Functional analysis and intracellular localization of p53 modified by SUMO-1

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

The complexity of p53 modulation: emerging patterns from divergent signals

1998 • 1,319 citations

A Small Ubiquitin-Related Polypeptide Involved in Targeting RanGAP1 to Nuclear Pore Complex Protein RanBP2

1997 • 1,221 citations

A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex.

1996 • 1,161 citations

SUMO-1 Modification of IκBα Inhibits NF-κB Activation

1998 • 1,002 citations

Regulation of p53 in response to DNA damage

1999 • 960 citations

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

2000 • 956 citations

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1993 • 875 citations

Chk2/hCds1 functions as a DNA damage checkpoint in G₁by stabilizing p53

2000 • 781 citations

p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage

1999 • 764 citations

A new protease required for cell-cycle progression in yeast

1999 • 718 citations

Binding and modulation of p53 by p300/CBP coactivators

1997 • 698 citations

Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus

1998 • 676 citations

Recruitment of p300/CBP in p53-Dependent Signal Pathways

1997 • 671 citations

MDM2 — master regulator of the p53 tumor suppressor protein

2000 • 637 citations

SUMO-1 modification activates the transcriptional response of p53

1999 • 627 citations

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein

1998 • 610 citations

Synergistic activation of transcription by CBP and p53

1997 • 599 citations

The cellular response to p53: the decision between life and death

1999 • 594 citations

The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer

1997 • 543 citations

Monoclonal antibodies identify a group of nuclear pore complex glycoproteins.

1987 • 533 citations

Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation

1996 • 508 citations

Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1

1999 • 507 citations

Ubc9p Is the Conjugating Enzyme for the Ubiquitin-like Protein Smt3p

1997 • 488 citations

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

1998 • 471 citations

Regulation of p53 Function and Stability by Phosphorylation

1999 • 443 citations

Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C.

1995 • 410 citations

c-Jun and p53 Activity Is Modulated by SUMO-1 Modification

2000 • 394 citations

Covalent Modification of p73α by SUMO-1

2000 • 376 citations

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2

1999 • 362 citations

Ubch9 conjugates SUMO but not ubiquitin

1997 • 349 citations

Mutations in Human ARF Exon 2 Disrupt Its Nucleolar Localization and Impair Its Ability to Block Nuclear Export of MDM2 and p53

1999 • 343 citations

Evidence for Covalent Modification of the Nuclear Dot–associated Proteins PML and Sp100 by PIC1/SUMO-1

1997 • 329 citations

Nuclear Accumulation of p53 Protein Is Mediated by Several Nuclear Localization Signals and Plays a Role in Tumorigenesis

1990 • 328 citations

Identification of a major polypeptide of the nuclear pore complex.

1982 • 326 citations

Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin.

1996 • 323 citations

Identification of Three Major Sentrinization Sites in PML

1998 • 305 citations

Tumor-suppressor p53: implications for tumor development and prognosis.

1998 • 279 citations

SUMO-1 Modification of Mdm2 Prevents Its Self-Ubiquitination and Increases Mdm2 Ability to Ubiquitinate p53

2000 • 271 citations

Mdm2: keeping p53 under control

1997 • 267 citations

Differential Regulation of Sentrinized Proteins by a Novel Sentrin-specific Protease

2000 • 266 citations

The Nuclear Dot Protein Sp100, Characterization of Domains Necessary for Dimerization, Subcellular Localization, and Modification by Small Ubiquitin-like Modifiers

1999 • 258 citations

Monoclonal autoantibody from a (new zealand black x new zealand white)F₁ mouse and some human scleroderma sera target an MT_r 34,000 nucleolar protein of the U3 RNP particle

1987 • 252 citations

The CaaX motif of lamin A functions in conjunction with the nuclear localization signal to target assembly to the nuclear envelope

1989 • 227 citations

In VitroSUMO-1 Modification Requires Two Enzymatic Steps, E1 and E2

1999 • 224 citations

SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage

2000 • 208 citations

Subcellular fractionation : a practical approach

1997 • 206 citations

Preferential Modification of Nuclear Proteins by a Novel Ubiquitin-like Molecule

1997 • 173 citations

Covalent modification of the homeodomain-interacting protein kinase 2 (HIPK2) by the ubiquitin-like protein SUMO-1

1999 • 160 citations

DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

1999 • 152 citations

A Method for the Rapid Isolation of Nuclear Membranes from Rat Liver

1972 • 147 citations

SUMO-1: wrestling with a new ubiquitin-related modifier

1997 • 143 citations

Associations of UBE2I with RAD52, UBL1, p53, and RAD51 Proteins in a Yeast Two-Hybrid System

1996 • 135 citations

An Inhibitor of Nuclear Export Activates the p53 Response and Induces the Localization of HDM2 and p53 to U1A-Positive Nuclear Bodies Associated with the PODs

1999 • 133 citations

Keeping an old friend under control: regulation of p53 stability

1998 • 122 citations

The adenovirus type 5 E1b 55K and E4 Orf3 proteins associate in infected cells and affect ND10 components.

1999 • 116 citations

Immunolocalization of Human p14ARF to the Granular Component of the Interphase Nucleolus

2000 • 78 citations

A New 30-kDa Ubiquitin-related SUMO-1 Hydrolase from Bovine Brain

1999 • 74 citations

Non-activated p53 co-localizes with sites of transcription within both the nucleoplasm and the nucleolus

2000 • 74 citations

Regulation of double-strand break-induced mammalian homologous recombination by UBL1, a RAD51-interacting protein

2000 • 73 citations

Isolation and characterization of nuclei and nuclear subfractions

1997 • 17 citations

Interaction trap cloning with yeast

1995 • 12 citations