The activation of protein degradation in muscle by Ca2+ or muscle injury does not involve a lysosomal mechanism

Proteinases in mammalian cells and tissues

1978 • 981 citations

A fluorometric method for the estimation of tyrosine in plasma and tissues.

1957 • 973 citations

Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm.

1975 • 916 citations

Stimulation of Muscle Protein Degradation and Prostaglandin E₂Release by Leukocytic Pyrogen (Interleukin-1)

1983 • 689 citations

Mechanisms of Intracellular Protein Breakdown

1982 • 647 citations

Inhibition of the Lysosomal Pathway of Protein Degradation in Isolated Rat Hepatocytes by Ammonia, Methylamine, Chloroquine and Leupeptin

1979 • 466 citations

[55] Structures and activities of protease inhibitors of microbial origin

1976 • 445 citations

Does leucine, leucyl-tRNA, or some metabolite of leucine regulate protein synthesis and degradation in skeletal and cardiac muscle?

1982 • 445 citations

Excitation-Contraction Coupling

1976 • 355 citations

Leupeptin, a Protease Inhibitor, Decreases Protein Degradation in Normal and Diseased Muscles

1978 • 267 citations

Quantitative relationship between autophagy and proteolysis during graded amino acid deprivation in perfused rat liver.

1981 • 223 citations

Inhibition of protein degradation in isolated rat hepatocytes

1977 • 214 citations

Purification and characterization of a multicatalytic high-molecular-mass proteinase from rat skeletal muscle

1985 • 208 citations

Pathogenesis of Human Muscular Dystrophies.

1978 • 199 citations

The effects of denervation on protein turnover of rat skeletal muscle

1976 • 180 citations

The stimulation of protein degradation in muscle by Ca2+ is mediated by prostaglandin E2 and does not require the calcium-activated protease.

1982 • 179 citations

Calcium-dependent regulation of protein synthesis and degradation in muscle

1979 • 160 citations

The ATP dependence of the degradation of short- and long-lived proteins in growing fibroblasts.

1985 • 113 citations

Intracellular calcium and pathogenesis and antenatal diagnosis of Duchenne muscular dystrophy.

1980 • 101 citations

[49] Calcium-activated proteases in mammalian tissues

1981 • 96 citations

Regulation of protein degradation in muscle by calcium. Evidence for enhanced nonlysosomal proteolysis associated with elevated cytosolic calcium.

1985 • 83 citations

Calcium Regulation in Biological Systems

1985 • 82 citations

Inhibition of basal and deprivation-induced proteolysis by leupeptin and pepstatin in perfused rat liver and heart

1979 • 61 citations

Vanadate inhibits the ATP-dependent degradation of proteins in reticulocytes without affecting ubiquitin conjugation.

1984 • 61 citations

The effects of calcium on protein turnover in skeletal muscles of the rat

1982 • 60 citations

Degradative Processes in Heart and Skeletal Muscle

1981 • 60 citations

Age-related changes in protein turnover and ribonucleic acid of the diaphragm muscle of normal and dystrophic hamsters

1977 • 49 citations

The effects of calcium ions, ionophore A23187 and inhibition of energy metabolism on protein degradation in the rat diaphragm and epitrochlearis muscles in vitro

1980 • 49 citations

Effects of insulin and anchorage on hepatocytic protein metabolism and amino acid transport

1981 • 49 citations

Comparison of the control and pathways for degradation of the acetylcholine receptor and average protein in cultured muscle cells

1981 • 37 citations

Increased muscle calcium A possible cause of mitochondrial dysfunction and cellular necrosis in denervated rat skeletal muscle

1981 • 37 citations

The role of increased proteolysis in the atrophy and arrest of proliferation in serum‐deprived fibroblasts

1984 • 36 citations

The effects of cutting or of stretching skeletal muscle in vitro on the rates of protein synthesis and degradation

1980 • 27 citations

Intracellular Protein Catabolism

1978 • 24 citations

Role of thyroid, insulin and corticosteroid hormones in the physiological regulation of proteolysis in muscle.

1985 • 20 citations

Effects of amino acid methyl esters on cardiac lysosomes and protein degradation

1983 • 14 citations

Serine proteinases and protein breakdown in muscle.

1985 • 8 citations

ATP-dependent proteolysis in erythroid and muscle cells.

1981 • 8 citations

Biochemical and morphological observations of skeletal muscles incubated in vitro.

1985 • 7 citations

Biochemical and morphological observations of skeletal muscles incubated in vitro.

1985 • 5 citations