Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation.

[56] Molecular genetic analysis of fission yeast Schizosaccharomyces pombe

1991 • 3,691 citations

Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription

1990 • 1,343 citations

A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

1993 • 858 citations

Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae

1991 • 700 citations

A position-effect assay for boundaries of higher order chromosomal domains

1991 • 616 citations

The Polycomb protein shares a homologous domain with a heterochromatin-associated protein of Drosophila.

1991 • 566 citations

Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila

1994 • 506 citations

Cell cycle-dependent specific positioning and clustering of centromeres and telomeres in fission yeast.

1993 • 506 citations

Yeast Origin Recognition Complex Functions in Transcription Silencing and DNA Replication

1993 • 435 citations

SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres

1993 • 392 citations

Position effect variegation at fission yeast centromeres

1994 • 332 citations

The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation.

1992 • 318 citations

Origin Recognition Complex (ORC) in Transcriptional Silencing and DNA Replication in S. cerevisiae

1993 • 314 citations

Silencers, silencing, and heritable transcriptional states

1992 • 296 citations

Visualization of centromere proteins CENP-B and CENP-C on a stable dicentric chromosome in cytological spreads

1989 • 293 citations

Position-effect variegation after 60 years

1990 • 286 citations

RAP1 and telomere structure regulate telomere position effects in Saccharomyces cerevisiae.

1993 • 283 citations

Localization of RAP1 and topoisomerase II in nuclei and meiotic chromosomes of yeast

1992 • 280 citations

A sequence motif found in aDrosophilaheterochromatin protein is conserved in animals and plants

1991 • 273 citations

Spatial organization of chromosomes in the salivary gland nuclei of Drosophila melanogaster.

1986 • 270 citations

A low copy number central sequence with strict symmetry and unusual chromatin structure in fission yeast centromere.

1992 • 247 citations

Position-effect variegation and the new biology of heterochromatin

1994 • 244 citations

CENP-B: a major human centromere protein located beneath the kinetochore.

1990 • 238 citations

Yeast origin recognition complex is involved in DNA replication and transcriptional silencing

1993 • 231 citations

Telomere-proximal DNA in Saccharomyces cerevisiae is refractory to methyltransferase activity in vivo.

1992 • 227 citations

A mammalian homologue of Drosophila heterochromatin protein 1 (HP1) is a component of constitutive heterochromatin

1994 • 196 citations

Chromosome walking shows a highly homologous repetitive sequence present in all the centromere regions of fission yeast

1986 • 188 citations

Active genes in budding yeast display enhanced in vivo accessibility to foreign DNA methylases: a novel in vivo probe for chromatin structure of yeast.

1992 • 188 citations

Integration of human α-satellite DNA into simian chromosomes: Centromere protein binding and disruption of normal chromosome segregation

1992 • 187 citations

Telomere-associated chromosome breakage in fission yeast results in variegated expression of adjacent genes.

1994 • 178 citations

Switching gene swi6, involved in repression of silent mating-type loci in fission yeast, encodes a homologue of chromatin-associated proteins from Drosophila and mammals

1994 • 163 citations

Molecular cloning of a human homologue of Drosophila heterochromatin protein HP1 using anti-centromere autoantibodies with anti-chromo specificity

1993 • 162 citations

Cell Cycle-Dependent Distribution of Telomeres, Centromeres, and Chromosome-Specific Subsatellite Domains in the Interphase Nucleus of Mouse Lymphocytes

1993 • 161 citations

Cell cycle dependent chromosomal movement in pre-mitotic human T-lymphocyte nuclei

1992 • 154 citations

Characterization of Schizosaccharomyces pombe minichromosome deletion derivatives and a functional allocation of their centromere.

1989 • 143 citations

A novel epigenetic effect can alter centromere function in fission yeast

1994 • 138 citations

Mammalian chromosome structure

1993 • 135 citations

Replicating plasmids in Schizosaccharomyces pombe: improvement of symmetric segregation by a new genetic element.

1986 • 135 citations

Position effect variegation in Drosophila: Towards a genetics of chromatin assembly

1989 • 134 citations

Three additional linkage groups that repress transcription and meiotic recombination in the mating-type region of Schizosaccharomyces pombe.

1994 • 123 citations

Mutations in rik1, clr2, clr3 and clr4 genes asymmetrically derepress the silent mating-type loci in fission yeast.

1994 • 122 citations

The chromatin structure of centromeres from fission yeast: differentiation of the central core that correlates with function.

1991 • 115 citations

Mechanisms of heritable gene repression during development of Drosophila

1993 • 113 citations

The clr1 locus regulates the expression of the cryptic mating-type loci of fission yeast.

1992 • 107 citations

Disruption of centromere assembly during interphase inhibits kinetochore morphogenesis and function in mitosis

1991 • 96 citations

Overlapping domains of the heterochromatin-associated protein HP1 mediate nuclear localization and heterochromatin binding.

1993 • 95 citations

De novo formation of several features of a centromere following introduction of a Y alphoid YAC into mammalian cells

1994 • 95 citations

Centromeres of the fission yeast Schizosaccharomyces pombe are highly variable genetic loci.

1993 • 93 citations

A reconsideration of the mechanism of position effect.

1994 • 86 citations

Directionality of fission yeast mating-type interconversion is controlled by the location of the donor loci.

1993 • 79 citations

Identification of DNA regions required for mitotic and meiotic functions within the centromere of Schizosaccharomyces pombe chromosome I.

1991 • 76 citations

The structure of the mammalian centromere

1991 • 75 citations

Mutations in the protein phosphatase 1 gene at 87B can differentially affect suppression of position-effect variegation and mitosis in Drosophila melanogaster.

1993 • 75 citations

Reversion of autonomously replicating sequence mutations in Saccharomyces cerevisiae: creation of a eucaryotic replication origin within procaryotic vector DNA.

1990 • 55 citations

Human autoimmune sera recognize a conserved 26 kD protein associated with mammalian heterochromatin that is homologous to heterochromatin protein 1 ofDrosophila

1994 • 54 citations

Structure of the fission yeast centromere cen3: Direct analysis of the reiterated inverted region

1991 • 54 citations

Structure and Function of Schizosaccharomyces pombe Centromeres

1993 • 53 citations

Unblocking of meiotic crossing-over between the silent mating-type cassettes of fission yeast, conditioned by the recessive, pleiotropic mutant rik1

1989 • 48 citations

Somatic instability of a Drosophila chromosome.

1992 • 37 citations

Construction and characterization of centric circular and acentric linear chromosomes in fission yeast

1990 • 33 citations

Modulation of tk expression in mouse pericentromeric heterochromatin.

1986 • 26 citations

[51] Manipulation of large minichromosomes in Schizosaccharomyces pombe with liposome-enhanced transformation

1992 • 5 citations