Centromere proteins and chromosome inheritance: a complex affair

Catalog of chromosome aberrations in cancer

1985 • 1,522 citations

Mutations of mitotic checkpoint genes in human cancers

1998 • 1,482 citations

Feedback control of mitosis in budding yeast

1991 • 1,167 citations

S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function

1991 • 1,125 citations

CDC20 and CDH1 : A Family of Substrate-Specific Activators of APC-Dependent Proteolysis

1997 • 809 citations

Association of Transcriptionally Silent Genes with Ikaros Complexes at Centromeric Heterochromatin

1997 • 792 citations

Association of Spindle Assembly Checkpoint Component XMAD2 with Unattached Kinetochores

1996 • 785 citations

The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores.

1995 • 701 citations

Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis.

1996 • 634 citations

Identification of a Human Mitotic Checkpoint Gene: hsMAD2

1996 • 609 citations

An ESP1/PDS1 Complex Regulates Loss of Sister Chromatid Cohesion at the Metaphase to Anaphase Transition in Yeast

1998 • 594 citations

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

1998 • 590 citations

Budding Yeast Cdc20: A Target of the Spindle Checkpoint

1998 • 561 citations

Kinetochore Localization of Murine Bub1 Is Required for Normal Mitotic Timing and Checkpoint Response to Spindle Damage

1997 • 543 citations

Human T Cell Leukemia Virus Type 1 Oncoprotein Tax Targets the Human Mitotic Checkpoint Protein MAD1

1998 • 528 citations

Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle.

1994 • 511 citations

Localization of cytoplasmic dynein to mitotic spindles and kinetochores

1990 • 508 citations

Cytoplasmic dynein is localized to kinetochores during mitosis

1990 • 486 citations

Direct Binding of CDC20 Protein Family Members Activates the Anaphase-Promoting Complex in Mitosis and G1

1998 • 484 citations

Localization of Mad2 to Kinetochores Depends on Microtubule Attachment, Not Tension

1998 • 475 citations

The case for epigenetic effects on centromere identity and function

1997 • 470 citations

The Human Homologue of Bub3 Is Required for Kinetochore Localization of Bub1 and a Mad3/Bub1-related Protein Kinase

1998 • 460 citations

Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation.

1995 • 447 citations

The vertebrate cell kinetochore and its roles during mitosis

1998 • 437 citations

CENP-E Is a Plus End–Directed Kinetochore Motor Required for Metaphase Chromosome Alignment

1997 • 428 citations

Drosophila fizzy-related Down-Regulates Mitotic Cyclins and Is Required for Cell Proliferation Arrest and Entry into Endocycles

1997 • 421 citations

The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast

1999 • 404 citations

Fission Yeast Slp1: An Effector of the Mad2-Dependent Spindle Checkpoint

1998 • 381 citations

Transient Inhibition of Histone Deacetylation Alters the Structural and Functional Imprint at Fission Yeast Centromeres

1997 • 367 citations

CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis.

1995 • 367 citations

Cse4p Is a Component of the Core Centromere of Saccharomyces cerevisiae

1998 • 365 citations

The Centromere: Hub of Chromosomal Activities

1995 • 353 citations

Kinetochore chemistry is sensitive to tension and may link mitotic forces to a cell cycle checkpoint.

1995 • 344 citations

Immunolocalization of CENP-A suggests a distinct nucleosome structure at the inner kinetochore plate of active centromeres

1997 • 336 citations

Mass Spectrometric Analysis of the Anaphase-Promoting Complex from Yeast: Identification of a Subunit Related to Cullins

1998 • 330 citations

CENP-E Function at Kinetochores Is Essential for Chromosome Alignment

1997 • 326 citations

Spindle Checkpoint Protein Xmad1 Recruits Xmad2 to Unattached Kinetochores

1998 • 307 citations

The Chromodomain Protein Swi6: A Key Component at Fission Yeast Centromeres

1995 • 300 citations

Mitotic Centromere–associated Kinesin Is Important for Anaphase Chromosome Segregation

1998 • 288 citations

Something from nothing: the evolution and utility of satellite repeats

1998 • 283 citations

Characterization of the Kinetochore Binding Domain of CENP-E Reveals Interactions with the Kinetochore Proteins CENP-F and hBUBR1

1998 • 280 citations

The Human Polycomb Group Complex Associates with Pericentromeric Heterochromatin to Form a Novel Nuclear Domain

1998 • 279 citations

ZW10 Helps Recruit Dynactin and Dynein to the Kinetochore

1998 • 256 citations

Molecular Structure of a Functional Drosophila Centromere

1997 • 252 citations

Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin

1998 • 244 citations

APC-Mediated Proteolysis of Ase1 and the Morphogenesis of the Mitotic Spindle

1997 • 243 citations

Mutations in the fission yeast silencing factors clr4 + and rik1 + disrupt the localisation of the chromo domain protein Swi6p and impair centromere function

1996 • 241 citations

Mammalian p55CDC Mediates Association of the Spindle Checkpoint Protein Mad2 with the Cyclosome/Anaphase-promoting Complex, and is Involved in Regulating Anaphase Onset and Late Mitotic Events

1998 • 240 citations

Centromere Protein B Null Mice are Mitotically and Meiotically Normal but Have Lower Body and Testis Weights

1998 • 237 citations

Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast.

1995 • 235 citations

The Microtubule-dependent Motor Centromere–associated Protein E (CENP-E) Is an Integral Component of Kinetochore Corona Fibers That Link Centromeres to Spindle Microtubules

1997 • 231 citations

Mis6, a Fission Yeast Inner Centromere Protein, Acts during G1/S and Forms Specialized Chromatin Required for Equal Segregation

1997 • 225 citations

Activation of the MKK/ERK Pathway during Somatic Cell Mitosis: Direct Interactions of Active ERK with Kinetochores and Regulation of the Mitotic 3F3/2 Phosphoantigen

1998 • 223 citations

Microinjection of Antibody to Mad2 Protein into Mammalian Cells in Mitosis Induces Premature Anaphase

1998 • 215 citations

Fission yeast minichromosome loss mutants mis cause lethal aneuploidy and replication abnormality.

1994 • 211 citations

CENP-C is required for maintaining proper kinetochore size and for a timely transition to anaphase.

1994 • 200 citations

Identification of BIME as a Subunit of the Anaphase-Promoting Complex

1996 • 200 citations

A mammalian homologue of Drosophila heterochromatin protein 1 (HP1) is a component of constitutive heterochromatin

1994 • 196 citations

Fizzy is required for activation of the APC/cyclosome in Xenopus egg extracts

1998 • 196 citations

The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae.

1995 • 180 citations

Localization of CENP-E in the fibrous corona and outer plate of mammalian kinetochores from prometaphase through anaphase

1997 • 176 citations

Budding yeast centromere composition and assembly as revealed by in vivo cross-linking

1997 • 173 citations

Mitosis in vertebrate somatic cells with two spindles: Implications for the metaphase/anaphase transition checkpoint and cleavage

1997 • 170 citations

Chromo-domain proteins: linking chromatin structure to epigenetic regulation

1998 • 170 citations

Heterochromatin protein 1 is required for correct chromosome segregation in Drosophila embryos

1995 • 168 citations

The chromo and SET domains of the Clr4 protein are essential for silencing in fission yeast

1998 • 166 citations

Chromatin containing CENP-A and α-satellite DNA is a major component of the inner kinetochore plate

1997 • 160 citations

Fission Yeast Bub1 Is a Mitotic Centromere Protein Essential for the Spindle Checkpoint and the Preservation of Correct Ploidy through Mitosis

1998 • 156 citations

A Dominant Mutant of Inner Centromere Protein (INCENP), a Chromosomal Protein, Disrupts Prometaphase Congression and Cytokinesis

1998 • 151 citations

Evidence for a Role of CLIP-170 in the Establishment of Metaphase Chromosome Alignment

1998 • 149 citations

Fission yeast cut mutations revisited: control of anaphase

1998 • 147 citations

Targeted disruption of mouse centromere protein C gene leads to mitotic disarray and early embryo death

1998 • 143 citations

Centromeres Take Flight: Alpha Satellite and the Quest for the Human Centromere

1998 • 135 citations

Centromeric Protein B Null Mice Are Viable with No Apparent Abnormalities

1998 • 131 citations

The Drosophila l(1)zw10 gene product, required for accurate mitotic chromosome segregation, is redistributed at anaphase onset.

1992 • 127 citations

Microinjection of mitotic cells with the 3F3/2 anti-phosphoepitope antibody delays the onset of anaphase.

1995 • 127 citations

8 Chromosome Segregation during Meiosis: Building an Unambivalent Bivalent

1997 • 126 citations

Separation of Sister Chromatids in Mitosis Requires the Drosophila pimples Product, a Protein Degraded after the Metaphase/Anaphase Transition

1996 • 125 citations

Mad2 transiently associates with an APC/p55Cdc complex during mitosis

1998 • 125 citations

The Cohesion Protein MEI-S332 Localizes to Condensed Meiotic and Mitotic Centromeres until Sister Chromatids Separate

1998 • 123 citations

Centromeres: proteins, protein complexes, and repeated domains at centromeres of simple eukaryotes

1998 • 122 citations

Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death

1998 • 122 citations

Cut1 is loaded onto the spindle by binding to Cut2 and promotes anaphase spindle movement upon Cut2 proteolysis

1998 • 118 citations

4 The Origin of Numerical Chromosome Abnormalities

1995 • 117 citations

Heterochromatin protein 1 distribution during development and during the cell cycle in Drosophila embryos

1995 • 116 citations

Conservation of the Centromere/Kinetochore Protein ZW10

1997 • 109 citations

The Drosophila POLO kinase localises to multiple compartments of the mitotic apparatus and is required for the phosphorylation of MPM2 reactive epitopes

1998 • 107 citations

Efficient conditional mutation of the vertebrate CENP-C gene

1997 • 104 citations

Cell cycle checkpoints: Arresting progress in mitosis

1997 • 103 citations

Bipolar spindle attachments affect redistributions of ZW10, a Drosophila centromere/kinetochore component required for accurate chromosome segregation.

1996 • 100 citations

The Yeast Nucleolar Protein Cbf5p Is Involved in rRNA Biosynthesis and Interacts Genetically with the RNA Polymerase I Transcription Factor RRN3

1997 • 95 citations

Localization of the Drosophila checkpoint control protein Bub3 to the kinetochore requires Bub1 but not Zw10 or Rod

1998 • 91 citations

Bub1p Kinase Activates the Saccharomyces cerevisiae Spindle Assembly Checkpoint

1998 • 91 citations

The Impact of Aneuploidy Upon Public Health: Mortality and Morbidity Associated with Human Chromosome Abnormalities

1985 • 91 citations

Regulation of B-type cyclin proteolysis by Cdc28-associated kinases in budding yeast

1997 • 86 citations

A mutation in NPS1/STH1, an essential gene encoding a component of a novel chromatin-remodeling complex RSC, alters the chromatin structure of Saccharomyces cerevisiae centromeres

1998 • 86 citations

A Fission Yeast Homolog of CDC20/p55^CDC/Fizzy Is Required for Recovery from DNA Damage and Genetically Interacts with p34^cdc2

1997 • 84 citations

Centromeric Chromatin and Epigenetic Effects in Kinetochore Assembly

1998 • 82 citations

Tension-sensitive kinetochore phosphorylation and the chromosome distribution checkpoint in praying mantid spermatocytes

1997 • 82 citations

Chromosome dynamics: the SMC protein family

1998 • 79 citations

SMC protein complexes and higher-order chromosome dynamics

1998 • 78 citations

Probing the Architecture of a Simple Kinetochore Using DNA–Protein Crosslinking

1997 • 77 citations

CENP-G: a new centromeric protein that is associated with the ?-1 satellite DNA subfamily

1998 • 74 citations

The kar3p and kip2p motors function antagonistically at the spindle poles to influence cytoplasmic microtubule numbers

1998 • 72 citations

In vitro assembly of the CENP‐B/α‐satellite DNA/core histone complex: CENP‐B causes nucleosome positioning

1998 • 69 citations

The product of proliferation disrupter is concentrated at centromeres and required for mitotic chromosome condensation and cell proliferation in Drosophila.

1997 • 68 citations

Faithful Chromosome Transmission Requires Spt4p, a Putative Regulator of Chromatin Structure in Saccharomyces cerevisiae

1996 • 66 citations

A Subunit of the Anaphase-Promoting Complex Is a Centromere-Associated Protein in Mammalian Cells

1998 • 63 citations

Mutational Analysis of the Drosophila Sister-Chromatid Cohesion Protein ORD and Its Role in the Maintenance of Centromeric Cohesion

1997 • 62 citations

Tension-sensitive kinetochore phosphorylation in vitro

1998 • 56 citations

A Centromere DNA-binding Protein from Fission Yeast Affects Chromosome Segregation and Has Homology to Human CENP-B

1997 • 55 citations

Dynamics of the sub-nuclear distribution of Modulo and the regulation of position-effect variegation by nucleolus in Drosophila

1998 • 46 citations

Purification and characterization of a CENP-B homologue protein that binds to the centromeric K-type repeat DNA of Schizosaccharomyces pombe

1997 • 44 citations

Kinetochores distinguish GTP from GDP forms of the microtubule lattice

1997 • 42 citations

The fission yeast chromo domain encoding gene chp1(+) is required for chromosome segregation and shows a genetic interaction with alpha- tubulin

1998 • 40 citations

Localization of motor-related proteins and associated complexes to active, but not inactive, centromeres

1998 • 38 citations

Specific Interaction between Human Kinetochore Protein CENP-C and a Nucleolar Transcriptional Regulator

1996 • 33 citations

A method that allows the assembly of kinetochore components onto chromosomes condensed in clarified Xenopus egg extracts

1997 • 30 citations

Gene Structure and Sequence Analysis of Mouse Centromere Proteins A and C

1998 • 23 citations

Cellular expression of human centromere protein C demonstrates a cyclic behavior with highest abundance in the G1 phase.

1996 • 17 citations

M33, a mammalian homologue of Drosophila Polycomb localises to euchromatin within interphase nuclei but is enriched within the centromeric heterochromatin of metaphase chromosomes

1997 • 17 citations

Dynamics of Cell Division

1999 • 10 citations

Mutations Affecting Chromatid Separation inDrosophila:ThefizzyMetaphase Arrest Persists inpimples fizzyandfizzy three rowsDouble Mutants

1997 • 6 citations

A moveable feast: the centromere-kinetochore complex in cell division

1998 • 4 citations

Recognition of mammalian centromeres by anti-dynein and anti-dynactin components

1998 • 3 citations