Metabolic acidosis stimulates muscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

A simple, rapid, and sensitive DNA assay procedure

1980 • 5,006 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1984 • 4,899 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

THE UBIQUITIN SYSTEM FOR PROTEIN DEGRADATION

1992 • 1,402 citations

HINDLIMB MUSCLE FIBER POPULATIONS OF FIVE MAMMALS

1973 • 1,133 citations

Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages.

1981 • 736 citations

Proteolysis, proteasomes and antigen presentation

1992 • 576 citations

The mechanism and functions of ATP‐dependent proteases in bacterial and animal cells

1992 • 450 citations

Proteasomes: multicatalytic proteinase complexes

1993 • 395 citations

Metabolic acidosis stimulates protein degradation in rat muscle by a glucocorticoid-dependent mechanism.

1986 • 363 citations

Glucocorticoids activate the ATP-ubiquitin-dependent proteolytic system in skeletal muscle during fasting

1993 • 341 citations

Mechanisms for defects in muscle protein metabolism in rats with chronic uremia. Influence of metabolic acidosis.

1987 • 323 citations

Role of different proteolytic systems in the degradation of muscle proteins during denervation atrophy.

1990 • 294 citations

Attainment and Maintenance of Normal Stature with Alkali Therapy in Infants and Children with Classic Renal Tubular Acidosis

1978 • 280 citations

Molecular determinants of protein half‐lives in eukaryotic cells

1987 • 268 citations

Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs.

1986 • 245 citations

Natural substrates of the Ubiquitin proteolytic pathway

1991 • 238 citations

Plasma and muscle free amino acids in maintenance hemodialysis patients without protein malnutrition

1990 • 213 citations

Endocrine regulation of protein breakdown in skeletal muscle

1988 • 199 citations

The effect of the correction of metabolic acidosis on nitrogen and potassium balance of patients with chronic renal failure

1984 • 198 citations

Acidosis, not azotemia, stimulates branched-chain, amino acid catabolism in uremic rats

1987 • 180 citations

Ammonium chloride-induced acidosis increases protein breakdown and amino acid oxidation in humans

1992 • 173 citations

Ubiquftin mRNA is a major stress-induced transcript in mammalian cells

1989 • 157 citations

Branched-chain amino acid metabolism in rat muscle: abnormal regulation in acidosis

1987 • 140 citations

The human ubiquitin-52 amino acid fusion protein gene shares several structural features with mammalian ribosomal protein genes

1991 • 137 citations

Skeletal muscle and liver contain a soluble ATP + ubiquitin-dependent proteolytic system

1987 • 132 citations

The activation of protein degradation in muscle by Ca2+ or muscle injury does not involve a lysosomal mechanism

1986 • 122 citations

Activation of the ubiquitin-ATP-dependent proteolytic system in skeletal muscle during fasting and denervation atrophy.

1991 • 122 citations

Regulation of gene expression of proteasomes (multi-protease complexes) during growth and differentiation of human hematopoietic cells.

1992 • 111 citations

Abnormalities in protein synthesis and degradation induced by extracellular pH in BC3H1 myocytes

1991 • 101 citations

The Ubiquitin System for Protein Degradation

1992 • 97 citations

Molecular cloning of cDNA for proteasomes (multicatalytic proteinase complexes) from rat liver: primary structure of the largest component (C2)

1989 • 86 citations

Regulation of protein degradation in muscle by calcium. Evidence for enhanced nonlysosomal proteolysis associated with elevated cytosolic calcium.

1985 • 83 citations

Comparison of protein synthesis and degradation in incubated and perfused muscle

1983 • 69 citations

Chronic metabolic acidosis accelerates whole body proteolysis and oxidation in awake rats

1992 • 67 citations

Skeletal muscle degradation and nitrogen wasting in rats with chronic metabolic acidosis

1991 • 61 citations

In vitro proteolytic processing of a diubiquitin and a truncated diubiquitin formed from in vitro-generated mRNAs.

1988 • 41 citations

Effects of calcium on protein turnover of incubated muscles from mdx mice

1991 • 39 citations

The role of increased proteolysis in the atrophy and arrest of proliferation in serum‐deprived fibroblasts

1984 • 36 citations

The NH₂‐terminal residues of rat liver proteasome (multicatalytic proteinase complex) subunits, C2, C3 and C8, are Nα‐acetylated

1990 • 31 citations

The mechanism and functions of ATP-dependent proteases in bacterial and animal cells

1993 • 24 citations

Down‐regulation of ubiquitin gene expression during differentiation of human leukemia cells

1993 • 23 citations

Plasma nonesterified fatty acids in the Dahl rat. Response to salt loading.

1987 • 7 citations