Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter

1983 • 1,471 citations

Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif

1988 • 1,403 citations

GAL4-VP16 is an unusually potent transcriptional activator

1988 • 1,379 citations

Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element

1990 • 1,326 citations

Affinity purification of sequence-specific DNA binding proteins.

1986 • 1,255 citations

Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins

1985 • 1,248 citations

A cellular DNA-binding protein that activates eukaryotic transcription and DNA replication

1987 • 1,050 citations

Mechanism of transcriptional activation by Sp1: Evidence for coactivators

1990 • 1,029 citations

Positive and negative regulation of transcription in vitro: Enhancer-binding protein AP-2 is inhibited by SV40 T antigen

1987 • 969 citations

Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression.

1988 • 830 citations

GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase

1990 • 677 citations

Transcription activation by the adenovirus E1a protein

1989 • 667 citations

Synergistic activation by the glutamine-rich domains of human transcription factor Sp1

1989 • 539 citations

ADENOVIRUS PROMOTERS AND E1A TRANSACTIVATION

1986 • 460 citations

The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16

1989 • 434 citations

Transactivation of a bovine papilloma virus transcriptional regulatory element by the E2 gene product

1985 • 402 citations

Targeting the E1 Replication Protein to the Papillomavirus Origin of Replication by Complex Formation with the E2 Transactivator

1990 • 396 citations

A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a protein

1990 • 391 citations

A mechanism for synergistic activation of a mammalian gene by GAL4 derivatives

1990 • 386 citations

A herpesvirus trans-activating protein interacts with transcription factor OTF-1 and other cellular proteins.

1988 • 381 citations

The yeast UASG is a transcriptional enhancer in human hela cells in the presence of the GAL4 trans-activator

1988 • 362 citations

GAL4 activates gene expression in mammalian cells

1988 • 355 citations

DNA looping between sites for transcriptional activation: self-association of DNA-bound Sp1.

1991 • 348 citations

Bovine papillomavirus E2 trans-activating gene product binds to specific sites in papillomavirus DNA

1987 • 330 citations

Molecular cloning and characterization of a human DNA binding factor that represses transcription

1989 • 285 citations

A cellular protein, activating transcription factor, activates transcription of multiple E1A-inducible adenovirus early promoters.

1987 • 284 citations

A transcriptional repressor encoded by BPV-1 shares a common carboxy-terminal domain with the E2 transactivator

1987 • 278 citations

GAL4 derivatives function alone and synergistically with mammalian activators in vitro

1988 • 274 citations

How different eukaryotic transcriptional activators can cooperate promiscuously

1990 • 261 citations

Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors

1990 • 247 citations

Cooperativity and hierarchical levels of functional organization in the SV40 enhancer

1988 • 238 citations

Structural and mutational analysis of E2 trans-activating proteins of papillomaviruses reveals three distinct functional domains.

1988 • 213 citations

Specific recognition nucleotides and their DNA context determine the affinity of E2 protein for 17 binding sites in the BPV-1 genome.

1989 • 195 citations

Differential promoter utilization by the bovine papillomavirus in transformed cells and productively infected wart tissues.

1987 • 192 citations

Activation of the U2 snRNA promoter by the octamer motif defines a new class of RNA polymerase II enhancer elements.

1988 • 174 citations

Nuclear factor ETF specifically stimulates transcription from promoters without a TATA box

1989 • 162 citations

Bovine papillomavirus transcriptional regulation: localization of the E2-responsive elements of the long control region

1987 • 160 citations

Use of polylysine for adsorption of nuclei acids and enzymes to electron microscope specimen films.

1977 • 153 citations

Trans-activation of an upstream early gene promoter of bovine papilloma virus-1 by a product of the viral E2 gene.

1987 • 138 citations

The carboxy-terminal domain shared by the bovine papillomavirus E2 transactivator and repressor proteins contains a specific DNA binding activity.

1988 • 136 citations

Bovine papillomavirus type 1 encodes two forms of a transcriptional repressor: structural and functional analysis of new viral cDNAs

1989 • 130 citations

Dissociation of transforming and trans-activation functions for bovine papillomavirus type 1

1985 • 129 citations

The hepatitis B virus-encoded transcriptional trans-activator hbx appears to be a novel protein serine/threonine kinase

1990 • 121 citations

Messenger RNAs from the transforming region of bovine papilloma virus type I

1985 • 120 citations

Association of DNA-bound progesterone receptors

1987 • 116 citations

The E6/E7 promoter of human papillomavirus type 16 is activated in the absence of E2 proteins by a sequence-aberrant Sp1 distal element

1990 • 114 citations

A dimer of BPV-1 E2 containing a protease resistant core interacts with its DNA target.

1988 • 99 citations

The E2 "gene" of bovine papillomavirus encodes an enhancer-binding protein.

1987 • 98 citations

Functional mapping of the human papillomavirus type 11 transcriptional enhancer and its interaction with the trans-acting E2 proteins.

1988 • 93 citations

Sequence-specific and general transcriptional activation by the bovine papillomavirus-1 E2 trans-activator require an N-terminal amphipathic helix-containing E2 domain.

1988 • 81 citations

The activation domain of the bovine papillomavirus E2 protein mediates association of DNA-bound dimers to form DNA loops.

1991 • 78 citations

Specific stimulation of simian virus 40 late transcription in vitro by a cellular factor binding the simian virus 40 21-base-pair repeat promoter element.

1987 • 77 citations

Transcriptional enhancers can act in trans

1990 • 75 citations

Mutations that increase the activity of a transcriptional activator in yeast and mammalian cells.

1990 • 73 citations

Cooperative activation of transcription by bovine papillomavirus type 1 E2 can occur over a large distance.

1990 • 66 citations

The E2 trans-activator can act as a repressor by interfering with a cellular transcription factor.

1990 • 65 citations

The bovine papillomavirus P2443 promoter is E2 trans-responsive: evidence for E2 autoregulation.

1988 • 65 citations

Evidence for cooperativity between E2 binding sites in E2 trans-regulation of bovine papillomavirus type 1

1988 • 52 citations

Characterization of the cis elements involved in basal and E2-transactivated expression of the bovine papillomavirus P2443 promoter

1991 • 43 citations

trans Activation of the simian virus 40 enhancer.

1986 • 40 citations

Eukaryotic transcription. The role of cis- and trans-acting elements in initiation

1986 • 39 citations

Bovine papillomavirus E2 gene regulates expression of the viral E5 transforming gene

1988 • 39 citations

Bovine papilloma virus encoded E2 protein activates lymphokine genes through DNA elements, distinct from the consensus motif, in the long control region of its own genome.

1989 • 37 citations

Mutational analysis of the 3' open reading frames and the splice junction at nucleotide 3225 of bovine papillomavirus type 1

1987 • 36 citations

The E2 transactivator of bovine papillomavirus type 1 is expressed from multiple promoters

1990 • 22 citations