The acidosis of chronic renal failure activates muscle proteolysis in rats by augmenting transcription of genes encoding proteins of the ATP-dependent ubiquitin-proteasome pathway.

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

THE UBIQUITIN SYSTEM FOR PROTEIN DEGRADATION

1992 • 1,402 citations

HINDLIMB MUSCLE FIBER POPULATIONS OF FIVE MAMMALS

1973 • 1,133 citations

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

1995 • 885 citations

Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages.

1981 • 736 citations

Proteolysis, proteasomes and antigen presentation

1992 • 576 citations

Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85

1984 • 533 citations

Metabolic acidosis stimulates muscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes.

1994 • 394 citations

Metabolic acidosis stimulates protein degradation in rat muscle by a glucocorticoid-dependent mechanism.

1986 • 363 citations

The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression

1995 • 354 citations

Methods for assessing nutritional status of patients with renal failure

1980 • 342 citations

Glucocorticoids activate the ATP-ubiquitin-dependent proteolytic system in skeletal muscle during fasting

1993 • 341 citations

Mechanisms for defects in muscle protein metabolism in rats with chronic uremia. Influence of metabolic acidosis.

1987 • 323 citations

Functions of the Proteasome: the Lysis at the End of the Tunnel

1995 • 302 citations

Increase in levels of polyubiquitin and proteasome mRNA in skeletal muscle during starvation and denervation atrophy

1995 • 294 citations

Molecular determinants of protein half‐lives in eukaryotic cells

1987 • 268 citations

Activation of the ATP-ubiquitin-proteasome pathway in skeletal muscle of cachectic rats bearing a hepatoma

1995 • 263 citations

Sepsis stimulates nonlysosomal, energy-dependent proteolysis and increases ubiquitin mRNA levels in rat skeletal muscle.

1994 • 256 citations

Natural substrates of the Ubiquitin proteolytic pathway

1991 • 238 citations

Increased ATP-ubiquitin-dependent proteolysis in skeletal muscles of tumor-bearing rats.

1994 • 210 citations

Endocrine regulation of protein breakdown in skeletal muscle

1988 • 199 citations

Acidosis and glucocorticoids concomitantly increase ubiquitin and proteasome subunit mRNAs in rat muscle

1994 • 184 citations

Acidosis, not azotemia, stimulates branched-chain, amino acid catabolism in uremic rats

1987 • 180 citations

Why are dialysis patients malnourished?

1995 • 173 citations

Skeletal muscle protein synthesis and degradation in patients with chronic renal failure

1994 • 143 citations

Muscle protein waste in tumor-bearing rats is effectively antagonized by a beta 2-adrenergic agonist (clenbuterol). Role of the ATP-ubiquitin-dependent proteolytic pathway.

1995 • 141 citations

Metabolic acidosis and skeletal muscle adaptation to low protein diets in chronic uremia

1991 • 129 citations

The activation of protein degradation in muscle by Ca2+ or muscle injury does not involve a lysosomal mechanism

1986 • 122 citations

Activation of the ubiquitin-ATP-dependent proteolytic system in skeletal muscle during fasting and denervation atrophy.

1991 • 122 citations

The ATP dependence of the degradation of short- and long-lived proteins in growing fibroblasts.

1985 • 113 citations

Inhibition of the proteolytic activity of the multicatalytic proteinase complex (proteasome) by substrate-related peptidyl aldehydes.

1994 • 112 citations

Body Composition in Chronic Renal Failure<xref ref-type="fn" rid="fn1"><sup>1</sup></xref>

1972 • 104 citations

Burn injury stimulates multiple proteolytic pathways in skeletal muscle, including the ubiquitin-energy-dependent pathway.

1995 • 99 citations

The Ubiquitin System for Protein Degradation

1992 • 97 citations

Epitrochlearis muscle. I. Mechanical performance, energetics, and fiber composition

1980 • 96 citations

Muscle protein turnover and glucose uptake in acutely uremic rats. Effects of insulin and the duration of renal insufficiency.

1983 • 82 citations

Comparison of protein synthesis and degradation in incubated and perfused muscle

1983 • 69 citations

Metabolic acidosis and uremic toxicity: protein and amino acid metabolism.

1994 • 52 citations

Experimental acidemia and muscle cell pH in chronic acidosis and renal failure

1995 • 40 citations

Effects of calcium on protein turnover of incubated muscles from mdx mice

1991 • 39 citations

Dietary protein deficiency reduces lysosomal and nonlysosomal ATP-dependent proteolysis in muscle

1992 • 37 citations

Leucine-Induced Amino Acid Antagonism in Rats: Muscle Valine Metabolism and Growth Impairment

1991 • 32 citations

Kinetics of system A amino acid uptake by muscle: effects of insulin and acute uremia

1990 • 20 citations

Na pump defects in chronic uremia cannot be attributed to changes in Na-K-ATPase mRNA or protein

1994 • 16 citations