ZAP-70 Protein Tyrosine Kinase Is Constitutively Targeted to the T Cell Cortex Independently of its SH2 Domains

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

Active and Inactive Protein Kinases: Structural Basis for Regulation

1996 • 1,361 citations

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1992 • 1,046 citations

ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

1992 • 1,037 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

Localization of Protein Kinases by Anchoring Proteins: a Theme in Signal Transduction

1995 • 911 citations

The T Cell Receptor/CD3 Complex: A Dynamic Protein Ensemble

1988 • 786 citations

A one-step purification of membrane proteins using a high efficiency immunomatrix.

1982 • 782 citations

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1995 • 726 citations

Sequential Interactions of the TCR with Two Distinct Cytoplasmic Tyrosine Kinases

1994 • 711 citations

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1992 • 574 citations

Essential role for ZAP-70 in both positive and negative selection of thymocytes

1995 • 554 citations

T cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases

1993 • 552 citations

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1992 • 514 citations

Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex.

1993 • 510 citations

Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis

1991 • 449 citations

T cell antigen receptor activation pathways: The tyrosine kinase connection

1991 • 442 citations

Identification and characterization of a novel cytoskeleton-associated pp60src substrate.

1991 • 435 citations

ERM (ezrin/radixin/moesin) family: from cytoskeleton to signal transduction

1997 • 363 citations

Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function.

1995 • 355 citations

Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes.

1996 • 324 citations

Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase.

1996 • 308 citations

αβ T Cell Development Is Abolished in Mice Lacking Both Lck and Fyn Protein Tyrosine Kinases

1996 • 294 citations

Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor zeta and CD3 epsilon from activated Jurkat T cells.

1993 • 271 citations

Syk Protein-tyrosine Kinase Is Regulated by Tyrosine-phosphorylated Iga/Ig/3 Immunoreceptor Tyrosine Activation Motif Binding and Autophosphorylation

1995 • 270 citations

Molecular Glue: Kinase Anchoring and Scaffold Proteins

1996 • 264 citations

T Cell Activation Induces Rapid Tyrosine Phosphorylation of a Limited Number of Cellular Substrates

1989 • 258 citations

ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells

1994 • 254 citations

Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling.

1994 • 248 citations

More on target with protein phosphorylation: conferring specificity by location.

1996 • 225 citations

Identification by electrospray ionization mass spectrometry of the sites of tyrosine phosphorylation induced in activated Jurkat T cells on the protein tyrosine kinase ZAP-70.

1994 • 215 citations

Fyn Can Partially Substitute for Lck in T Lymphocyte Development

1996 • 213 citations

Syk Is Activated by Phosphotyrosine-containing Peptides Representing the Tyrosine-based Activation Motifs of the High Affinity Receptor for IgE

1995 • 207 citations

ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity.

1995 • 196 citations

Activating and Inhibitory Mutations in Adjacent Tyrosines in the Kinase Domain of ZAP-70

1995 • 183 citations

Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytes.

1994 • 180 citations

Regulation of antigen receptor signal transduction by protein tyrosine kinases

1996 • 179 citations

Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif

1994 • 179 citations

Effects of p56lck deficiency on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T-cell line.

1992 • 175 citations

The T cell antigen receptor zeta chain is tyrosine phosphorylated upon activation.

1988 • 167 citations

p56lck interacts via its src homology 2 domain with the ZAP-70 kinase.

1994 • 159 citations

Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules.

1993 • 156 citations

Binding of ZAP-70 to Phosphorylated T-Cell Receptor ζ and η Enhances Its Autophosphorylation and Generates Specific Binding Sites for SH2 Domain-Containing Proteins

1995 • 154 citations

Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance.

1995 • 151 citations

Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex.

1994 • 148 citations

The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav.

1994 • 140 citations

Distinct Tyrosine Phosphorylation Sites in ZAP-70 Mediate Activation and Negative Regulation of Antigen Receptor Function

1996 • 139 citations

Retargeting of cytosolic proteins to the plasma membrane by the Lck protein tyrosine kinase dual acylation motif

1997 • 136 citations

The CD3 chains of the T cell antigen receptor associate with the ZAP-70 tyrosine kinase and are tyrosine phosphorylated after receptor stimulation.

1993 • 134 citations

Membrane interactions with the actin cytoskeleton

1994 • 134 citations

The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling.

1996 • 132 citations

Syk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/zeta complex.

1995 • 130 citations

Interaction cloning of protein kinase C substrates.

1993 • 122 citations

Identification and Characterization of a Novel Cytoskeleton-Associated pp60^src Substrate

1991 • 113 citations

Reconstitution of Syk function by the ZAP-70 protein tyrosine kinase

1995 • 101 citations

Multiple components of the T cell antigen receptor complex become tyrosine-phosphorylated upon activation.

1993 • 99 citations

The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-zeta subunit.

1995 • 98 citations

More on target with protein phosphorylation: conferring specificity by location

1996 • 93 citations

Enhancement of Lymphocyte Responsiveness by a Gain-of-Function Mutation of ZAP-70

1996 • 91 citations

TCR Activation of ZAP70 Is Impaired in CD4+CD8+ Thymocytes as a Consequence of Intrathymic Interactions that Diminish Available p56lck

1996 • 83 citations

Protein Kinase C Domains Involved in Interactions with Other Proteins

1994 • 82 citations

Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase.

1996 • 76 citations

Mutation of Tyrosines 492/493 in the Kinase Domain of ZAP-70 Affects Multiple T-cell Receptor Signaling Pathways

1996 • 72 citations

Interactions between the Protein-tyrosine Kinase ZAP-70, the Proto-oncoprotein Vav, and Tubulin in Jurkat T Cells

1995 • 71 citations

MOLECULAR AND GENETIC INSIGHTS INTO T CELL ANTIGEN RECEPTOR STRUCTURE AND FUNCTION

1991 • 65 citations

Tyrosine phosphorylation of α tubulin in human T lymphocytes

1994 • 54 citations

Lymphocyte antigen receptor activation of a focal adhesion kinase-related tyrosine kinase substrate.

1994 • 47 citations

Effects of p56^lck Deficiency on the Growth and Cytolytic Effector Function of an Interleukin-2-Dependent Cytotoxic T-Cell Line

1992 • 44 citations

The Kinase, SH3, and SH2 Domains of Lck Play Critical Roles in T-Cell Activation after ZAP-70 Membrane Localization

1996 • 42 citations

Regulation of Zap-70 by Src Family Tyrosine Protein Kinases in an Antigen-specific T-cell Line

1995 • 39 citations

Syk Mutation in Jurkat E6-derived Clones Results in Lack of p72syk Expression

1995 • 35 citations

The T cell receptor associated CD3‐ϵ protein is phosphorylated upon T cell activation in the two tyrosine residues of a conserved signal transduction motif

1993 • 35 citations

Correlation between protein kinase C binding proteins and substrates in REF52 cells.

1994 • 34 citations

Immunodeficiency Diseases: Multiple roles for ZAP-70

1994 • 33 citations

Identification of a gene encoding a novel protein-tyrosine kinase containing SH2 domains and ankyrin-like repeats.

1994 • 33 citations

Intracellular localization of tyrosine kinase substrates beneath crosslinked surface immunoglobulins in B cells.

1991 • 26 citations