Oxidative Injury and Apoptosis of Dorsal Root Ganglion Neurons in Chronic Experimental Diabetic Neuropathy

The biochemistry of apoptosis

2000 • 7,314 citations

Oxidative damage and mitochondrial decay in aging.

1994 • 2,024 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

1980 • 1,609 citations

NONDROPLET ULTRASTRUCTURAL DEMONSTRATION OF CYTOCHROME OXIDASE ACTIVITY WITH A POLYMERIZING OSMIOPHILIC REAGENT, DIAMINOBENZIDINE (DAB)

1968 • 892 citations

Oxygen radicals and the nervous system

1985 • 822 citations

Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation

2001 • 609 citations

Quantitative immunohistochemical determination of 8-hydroxy-2'-deoxyguanosine by a monoclonal antibody N45.1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model.

1997 • 579 citations

Reactive oxygen species‐induced molecular damage and its application in pathology

1999 • 549 citations

Contributions of polyol pathway to oxidative stress in diabetic cataract

1999 • 517 citations

Neurons Undergo Apoptosis in Animal and Cell Culture Models of Diabetes

1999 • 410 citations

Lipoic Acid Improves Nerve Blood Flow, Reduces Oxidative Stress, and Improves Distal Nerve Conduction in Experimental Diabetic Neuropathy

1995 • 377 citations

Oxidative Stress and Programmed Cell Death in Diabetic Neuropathy

2002 • 357 citations

Pivotal Role of Mitochondrial Calcium Uptake in Neural Cell Apoptosis and Necrosis

1999 • 352 citations

Endogenous levels of nerve growth factor (NGF) are altered in experimental diabetes mellitus: A possible role for NGF in the pathogenesis of diabetic neuropathy

1990 • 316 citations

Complications: Neuropathy, Pathogenetic Considerations

1992 • 301 citations

New biomarker evidence of oxidative DNA damage in patients with non‐insulin‐dependent diabetes mellitus

1997 • 263 citations

Diabetic peripheral neuropathy: evidence for apoptosis and associated mitochondrial dysfunction.

2000 • 256 citations

Glucose-induced oxidative stress and programmed cell death in diabetic neuropathy

1999 • 239 citations

Topographical differences in the vascular permeability of the peripheral nervous system

1968 • 225 citations

Nerve Blood Flow and Oxygen Delivery In Normal, Diabetic, and Ischemic Neuropathy

1989 • 212 citations

Oxidative DNA damage in diabetes mellitus: its association with diabetic complications

1999 • 207 citations

Nerve Conduction Changes in Experimental Diabetes*

1964 • 195 citations

Advanced products of nonenzymatic glycosylation and the pathogenesis of diabetic vascular disease

1988 • 190 citations

Oxygen Free Radical Effects in Sciatic Nerve in Experimental Diabetes

1991 • 161 citations

4-Hydroxynonenal Induces Apoptosis via Caspase-3 Activation and CytochromecRelease

2001 • 143 citations

Protein kinase C effects on nerve function, perfusion, Na + ,K + -ATPase activity and glutathione content in diabetic rats

1999 • 130 citations

A method for unbiased and efficient estimation of number and mean volume of specified neuron subtypes in rat dorsal root ganglion

1993 • 125 citations

Morphometric Alteration of Rat Myelinated Fibers with Aging

1989 • 116 citations

Morphometry of Dorsal Root Ganglion in Chronic Experimental Diabetic Neuropathy

2002 • 115 citations

New insights into the pathogenesis of diabetic neuropathy

1999 • 114 citations

Neuropathology and blood flow of nerve, spinal roots and dorsal root ganglia in longstanding diabetic rats

1997 • 101 citations

Ischemic conduction failure and energy metabolism in experimental diabetic neuropathy

1985 • 99 citations

Antioxidants in Diabetes Management

2000 • 91 citations

Effect of α-tocopherol deficiency on indices of oxidative stress in normal and diabetic peripheral nerve

1994 • 87 citations

Sorbitol, inositol and nerve conduction in diabetes

1983 • 68 citations

Oxygen free radical effects in sciatic nerve in experimental diabetes

1991 • 61 citations

Oxygen toxicity in the nervous tissue: Comparison of the antioxidant defense of rat brain and sciatic nerve

1991 • 53 citations

The Effect of Age on Mitochondrial Ultrastructure and Enzymes

1975 • 46 citations

Decreased glutathione peroxidase activity in sciatic nerve of alloxan-induced diabetic mice and its correlation with blood glucose levels

1993 • 45 citations

Severe radicular pathology in rats with longstanding diabetes

1994 • 44 citations

Effects of evening primrose oil treatment on sciatic nerve blood flow and endoneurial oxygen tension in streptozotocin-diabetic rats

1994 • 43 citations

Effects of endothelin receptor antagonism with bosentan on peripheral nerve function in experimental diabetes

1995 • 37 citations

Localization of survival motor neuron protein in human apoptotic-like and regenerating muscle fibers, and neuromuscular junctions

1999 • 34 citations

Improvement of endoneurial lipid abnormalities in experimental diabetic neuropathy by oxygen modification

1986 • 25 citations

Antioxidant and glutathione-related enzymatic activities in rat sciatic nerve

1990 • 17 citations

Chronic constriction model of rat sciatic nerve: nerve blood flow, morphologic and biochemical alterations

1996 • 17 citations