalomyelitis in the Lewis rat

1985 • 78 citations

Chronic experimental allergic encephalomyelitis in guinea pigs induced by proteolipid protein

1985 • 75 citations

The major histocompatibility complex influences myelin basic protein 63‐88‐induced T cell cytokine profile and experimental autoimmune encephalomyelitis

1993 • 71 citations

Genetic control of the development of experimental allergic encephalomyelitis in rats. Separation of MHC and non-MHC gene effects.

1988 • 70 citations

Allergic encephalomyelitis. Isolation of an encephalitogenic peptide active in the monkey.

1975 • 69 citations

Interferon‐γ potentiates antibody‐mediated demyelination in vivo

1992 • 65 citations

Immunology of multiple sclerosis.

1992 • 64 citations

Direct binding of autoimmune disease related T cell epitopes to purified Lewis rat MHC class II molecules

1994 • 61 citations

Immunogenetics of Collagen-Induced Arthritis in Rats

1988 • 58 citations

Induction of recurrent experimental allergic encephalomyelitis with myelin basic protein

1981 • 52 citations

Relapsing experimental allergic encephalomyelitis an autoimmune model of multiple sclerosis

1985 • 40 citations

Differing responses of inbred rat strains in experimental autoimmune thyroiditis

1975 • 38 citations

Resistance to the induction of EAE in AO rats: its prevention by the pre-treatment with cyclophosphamide or low dose of irradiation.

1982 • 35 citations

Antibodies against I-A and I-E determinants inhibit the activation and function of encephalitogenic T-lymphocyte lines

1986 • 34 citations

Experimental autoimmune encephalomyelitis in “low” and “high” interleukin 2 producer rats

1989 • 32 citations

Experimental Autoimmune Demyelination: Chronic Relapsing Models and Their Therapeutic Implications for Multiple Sclerosis^a

1984 • 30 citations

Encephalitogenic and proliferative responses of Lewis rat lymphocytes distinguished by position 75- and 80-substituted peptides of myelin basic protein.

1989 • 30 citations

Myelin basic protein speciation.

1984 • 29 citations

Analysis of T cell subsets after induction of experimental autoimmune encephalomyelitis in susceptible and resistant strains of rats

1990 • 26 citations

Analysis of the T cell repertoire for myelin basic protein in thymus‐grafted and other types of chimera: evidence that major histocompatibility complex molecules on accessory cells rather than T cell specificity mainly regulate susceptibility to autoimmune encephalomyelitis

1990 • 24 citations

The immune response to myelin proteolipid protein in the Lewis rat: identification of the immunodominant B cell epitope

1990 • 22 citations

Specific and Long‐Lasting Protection from Collagen‐Induced Arthritis and Oil‐Induced Arthritis in DA Rats by Administration of Immunogens

1995 • 21 citations

The Application of the Irradiated Hamster Test to the Study of Experimental Allergic Encephalomyelitis

1968 • 20 citations

Susceptibility to oil-induced arthritis in the DA rat is determined by MHC and non-MHC genes.

1995 • 19 citations

Sulfasalizine aggravates experimental autoimmune encephalomyelitis and causes an increase in the number of autoreactive T cells

1991 • 16 citations

A relapsing form of allergic encephalomyelitis in rats due to enhanced absorption of inoculum.

1986 • 12 citations

Therapeutic effects of 15-deoxyspergualin in acute and chronic relapsing experimental allergic encephalomyelitis (EAE) as models for multiple sclerosis (MS).

1991 • 10 citations

A Relapsing Form of Allergic Encephalomyelitis in Rats Due to Enhanced Absorption of Inoculum

1986 • 10 citations

Effects of FK 506 on acute experimental allergic encephalomyelitis.

1991 • 9 citations