Syk Mutation in Jurkat E6-derived Clones Results in Lack of p72syk Expression

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

Isolation and Characterization of Full-Length cDNA Clones for Human α-, β-, and γ-Actin mRNAs: Skeletal but Not Cytoplasmic Actins Have an Amino-Terminal Cysteine that Is Subsequently Removed

1983 • 1,220 citations

ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

1992 • 1,037 citations

Sequential Interactions of the TCR with Two Distinct Cytoplasmic Tyrosine Kinases

1994 • 711 citations

Defective T cell receptor signaling and CD8+ thymic selection in humans lacking Zap-70 kinase

1994 • 552 citations

Isolation and characterization of full-length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed.

1983 • 546 citations

Human Severe Combined Immunodeficiency Due to a Defect in ZAP-70, a T Cell Tyrosine Kinase

1994 • 516 citations

ZAP-70 Deficiency in an Autosomal Recessive form of Severe Combined Immunodeficiency

1994 • 495 citations

Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium.

1984 • 452 citations

Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis

1991 • 449 citations

The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein.

1991 • 415 citations

Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production.

1991 • 349 citations

Sequence requirements for induction of cytolysis by the T cell antigenFc receptor ζ chain

1992 • 333 citations

Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain.

1993 • 318 citations

Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor.

1992 • 298 citations

Syk Protein-tyrosine Kinase Is Regulated by Tyrosine-phosphorylated Iga/Ig/3 Immunoreceptor Tyrosine Activation Motif Binding and Autophosphorylation

1995 • 270 citations

Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling.

1994 • 248 citations

Protein-tyrosine kinase p72syk in high affinity IgE receptor signaling. Identification as a component of pp72 and association with the receptor gamma chain after receptor aggregation.

1993 • 232 citations

Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin alpha IIb beta 3.

1994 • 227 citations

Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases.

1994 • 219 citations

Syk Is Activated by Phosphotyrosine-containing Peptides Representing the Tyrosine-based Activation Motifs of the High Affinity Receptor for IgE

1995 • 207 citations

Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex.

1994 • 148 citations

Isolation and characterization of a T-lymphocyte somatic mutant with altered signal transduction by the antigen receptor.

1987 • 141 citations

Phosphorylation of human erythrocyte band 3 by endogenous p72syk.

1994 • 138 citations

Stimulation of macrophage Fc gamma RIIIA activates the receptor-associated protein tyrosine kinase Syk and induces phosphorylation of multiple proteins including p95Vav and p62/GAP-associated protein.

1994 • 117 citations

p56lck-independent activation and tyrosine phosphorylation of p72syk by T-cell antigen receptor/CD3 stimulation.

1994 • 114 citations

Temporal regulation of non-transmembrane protein tyrosine kinase enzyme activity following T cell antigen receptor engagement.

1994 • 109 citations

T cell antigen receptor signaling: Three families of tyrosine kinases and a phosphatase

1994 • 92 citations

Molecular Cloning of Rodent p72Syk.

1995 • 40 citations

In vitro amplification of DNA fragments > 10 kb

1992 • 34 citations