Major Histocompatibility Complex Class II-associated Invariant Chain Gene Expression Is Up-regulated by Cooperative Interactions of Sp1 and NF-Y

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Chromosomal Subunits in Active Genes Have an Altered Conformation

1976 • 1,842 citations

Weight matrix descriptions of four eukaryotic RNA polymerase II promoter elements derived from 502 unrelated promoter sequences

1990 • 1,140 citations

The 5′ ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I

1980 • 1,114 citations

In Vivo Footprinting of a Muscle Specific Enhancer by Ligation Mediated PCR

1989 • 972 citations

A multiplicity of CCAAT box-binding proteins

1987 • 745 citations

Activation of the AIDS Retrovirus Promoter by the Cellular Transcription Factor, Sp1

1986 • 741 citations

Human CCAAT-binding proteins have heterologous subunits

1988 • 712 citations

The class II molecules of the human and murine major histocompatibility complex

1984 • 664 citations

Ia expression by vascular endothelium is inducible by activated T cells and by human gamma interferon.

1983 • 638 citations

Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts.

1984 • 579 citations

Sequences and Factors: A Guide to MHC Class-II Transcription

1992 • 540 citations

Synergistic activation by the glutamine-rich domains of human transcription factor Sp1

1989 • 539 citations

A cooperative interaction between NF-kappa B and Sp1 is required for HIV-1 enhancer activation.

1993 • 480 citations

Regulation of Major Histocompatibility Complex Class-II Genes: X, Y and Other Letters of the Alphabet

1990 • 470 citations

Steroid-dependent interaction of transcription factors with the inducible promoter of mouse mammary tumor virus in vivo

1987 • 448 citations

Genes of the Major Histocompatibility Complex of the Mouse

1983 • 445 citations

A 200 base pair region at the 5$prime; end of the chicken adult $beta;-globin gene is accessible to nuclease digestion

1981 • 443 citations

Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes

1994 • 442 citations

Isolation and characterization of the intracellular MHC class II compartment

1994 • 426 citations

Mice lacking the MHC class II-associated invariant chain

1993 • 385 citations

Antigen processing and class II MHC peptide-loading compartments in human B-lymphoblastoid cells

1994 • 349 citations

Occupation of the c-fos serum response element in vivo by a multi-protein complex is unaltered by growth factor induction

1989 • 346 citations

Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain

1991 • 326 citations

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.

1993 • 326 citations

Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription

1991 • 311 citations

Evidence for physical interaction between the zinc-finger transcription factors YY1 and Sp1.

1993 • 310 citations

Recombinant rat CBF-C, the third subunit of CBF/NFY, allows formation of a protein-DNA complex with CBF-A and CBF-B and with yeast HAP2 and HAP3.

1995 • 299 citations

Interaction between transcription factors Spl and YY1

1993 • 282 citations

Co-evolution from yeast to mouse: cDNA cloning of the two NF-Y (CP-1/CBF) subunits.

1990 • 264 citations

A yeast and a human CCAAT-binding protein have heterologous subunits that are functionally interchangeable

1988 • 263 citations

In vivo footprint and methylation analysis by PCR-aided genomic sequencing: comparison of active and inactive X chromosomal DNA at the CpG island and promoter of human PGK-1.

1990 • 250 citations

Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc.

1993 • 245 citations

Surface antigens of melanoma and melanocytes. Specificity of induction of Ia antigens by human gamma-interferon.

1984 • 224 citations

Separation of subcellular compartments containing distinct functional forms of MHC class II.

1994 • 221 citations

Regulation of MHC gene expression

1993 • 215 citations

Conserved major histocompatibility complex class II boxes--X and Y--are transcriptional control elements and specifically bind nuclear proteins.

1987 • 212 citations

Selective Activation of Transcription by a Novel CCAAT Binding Factor

1988 • 206 citations

Synergism in transcriptional activation: a kinetic view.

1993 • 196 citations

Specific recognition nucleotides and their DNA context determine the affinity of E2 protein for 17 binding sites in the BPV-1 genome.

1989 • 195 citations

Monoclonal antibodies to NF-Y define its function in MHC class II and albumin gene transcription.

1992 • 192 citations

A trans-acting class II regulatory gene unlinked to the MHC controls expression of HLA class II genes

1985 • 191 citations

Assembly and transport properties of invariant chain trimers and HLA-DR-invariant chain complexes.

1992 • 189 citations

Synergistic activation of the HTLV1 LTR Ets-responsive region by transcription factors Ets1 and Sp1.

1993 • 180 citations

Function of major histocompatibility complex class II promoters requires cooperative binding between factors RFX and NF-Y.

1994 • 176 citations

In vivo footprinting of MHC class II genes: bare promoters in the bare lymphocyte syndrome

1991 • 175 citations

Differential expression of Ia and Ia-associated invariant chain in mouse tissues after in vivo treatment with IFN-gamma.

1986 • 164 citations

CCAAT box binding protein NF-Y facilitates in vivo recruitment of upstream DNA binding transcription factors.

1994 • 139 citations

Interleukin-2 Transcription Is Regulated In Vivo at the Level of Coordinated Binding of Both Constitutive and Regulated Factors

1994 • 138 citations

Three different polypeptides are necessary for DNA binding of the mammalian heteromeric CCAAT binding factor.

1992 • 138 citations

A ubiquitous factor is required for C/EBP-related proteins to form stable transcription complexes on an albumin promoter segment in vitro.

1992 • 138 citations

A Y-box consensus sequence is required for basal expression of the human multidrug resistance (mdr1) gene.

1993 • 124 citations

A novel cis-acting element controlling the rat CYP2D5 gene and requiring cooperativity between C/EBP beta and an Sp1 factor.

1994 • 117 citations

Synergistic activation of a human promoter in vivo by transcription factor Sp1.

1991 • 115 citations

Cooperative interactions between transcription factors Sp1 and OTF-1.

1990 • 114 citations

In vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reaction.

1992 • 95 citations

A serum response element and a binding site for NF-Y mediate the serum response of the human thrombospondin 1 gene.

1993 • 85 citations

Partial purification of a nuclear protein that binds to the CCAAT box of the mouse alpha 1-globin gene.

1986 • 83 citations

MHC class II antigen processing: biology of invariant chain

1994 • 83 citations

Chemistry and functional role of the invariant chain

1992 • 76 citations

Stereospecific alignment of the X and Y elements is required for major histocompatibility complex class II DRA promoter function.

1991 • 74 citations

Affinity-purified CCAAT-box-binding protein (YEBP) functionally regulates expression of a human class II major histocompatibility complex gene and the herpes simplex virus thymidine kinase gene.

1991 • 73 citations

Response of glioma cells to interferon‐gamma: increase in class II RNA, protein and mixed lymphocyte reaction‐stimulating ability

1985 • 70 citations

Coordinate induction of Ia alpha, beta, and Ii mRNA in a macrophage cell line.

1985 • 69 citations

In vivo footprint analysis of the HLA-DRA gene promoter: cell-specific interaction at the octamer site and up-regulation of X box binding by interferon gamma.

1992 • 69 citations

Tumor necrosis factor alpha regulates expression of the major histocompatibility complex class II-associated invariant chain by binding of an NF-kappa B-like factor to a promoter element.

1990 • 68 citations

Interleukin-2 transcription is regulated in vivo at the level of coordinated binding of both constitutive and regulated factors.

1994 • 67 citations

Differential expression of the invariant chain in mouse tumor cells: relationship to B lymphoid development.

1984 • 66 citations

Class II box consensus sequences in the HLA-DR alpha gene: transcriptional function and interaction with nuclear proteins.

1989 • 63 citations

Function of NF-κB/Rel Binding Sites in the Major Histocompatibility Complex Class II Invariant Chain Promoter Is Dependent on Cell-Specific Binding of Different NF-κB/Rel Subunits

1994 • 62 citations

Ia antigens and associated invariant chain are induced simultaneously in lines of T-dependent mast cells by recombinant interferon-gamma.

1984 • 55 citations

Transcription factor binding and spacing constraints in the human β-actin proximal promoter

1991 • 53 citations

Rous sarcoma virus enhancer factor I is a ubiquitous CCAAT transcription factor highly related to CBF and NF-Y.

1990 • 48 citations

Multiple mechanisms regulate the proliferation-specific histone gene transcription factor HiNF-D in normal human diploid fibroblasts

1992 • 42 citations

Human major histocompatibility complex class II-associated invariant chain gene promoter. Functional analysis and in vivo protein/DNA interactions of constitutive and IFN-gamma-induced expression.

1993 • 42 citations

Sequences homologous to class II MHC W, X, and Y elements mediate constitutive and IFN-gamma-induced expression of human class II-associated invariant chain gene.

1991 • 38 citations

Invariant chain — a regulator of antigen presentation

1992 • 38 citations

Function of NF-kappa B/Rel binding sites in the major histocompatibility complex class II invariant chain promoter is dependent on cell-specific binding of different NF-kappa B/Rel subunits.

1994 • 37 citations

Transcriptional control of the invariant chain gene involves promoter and enhancer elements common to and distinct from major histocompatibility complex class II genes.

1990 • 36 citations

Nonimmune human cells can express MHC class II antigens in the absence of invariant chain--an immunohistological study on normal and chronically inflamed small intestine.

1988 • 34 citations

Interferon-gamma-inducible regulation of the human invariant chain gene

1991 • 32 citations

Questions of presentation

1990 • 31 citations

Characterization of a high affinity octamer transcription factor binding site in the human lipoprotein lipase promoter

1992 • 30 citations

Differential suppression of interferon-γ-induced Ia antigen expression on cultured rat astroglia and microglia by second messengers☆

1990 • 28 citations

The IFN-gamma response of the murine invariant chain gene is mediated by a complex enhancer that includes several MHC class II consensus elements.

1990 • 28 citations

Regulation of MHC class II invariant chain expression: induction of synthesis in human and murine plasmocytoma cells by arresting replication.

1983 • 27 citations

Transcriptional regulation of HLA class-II genes

1990 • 25 citations

Activation of the beta-globin promoter by the locus control region correlates with binding of a novel factor to the CAAT box in murine erythroleukemia cells but not in K562 cells.

1993 • 24 citations

Regulation of the class II-associated invariant chain gene in normal and mutant B lymphocytes.

1990 • 22 citations

Two liver-enriched trans-acting factors support the tissue-specific basal transcription from the rat tyrosine aminotransferase promoter

1992 • 11 citations