Functional Analysis of Chimeric Genes Obtained by Exchanging Homologous Domains of the Mouse mdr1 and mdr2 Genes

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1984 • 4,899 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.

1979 • 1,339 citations

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

Human GM-CSF: Molecular Cloning of the Complementary DNA and Purification of the Natural and Recombinant Proteins

1985 • 1,253 citations

Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport

1990 • 1,149 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

1985 • 843 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

The multidrug transporter, a double-edged sword.

1988 • 763 citations

Active outward transport of daunomycin in resistant ehrlich ascites tumor cells

1973 • 729 citations

Reduced permeability in CHO cells as a mechanism of resistance to colchicine

1974 • 695 citations

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

1986 • 688 citations

The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein

1989 • 604 citations

Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum

1990 • 594 citations

Nucleotide sequence of an Escherichia coli chromosomal hemolysin

1985 • 572 citations

Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum

1989 • 570 citations

ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.

1988 • 480 citations

Saccharomyces cerevisiae STE6 gene product: a novel pathway for protein export in eukaryotic cells.

1989 • 443 citations

Secretion of cyclolysin, the calmodulin-sensitive adenylate cyclase-haemolysin bifunctional protein of Bordetella pertussis.

1988 • 436 citations

An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene

1988 • 430 citations

Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase.

1988 • 340 citations

The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles

1989 • 329 citations

Sequence of mdr3 cDNA encoding a human P-glycoprotein

1988 • 292 citations

Vinblastine photoaffinity labeling of a high molecular weight surface membrane glycoprotein specific for multidrug-resistant cells.

1986 • 290 citations

The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus.

1988 • 270 citations

Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells

1989 • 241 citations

Cloning, nucleotide sequence, and characterization of genes encoding the secretion function of the Pasteurella haemolytica leukotoxin determinant

1989 • 239 citations

ATP‐binding properties of P glycoprotein from multidrug‐resistant KB cells

1987 • 207 citations

Protein kinases 1988: a current perspective

1988 • 201 citations

Protein kinase C phosphorylates P-glycoprotein in multidrug resistant human KB carcinoma cells.

1990 • 200 citations

Two different regions of Phosphoglycoprotein are photoaffinity-labeled by azidopine

1989 • 196 citations

Transepithelial Transport of Drugs by the Multidrug Transporter in Cultured Madin-Darby Canine Kidney Cell Epithelia

1989 • 191 citations

ATP/Mg2+-dependent binding of vincristine to the plasma membrane of multidrug-resistant K562 cells.

1988 • 143 citations

Cytoplasmic Orientation and Two-domain Structure of the Multidrug Transporter, P-glycoprotein, Demonstrated with Sequence-specific Antibodies

1989 • 135 citations

Phosphorylation of the multidrug resistance associated glycoprotein

1987 • 131 citations

Multidrug resistance gene expression is controlled by steroid hormones in the secretory epithelium of the uterus

1990 • 103 citations

Characterization of cell lines showing growth control isolated from both the wild type and a leucyl‐tRNA synthetase mutant of chinese hamster ovary cells

1979 • 100 citations

Steroid hormones inhibit binding of alkaloid to multidrug resistance related P-glycoprotein

1989 • 74 citations

Two Members of the Mouse mdr Gene Family Confer Multidrug Resistance with Overlapping but Distinct Drug Specificities

1990 • 69 citations

Photoaffinity labeling of P-glycoprotein in multidrug resistant cells with photoactive analogs of colchicine

1989 • 65 citations

Discrete Mutations Introduced in the Predicted Nucleotide-Binding Sites of the mdr1 Gene Abolish Its Ability To Confer Multidrug Resistance

1989 • 57 citations

Structure and Expression of the Human MDR (P-Glycoprotein) Gene Family

1989 • 54 citations

Cloning and Characterization of a Second Member of the Mouse mdr Gene Family

1988 • 45 citations

Identification of Members of the P-Glycoprotein Multigene Family

1989 • 41 citations

Physical Mapping, Amplification, and Overexpression of the Mouse mdr Gene Family in Multidrug-Resistant Cells

1990 • 26 citations

Structural Analysis of the Mouse mdr1a (P-Glycoprotein) Promoter Reveals the Basis for Differential Transcript Heterogeneity in Multidrug-Resistant J774.2 Cells

1990 • 19 citations