Non-activated p53 co-localizes with sites of transcription within both the nucleoplasm and the nucleolus

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

Human Hepatocellular Carcinoma Cell Lines Secrete the Major Plasma Proteins and Hepatitis B Surface Antigen

1980 • 2,034 citations

Measurement of co‐localization of objects in dual‐colour confocal images

1993 • 1,979 citations

Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line

1979 • 1,305 citations

An Information-Intensive Approach to the Molecular Pharmacology of Cancer

1997 • 1,177 citations

Identification of p53 as a Sequence-Specific DNA-Binding Protein

1991 • 1,109 citations

Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53.

1997 • 749 citations

Mapping of the p53 and mdm-2 interaction domains.

1993 • 658 citations

Fluorescent labeling of nascent RNA reveals transcription by RNA polymerase II in domains scattered throughout the nucleus

1993 • 541 citations

Core filaments of the nuclear matrix.

1990 • 436 citations

Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest.

1996 • 385 citations

Structure and function of the nucleolus

1999 • 380 citations

The Nucleolus

1995 • 356 citations

The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes.

1994 • 300 citations

Inhibition of RNA polymerase II as a trigger for the p53 response

1999 • 287 citations

Negative feedback regulation of wild-type p53 biosynthesis.

1995 • 281 citations

Experimental test of an analytical model of aberration in an oil-immersion objective lens used in three-dimensional light microscopy

1991 • 242 citations

Nuclear distribution of transcription factors in relation to sites of transcription and RNA polymerase II

1997 • 217 citations

Protein translation components are colocalized in granules in oligodendrocytes

1995 • 215 citations

The definition of a large viral transcription unit late in Ad2 infection of HeLa cells: Mapping of nascent RNA molecular labeled in isolated nuclei

1977 • 198 citations

Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: Evidence for the involvement of RNA perturbation

1997 • 195 citations

Poly(A) RNA codistribution with microfilaments: evaluation by in situ hybridization and quantitative digital imaging microscopy.

1992 • 154 citations

p53 represses ribosomal gene transcription

1999 • 151 citations

Thinking about a nuclear matrix

1998 • 144 citations

Quantitative Digital Analysis of Diffuse and Concentrated Nuclear Distributions of Nascent Transcripts, SC35 and Poly(A)

1997 • 114 citations

Cockayne syndrome: defective repair of transcription?

1997 • 113 citations

Modulation of DNA Topoisomerase I Activity by p53

1996 • 103 citations

p53 is covalently linked to 5.8S rRNA.

1992 • 97 citations

Specificity of seven monoclonal antibodies against p53 evaluated with Western blotting, immunohistochemistry, confocal laser scanning microscopy, and flow cytometry.

1997 • 74 citations

Distinct Domains in Ribosomal Protein L5 Mediate 5 S rRNA Binding and Nucleolar Localization

1996 • 67 citations

Specificity of seven monoclonal antibodies against p53 evaluated with Western blotting, immunohistochemistry, confocal laser scanning microscopy, and flow cytometry

1997 • 58 citations

The Localization of Sites Containing Nascent RNA and Splicing Factors

1996 • 58 citations

Transcription Abnormalities Potentiate Apoptosis of Normal Human Fibroblasts

1997 • 58 citations

Functional subnuclear partitioning of transcription factors

1998 • 54 citations

Molecular characterization of the large heavily glycosylated domain glycopeptide from the rat small intestinal Muc2 mucin

1996 • 53 citations

Enhanced three-dimensional reconstruction from confocal scanning microscope images II Depth discrimination versus signal-to-noise ratio in partially confocal images

1994 • 50 citations

p53 Is Covalently Linked to 5.8S rRNA

1992 • 40 citations

Cell‐cycle dependent biosynthesis and localization of p53 protein in untransformed human cells

1995 • 33 citations

Prooxidant and Antioxidant Activities of Macrophages in Metal-Mediated LDL Oxidation

1999 • 20 citations

TURING MACHINE APPROACH TO SOLVE PSYCHROMETRIC ATTRIBUTES

1997 • 14 citations