Ubiquitin gene expression is increased in skeletal muscle of tumour‐bearing rats

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Cachectin and tumour necrosis factor as two sides of the same biological coin

1986 • 1,659 citations

A fluorometric method for the estimation of tyrosine in plasma and tissues.

1957 • 973 citations

Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation.

1988 • 745 citations

Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis.

1980 • 727 citations

Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85

1984 • 533 citations

Ubiquitination

1991 • 430 citations

Ubiquitin is a heat shock protein in chicken embryo fibroblasts.

1985 • 392 citations

The immunochemical detection and quantitation of intracellular ubiquitin-protein conjugates.

1985 • 383 citations

Infusion of tumor necrosis factor/cachectin promotes muscle catabolism in the rat. A synergistic effect with interleukin 1.

1989 • 378 citations

Glucocorticoids activate the ATP-ubiquitin-dependent proteolytic system in skeletal muscle during fasting

1993 • 341 citations

The ubiquitin system: functions and mechanisms

1985 • 298 citations

Demonstration of two distinct high molecular weight proteases in rabbit reticulocytes, one of which degrades ubiquitin conjugates.

1987 • 255 citations

Multiple effects of tumor necrosis factor on lipoprotein lipase in vivo.

1987 • 240 citations

Natural substrates of the Ubiquitin proteolytic pathway

1991 • 238 citations

The Acute Metabolic Effects of Tumor Necrosis Factor Administration in Humans

1987 • 236 citations

The ubiquitin‐mediated proteolytic pathway and mechanisms of energy‐dependent intracellular protein degradation

1984 • 221 citations

Evidence that lysosomes are not involved in the degradation of myofibrillar proteins in rat skeletal muscle

1986 • 221 citations

Interleukin 1 and tumor necrosis factor do not regulate protein balance in skeletal muscle

1987 • 200 citations

Polypetide mediator network

1987 • 200 citations

Endocrine regulation of protein breakdown in skeletal muscle

1988 • 199 citations

Distribution of Cathepsins B and H in Rat Tissues and Peripheral Blood Cells1

1985 • 187 citations

Skeletal muscle metabolism in patients with malignant tumor

1976 • 183 citations

Hypoxia induces glucose transporter expression in endothelial cells

1992 • 177 citations

Acute treatment with tumour necrosis factor-? induces changes in protein metabolism in rat skeletal muscle

1993 • 158 citations

Metabolic Approaches to Cancer Cachexia

1982 • 156 citations

Age dependence of ischaemic heart syndromes and the contribution of haemostatic deviations

1992 • 146 citations

Tumour necrosis factor‐α increases the ubiquitinization of rat skeletal muscle proteins

1993 • 137 citations

Early development of protein metabolic perturbations in the liver and skeletal muscle of tumour-bearing rats. A model system for cancer cachexia

1987 • 134 citations

CANCER CACHEXIA AND GLUCONEOGENESIS

1974 • 124 citations

Metabolic Effects of Tumour Necrosis Factor-α (Cachectin) and Interleukin-1

1989 • 121 citations

Regulation of lipoprotein lipase synthesis by recombinant tumor necrosis factor—The primary regulatory role of the hormone in 3T3-L1 adipocytes

1986 • 113 citations

The ATP dependence of the degradation of short- and long-lived proteins in growing fibroblasts.

1985 • 113 citations

Tumor necrosis factor can induce fever in rats without activating protein breakdown in muscle or lipolysis in adipose tissue.

1988 • 111 citations

The metabolic environment of cancer

1988 • 96 citations

Ubiquitin in stressed chicken embryo fibroblasts.

1988 • 96 citations

Effects of Tumor Necrosis Factor- on Muscle-Protein Turnover in Female Wistar Rats

1993 • 93 citations

The role of cytokines in muscle wasting: Its relation with cancer cachexia

1992 • 75 citations

Loss of ATP-dependent proteolysis with maturation of reticulocytes and erythrocytes.

1982 • 72 citations

Insulin-stimulated α-(methyl)aminoisobutyric acid uptake in skeletal muscle. Evidence for a short-term activation of uptake independent of Na+ electrochemical gradient and protein synthesis

1988 • 57 citations

Comparative effects of tumour necrosis factor-α (cachectin), interleukin-1-β and tumour growth on amino acid metabolism in the rat in vivo. Absorption and tissue uptake of α-amino[1-14C]isobutyrate

1989 • 52 citations

Age-related changes in protein turnover and ribonucleic acid of the diaphragm muscle of normal and dystrophic hamsters

1977 • 49 citations

Tumour necrosis factor α (cachectin) mimics some of the effects of tumour growth on the disposal of a [14C]lipid load in virgin, lactating and litter-removed rats

1988 • 39 citations

The energy state of tumor-bearing rats.

1991 • 38 citations

Comparison of hepatic cathepsin D activity in response to tumor growth and to caloric restriction in mice.

1980 • 28 citations

The effects of tumour necrosis factor-α (cachectin) and tumour growth on hepatic amino acid utilization in the rat

1990 • 26 citations

Chronic tumour necrosis factor-alpha treatment modifies protein turnover in rat tissues.

1993 • 26 citations

Demonstration of cathepsins B, H and L in xenografts of normal and Duchenne-muscular-dystrophy muscles transplanted into nude mice

1992 • 19 citations

A flow cytometric study of the rat Yoshida AH-130 ascites hepatoma

1993 • 14 citations