TCR Activation of ZAP70 Is Impaired in CD4+CD8+ Thymocytes as a Consequence of Intrathymic Interactions that Diminish Available p56lck

Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*

1979 • 1,989 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen‐Reactivity

1983 • 1,040 citations

ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

1992 • 1,037 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

Mice lacking MHC class II molecules

1991 • 869 citations

GPI-Anchored Cell-Surface Molecules Complexed to Protein Tyrosine Kinases

1991 • 848 citations

Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.

1989 • 778 citations

Sequential Interactions of the TCR with Two Distinct Cytoplasmic Tyrosine Kinases

1994 • 711 citations

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

1991 • 695 citations

Depletion of CD4 ⁺ T Cells in Major Histocompatibility Complex Class II-Deficient Mice

1991 • 673 citations

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

1989 • 671 citations

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

1990 • 647 citations

Partial T cell signaling: Altered phospho-? and lack of zap70 recruitment in APL-induced T cell anergy

1994 • 608 citations

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1992 • 574 citations

Essential role for ZAP-70 in both positive and negative selection of thymocytes

1995 • 554 citations

Defective T cell receptor signaling and CD8+ thymic selection in humans lacking Zap-70 kinase

1994 • 552 citations

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA

1985 • 550 citations

The Role of Protein Tyrosine Kinases and Protein Tyrosine Phosphatases in T Cell Antigen Receptor Signal Transduction

1994 • 519 citations

Human Severe Combined Immunodeficiency Due to a Defect in ZAP-70, a T Cell Tyrosine Kinase

1994 • 516 citations

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1992 • 514 citations

ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists

1995 • 510 citations

Selective Events in T Cell Development

1994 • 486 citations

The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein.

1991 • 415 citations

T cell activation by clustered tyrosine kinases

1993 • 379 citations

The Ick tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

1989 • 362 citations

Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function.

1995 • 355 citations

Identification of the components of the murine T cell antigen receptor complex

1985 • 333 citations

Another view of the selective model of thymocyte selection

1993 • 280 citations

ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells

1994 • 254 citations

Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes

1987 • 248 citations

Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes

1993 • 228 citations

Identification by electrospray ionization mass spectrometry of the sites of tyrosine phosphorylation induced in activated Jurkat T cells on the protein tyrosine kinase ZAP-70.

1994 • 215 citations

Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage

1991 • 209 citations

Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: A new perspective on thymic commitment and selection

1995 • 207 citations

Activating and Inhibitory Mutations in Adjacent Tyrosines in the Kinase Domain of ZAP-70

1995 • 183 citations

Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation.

1992 • 173 citations

Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site.

1990 • 158 citations

Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules.

1993 • 156 citations

Binding of ZAP-70 to Phosphorylated T-Cell Receptor ζ and η Enhances Its Autophosphorylation and Generates Specific Binding Sites for SH2 Domain-Containing Proteins

1995 • 154 citations

Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways.

1989 • 151 citations

Development of the CD4 and CD8 lineage of T cells: instruction versus selection.

1991 • 144 citations

Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain

1989 • 140 citations

Inhibition of T Cell Receptor Expression and Function in Immature CD4 ⁺ cD8 ⁺ Cells by CD4

1990 • 129 citations

Distribution of H-2 microenvironments in the mouse thymus. Immunoelectron microscopic identification of I-A and H-2K bearing cells.

1980 • 127 citations

The molecular chaperone calnexin is expressed on the surface of immature thymocytes in association with clonotype-independent CD3 complexes.

1995 • 115 citations

Temporal regulation of non-transmembrane protein tyrosine kinase enzyme activity following T cell antigen receptor engagement.

1994 • 109 citations

Both immature and mature T cells mobilize Ca2+ in response to antigen receptor crosslinking

1987 • 89 citations

F2 (Pmp)2 -TAM ζ3 , a Novel Competitive Inhibitor of the Binding of ZAP-70 to the T Cell Antigen Receptor, Blocks Early T Cell Signaling

1995 • 88 citations

Engagement of the CD4 molecule influences cell surface expression of the T-cell receptor on thymocytes

1988 • 84 citations

Expression and Interactions of the Src Family of Tyrosine Protein Kinases in T Lymphocytes

1991 • 83 citations

Developmentally regulated expression of CD3 components independent of clonotypic T cell antigen receptor complexes on immature thymocytes.

1994 • 64 citations

Regulation of Zap-70 by Src Family Tyrosine Protein Kinases in an Antigen-specific T-cell Line

1995 • 39 citations

Identification of a murine monoclonal antibody specific for an allotypic determinant on mouse CD3

1991 • 35 citations

Subcellular localization of T-cell receptor complexes containing tyrosine-phosphorylated zeta proteins in immature CD4+CD8+ thymocytes.

1993 • 19 citations