Synergism in transcriptional activation: a kinetic view.

Enzyme structure and mechanism

1977 • 2,935 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

Kinetic Proofreading: A New Mechanism for Reducing Errors in Biosynthetic Processes Requiring High Specificity

1974 • 1,532 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

Chromatin as an essential part of the transcriptional mechanim

1992 • 853 citations

Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID

1990 • 620 citations

Mechanism of action of an acidic transcriptional activator in vitro

1991 • 557 citations

Transcription factor ATF interacts with the TATA factor to facilitate establishment of a preinitiation complex

1988 • 488 citations

Enzyme structure and mechanism (2nd edn)

1985 • 484 citations

Messenger RNA Splicing in Yeast: Clues to Why the Spliceosome Is a Ribonucleoprotein

1991 • 433 citations

Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II

1992 • 407 citations

A mechanism for synergistic activation of a mammalian gene by GAL4 derivatives

1990 • 386 citations

Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription

1992 • 379 citations

Binding of general transcription factor TFIIB to an acidic activating region

1991 • 377 citations

Modularity in promoters and enhancers

1989 • 366 citations

Reduced binding of TFIID to transcriptionally compromised mutants of VP16

1991 • 362 citations

Synergistic activation and repression of transcription by Drosophila homeobox proteins

1989 • 353 citations

Partition analysis and concept of net rate constants as tools in enzyme kinetics

1975 • 323 citations

Physical Analysis of Transcription Preinitiation Complex Assembly on a Class II Gene Promoter

1988 • 320 citations

Family of proteins that interact with TFIID and regulate promoter activity

1991 • 319 citations

Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription

1991 • 311 citations

Separation and partial characterization of three functional steps in transcription initiation by human RNA polymerase II.

1985 • 311 citations

The estrogen-responsive element as an inducible enhancer: DNA sequence requirements and conversion to a glucocorticoid-responsive element.

1987 • 268 citations

How different eukaryotic transcriptional activators can cooperate promiscuously

1990 • 261 citations

Factors involved in specific transcription by mammalian RNA polymerase II: role of transcription factors IIA, IID, and IIB during formation of a transcription-competent complex.

1990 • 255 citations

Cooperative binding of drosophila heat shock factor to arrays of a conserved 5 bp unit

1991 • 250 citations

Glucocorticoid receptor-mediated suppression of the interleukin 2 gene expression through impairment of the cooperativity between nuclear factor of activated T cells and AP-1 enhancer elements.

1992 • 246 citations

Cooperativity and hierarchical levels of functional organization in the SV40 enhancer

1988 • 238 citations

Functional steps in transcription initiation and reinitiation from the major late promoter in a HeLa nuclear extract.

1987 • 228 citations

Cooperative DNA binding of the yeast transcriptional activator GAL4.

1988 • 227 citations

Polymerase II Promoter Activation: Closed Complex Formation and ATP-Driven Start Site Opening

1992 • 220 citations

Phosphorylation of RNA polymerase IIA occurs subsequent to interaction with the promoter and before the initiation of transcription.

1990 • 178 citations

EFTu provides an internal kinetic standard for translational accuracy

1988 • 176 citations

Irresistible force meets immovable object: Transcription and the nucleosome

1991 • 175 citations

An upstream transcription factor, USF (MLTF), facilitates the formation of preinitiation complexes during in vitro chromatin assembly.

1990 • 162 citations

The acidic activator GAL4-AH can stimulate polymerase II transcription by promoting assembly of a closed complex requiring TFIID and TFIIA.

1992 • 160 citations

Advances in RNA polymerase II transcription

1992 • 149 citations

Advances in RNA polymerase II transcription

1992 • 144 citations

Assembly and disassembly of the Drosophila RNA polymerase II complex during transcription.

1990 • 134 citations

Exonucleolytic proofreading

1988 • 133 citations

Transcription initiation by RNA polymerase II in vitro. Properties of preinitiation, initiation, and elongation complexes.

1987 • 132 citations

The acidic transcriptional activator GAL-VP16 acts on preformed template-committed complexes.

1992 • 125 citations

Sp1 activates transcription without enhancing DNA-binding activity of the TATA box factor.

1989 • 123 citations

Cooperative interactions between transcription factors Sp1 and OTF-1.

1990 • 114 citations

Factors involved in specific transcription by mammalian RNA polymerase II

1989 • 93 citations

Differential regulation of transcription preinitiation complex assembly by activator and repressor homeo domain proteins.

1992 • 78 citations

A plant DNA-binding protein increases the number of active preinitiation complexes in a human in vitro transcription system.

1990 • 78 citations

Cloning of a Subunit of Yeast RNA Oolymerase II Transcription Factor b and CTD Kinase

1992 • 77 citations

Promoter-dependent phosphorylation of RNA polymerase II by a template-bound kinase. Association with transcriptional initiation

1991 • 73 citations

Initiation of eukaryotic messenger RNA synthesis.

1991 • 57 citations

Physical chemistry with biological applications

1978 • 48 citations

A downstream-element-binding factor facilitates assembly of a functional preinitiation complex at the simian virus 40 major late promoter.

1990 • 42 citations

Proofreading, NTPases and translation: constraints on accurate biochemistry

1992 • 30 citations

Serum response factor affects preinitiation complex formation by TFIID in vitro.

1991 • 27 citations