Mutations in the fission yeast silencing factors clr4 + and rik1 + disrupt the localisation of the chromo domain protein Swi6p and impair centromere function

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

[56] Molecular genetic analysis of fission yeast Schizosaccharomyces pombe

1991 • 3,691 citations

Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription

1990 • 1,343 citations

Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: A molecular model for the formation of heterochromatin in yeast

1995 • 778 citations

Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae

1991 • 700 citations

Definition of individual components within the cytoskeleton of Trypanosoma brucei by a library of monoclonal antibodies

1989 • 650 citations

Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1.

1994 • 547 citations

Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle.

1994 • 511 citations

Cell cycle-dependent specific positioning and clustering of centromeres and telomeres in fission yeast.

1993 • 506 citations

The use of cell division cycle mutants to investigate the control of microtubule distribution in the fission yeast Schizosaccharomyces pombe

1988 • 493 citations

Position effect variegation in Drosophila is associated with an altered chromatin structure.

1995 • 475 citations

Telomere-Led Premeiotic Chromosome Movement in Fission Yeast

1994 • 473 citations

Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation.

1995 • 447 citations

Microtubules

1984 • 405 citations

SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres

1993 • 392 citations

Position effect variegation at fission yeast centromeres

1994 • 332 citations

The Chromodomain Protein Swi6: A Key Component at Fission Yeast Centromeres

1995 • 300 citations

Position-effect variegation after 60 years

1990 • 286 citations

RAP1 and telomere structure regulate telomere position effects in Saccharomyces cerevisiae.

1993 • 283 citations

NDC10: a gene involved in chromosome segregation in Saccharomyces cerevisiae.

1993 • 264 citations

Functional analysis of the chromo domain of HP1.

1995 • 259 citations

A low copy number central sequence with strict symmetry and unusual chromatin structure in fission yeast centromere.

1992 • 247 citations

Position-effect variegation and the new biology of heterochromatin

1994 • 244 citations

The chromo shadow domain, a second chromo domain in heterochromatin-binding protein 1, HP1

1995 • 236 citations

Telomere-proximal DNA in Saccharomyces cerevisiae is refractory to methyltransferase activity in vivo.

1992 • 227 citations

Fission yeast minichromosome loss mutants mis cause lethal aneuploidy and replication abnormality.

1994 • 211 citations

Cold-sensitive and caffeine-supersensitive mutants of the Schizosaccharomyces pombe dis genes implicated in sister chromatid separation during mitosis.

1988 • 210 citations

Purification of yeast tubulin by self-assembly in vitro

1981 • 203 citations

Identification of essential components of the S. cerevisiae kinetochore

1993 • 198 citations

Localization of centromere function in a drosophila minichromosome

1995 • 186 citations

Antigenic variation in malaria

1995 • 184 citations

The carboxy termini of Sir4 and Rap1 affect Sir3 localization: evidence for a multicomponent complex required for yeast telomeric silencing.

1995 • 180 citations

Telomere-associated chromosome breakage in fission yeast results in variegated expression of adjacent genes.

1994 • 178 citations

Heterochromatin protein 1 is required for correct chromosome segregation in Drosophila embryos

1995 • 168 citations

Cold-sensitive nuclear division arrest mutants of the fission yeast Schizosaccharomyces pombe

1983 • 165 citations

Switching gene swi6, involved in repression of silent mating-type loci in fission yeast, encodes a homologue of chromatin-associated proteins from Drosophila and mammals

1994 • 163 citations

Structural and functional conservation of the human homolog of the Schizosaccharomyces pombe rad2 gene, which is required for chromosome segregation and recovery from DNA damage.

1994 • 154 citations

Two cell division cycle genes NDA2 and NDA3 of the fission yeast Schizosaccharomyces pombe control microtubular organization and sensitivity to anti-mitotic benzimidazole compounds

1983 • 150 citations

The centromeric K-type repeat and the central core are together sufficient to establish a functional Schizosaccharomyces pombe centromere.

1994 • 143 citations

Characterization of Schizosaccharomyces pombe minichromosome deletion derivatives and a functional allocation of their centromere.

1989 • 143 citations

Structural and functional homology between mammalian DNase IV and the 5'-nuclease domain of Escherichia coli DNA polymerase I.

1994 • 139 citations

Position effect variegation in Drosophila: Towards a genetics of chromatin assembly

1989 • 134 citations

Mutations in rik1, clr2, clr3 and clr4 genes asymmetrically derepress the silent mating-type loci in fission yeast.

1994 • 122 citations

A 125-base-pair CEN6 DNA fragment is sufficient for complete meiotic and mitotic centromere functions in Saccharomyces cerevisiae.

1989 • 120 citations

Centromere DNA mutations induce a mitotic delay in Saccharomyces cerevisiae.

1992 • 113 citations

A Conditional Lethal Mutant in the Fission Yeast 26 S Protease Subunit mts3+ Is Defective in Metaphase to Anaphase Transition

1996 • 110 citations

The clr1 locus regulates the expression of the cryptic mating-type loci of fission yeast.

1992 • 107 citations

Visualization of centromeric and nucleolar DNA in fission yeast by fluorescence in situ hybridization

1992 • 106 citations

Centromeres of the fission yeast Schizosaccharomyces pombe are highly variable genetic loci.

1993 • 93 citations

CEP3 encodes a centromere protein of Saccharomyces cerevisiae.

1995 • 80 citations

Directionality of fission yeast mating-type interconversion is controlled by the location of the donor loci.

1993 • 79 citations

Mutations in the protein phosphatase 1 gene at 87B can differentially affect suppression of position-effect variegation and mitosis in Drosophila melanogaster.

1993 • 75 citations

The switching gene swi6 affects recombination and gene expression in the mating-type region of Schizosaccharomyces pombe

1992 • 58 citations

LOCALIZATION OF THE GENETIC FACTORS RESPONSIBLE FOR THE KINETIC ACTIVITY OF X CHROMOSOMES OF DROSOPHILA MELANOGASTER

1958 • 48 citations

Unblocking of meiotic crossing-over between the silent mating-type cassettes of fission yeast, conditioned by the recessive, pleiotropic mutant rik1

1989 • 48 citations

The elusive centromere: sequence divergence and functional conservation

1995 • 39 citations

Somatic instability of a Drosophila chromosome.

1992 • 37 citations

Construction and characterization of centric circular and acentric linear chromosomes in fission yeast

1990 • 33 citations