MOLECULAR AND GENETIC INSIGHTS INTO T CELL ANTIGEN RECEPTOR STRUCTURE AND FUNCTION

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

Studies of Inositol Phospholipid-Specific Phospholipase C

1989 • 914 citations

Interaction between CD4 and class II MHC molecules mediates cell adhesion

1987 • 823 citations

The T Cell Receptor/CD3 Complex: A Dynamic Protein Ensemble

1988 • 786 citations

Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester

1985 • 753 citations

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

1989 • 671 citations

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

1990 • 647 citations

Developmental Biology of T Cells in T Cell-Receptor Transgenic Mice

1990 • 637 citations

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1990 • 629 citations

Transfer of specificity by murine α and β T-cell receptor genes

1986 • 568 citations

The T Cell Receptor

1987 • 554 citations

Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation

1989 • 509 citations

Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line.

1984 • 504 citations

The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.

1989 • 447 citations

Cell-cell adhesion mediated by CD8 and MHC class I molecules

1988 • 445 citations

Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation.

1990 • 432 citations

Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase.

1989 • 425 citations

Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides

1991 • 391 citations

Identification of the components of the murine T cell antigen receptor complex

1985 • 333 citations

Antiphosphotyrosine Recovery of Phospholipase C Activity After EGF Treatment of A-431 Cells

1988 • 324 citations

Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer

1985 • 299 citations

The Structure of the CD4 and CD8 Genes

1987 • 276 citations

Molecular Cloning of the Zeta Chain of the T Cell Antigen Receptor

1988 • 275 citations

Genetic and Mutational Analysis of the T-Cell Antigen Receptor

1990 • 275 citations

Differential activation requirements for virgin and memory T cells.

1988 • 271 citations

Structure, Function, and Serology of the T-Cell Antigen Receptor Complex

1987 • 264 citations

Specific antigen—la activation of transfected human T cells expressing murine Ti αβ —human T3 receptor complexes

1987 • 247 citations

Building a multichain receptor: synthesis, degradation, and assembly of the T-cell antigen receptor.

1987 • 232 citations

CD45 regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T or B cells.

1988 • 223 citations

CD3-negative natural killer cells express ε TCR as part of a novel molecular complex

1989 • 210 citations

Cholera toxin inhibits the T-cell antigen receptor-mediated increases in inositol trisphosphate and cytoplasmic free calcium.

1986 • 202 citations

Inhibition of PDGF β Receptor Signal Transduction by Coexpression of a Truncated Receptor

1991 • 173 citations

Expression of T3 in association with a molecule distinct from the T-cell antigen receptor heterodimer.

1986 • 168 citations

T cell antigen receptor engagement stimulates c-raf phosphorylation and induces c-raf-associated kinase activity via a protein kinase C-dependent pathway.

1990 • 147 citations

Assembly of the human T cell receptor-CD3 complex takes place in the endoplasmic reticulum and involves intermediary complexes between the CD3-gamma.delta.epsilon core and single T cell receptor alpha or beta chains.

1988 • 142 citations

Isolation and characterization of a T-lymphocyte somatic mutant with altered signal transduction by the antigen receptor.

1987 • 141 citations

Comparison of T3-associated 49- and 43-kilodalton cell surface molecules on individual human T-cell clones: evidence for peptide variability in T-cell receptor structures.

1983 • 133 citations

Stimulation of the phosphatidyl-inositol pathway can induce T-cell activation

1990 • 129 citations

Role of the zeta chain in the expression of the T cell antigen receptor: genetic reconstitution studies.

1989 • 128 citations

Enzymatically inactive p60c-src mutant with altered ATP-binding site is fully phosphorylated in its carboxy-terminal regulatory region

1987 • 117 citations

T Cell CD3-ζη Heterodimer Expression and Coupling to Phosphoinositide Hydrolysis

1988 • 113 citations

The human T cell receptor genes are targets for chromosomal abnormalities in T cell tumors

1989 • 109 citations

Familial Defect in the Surface Expression of the T-Cell Receptor–CD3 Complex

1988 • 103 citations

A protein kinase C cDNA without the regulatory domain is active after transfection in vivo in the absence of phorbol ester.

1989 • 102 citations

Dissociation of phosphoinositide hydrolysis and Ca2+ fluxes from the biological responses of a T-cell hybridoma

1988 • 102 citations

The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes.

1991 • 98 citations

Activation-Driven Programmed Cell Death and T Cell Receptor ζη Expression

1989 • 98 citations

Pleiotropic loss of activation pathways in a T-cell receptor α-chain deletion variant of a cytolytic T-cell clone

1987 • 89 citations

Membrane Anchoring of a Human IgG Fc Receptor (CD16) Determined by a Single Amino Acid

1989 • 88 citations

CD45-protein tyrosine phosphatase cross-linking inhibits T cell receptor CD3-mediated activation in human T cells.

1989 • 85 citations

Assembly and function of the T cell antigen receptor. Requirement of either the lysine or arginine residues in the transmembrane region of the alpha chain.

1990 • 84 citations

Subunit interactions within the T-cell antigen receptor: clues from the study of partial complexes.

1988 • 84 citations

Structure and function of the T cell antigen receptor.

1990 • 75 citations

A second signal for T cell mitogenesis provided by monoclonal antibodies CD45 (T200)

1987 • 64 citations

Function of a Heterologous Muscarinic Receptor in T Cell Antigen Receptor Signal Transduction Mutants

1989 • 58 citations

Transfection of genes encoding the T cell receptor-associated CD3 complex into COS cells results in assembly of the macromolecular structure.

1988 • 53 citations

Association and dissociation of the murine T cell receptor associated protein (TRAP). Early events in the biosynthesis of a multisubunit receptor.

1988 • 49 citations

Assembly, intracellular processing, and expression at the cell surface of the human alpha beta T cell receptor/CD3 complex. Function of the CD3-zeta chain.

1989 • 47 citations

Surface expression of only gamma delta and/or alpha beta T cell receptor heterodimers by cells with four (alpha, beta, gamma, delta) functional receptor chains.

1988 • 46 citations

At least two non-antigen-binding molecules are required for signal transduction by the T-cell antigen receptor.

1988 • 42 citations

Surface expression of CD3 in the absence of T cell receptor (TcR): evidence for sorting of partial TcR/CD3 complexes in a post‐endoplasmic reticulum compartment

1989 • 37 citations

Independent association of T cell receptor beta and gamma chains with CD3 in the same cell.

1987 • 35 citations

Regions of the T cell receptor alpha and beta chains that are responsible for interactions with CD3.

1991 • 31 citations

Association of the human CD3-zeta chain with the alpha beta-T cell receptor/CD3 complex. Clues from a T cell variant with a mutated T cell receptor-alpha chain.

1990 • 29 citations

A T cell receptor-associated GTP-binding protein triggers T cell receptor-mediated granule exocytosis in cytotoxic T lymphocytes.

1988 • 26 citations

A fraction of CD3 epsilon subunits exists as disulfide-linked dimers in both human and murine T lymphocytes.

1990 • 24 citations

An analysis of the role of guanine nucleotide binding proteins in antigen receptor/CD3 antigen coupling to phospholipase C.

1991 • 18 citations

Mutants in signal transduction through the T-cell antigen receptor.

1990 • 11 citations