Cytoplasmic accumulation of cdc25B phosphatase in mitosis triggers centrosomal microtubule nucleation in HeLa cells

SRα Promoter: an Efficient and Versatile Mammalian cDNA Expression System Composed of the Simian Virus 40 Early Promoter and the R-U5 Segment of Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat

1988 • 1,351 citations

Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

1987 • 1,153 citations

Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control

1993 • 1,096 citations

Site-directed mutagenesis of virtually any plasmid by eliminating a unique site

1992 • 1,089 citations

cdc25+ functions as an inducer in the mitotic control of fission yeast

1986 • 973 citations

Solubilization and Purification of Enzymatically Active Glutathione S-Transferase (pGEX) Fusion Proteins

1993 • 891 citations

cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2

1991 • 870 citations

Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport.

1991 • 858 citations

In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase

1990 • 783 citations

Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast

1981 • 740 citations

The cdc25 protein contains an intrinsic phosphatase activity

1991 • 595 citations

Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein

1991 • 579 citations

Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: Evidence for multiple roles of mitotic cyclins

1991 • 509 citations

Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates.

1991 • 502 citations

Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transition.

1994 • 485 citations

Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated cdc2 kinase

1993 • 456 citations

Regulation of microtubule dynamics by cdc2 protein kinase in cell-free extracts of Xenopus eggs

1990 • 446 citations

Cdc25A is a novel phosphatase functioning early in the cell cycle.

1994 • 442 citations

Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites.

1991 • 439 citations

The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells

1989 • 439 citations

Control of microtubule dynamics and length by cyclin A- and cyclin B-dependent kinases in Xenopus egg extracts.

1992 • 419 citations

p34cdc2 is located in both nucleus and cytoplasm; part is centrosomally associated at G2/M and enters vesicles at anaphase.

1989 • 376 citations

Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2.

1990 • 352 citations

Fission yeast p107wee1 mitotic inhibitor is a tyrosine/serine kinase

1991 • 344 citations

Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates.

1991 • 318 citations

Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells

1992 • 298 citations

Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15.

1993 • 247 citations

p55CDC25 is a nuclear protein required for the initiation of mitosis in human cells.

1991 • 235 citations

Regulation of mitosis by cyclic accumulation of p80cdc25 mitotic inducer in fission yeast

1990 • 221 citations

Cyclin promotes the tyrosine phosphorylation of p34cdc2 in a wee1+ dependent manner.

1991 • 218 citations

cdc25+ encodes a protein phosphatase that dephosphorylates p34cdc2.

1992 • 211 citations

Cytoplasmic accumulation of cyclin B1 in human cells: Association with a detergent-resistant compartment and with the centrosome

1992 • 211 citations

Distinct nuclear and spindle pole body populations of cyclin–cdc2 in fission yeast

1990 • 198 citations

Mode of centriole duplication and distribution.

1990 • 197 citations

An additional homolog of the fission yeast cdc25+ gene occurs in humans and is highly expressed in some cancer cells.

1991 • 196 citations

Microtubule-nucleating activity of centrosomes in Chinese hamster ovary cells is independent of the centriole cycle but coupled to the mitotic cycle.

1981 • 191 citations

Microinjection of p34cdc2 kinase induces marked changes in cell shape, cytoskeletal organization, and chromatin structure in mammalian fibroblasts

1990 • 153 citations

Cell division in higher plants: a cdc2 gene, its 34-kDa product, and histone H1 kinase activity in pea.

1990 • 152 citations

Mitosis-specific phosphorylation of nucleolin by p34cdc2 protein kinase.

1990 • 151 citations

A flow-cytometric method for the separation and quantitation of normal and apoptotic thymocytes

1992 • 132 citations

Cell cycle regulation of the p34cdc2 inhibitory kinases.

1994 • 120 citations

In vitro microtubule-nucleating activity of spindle pole bodies in fission yeast Schizosaccharomyces pombe: cell cycle-dependent activation in xenopus cell-free extracts

1992 • 89 citations

Fission yeast CDC25 is a cell-cycle regulated protein

1990 • 72 citations

Chromosome condensation caused by loss of RCC1 function requires the cdc25C protein that is located in the cytoplasm.

1992 • 71 citations

Identification of a transitional preapoptotic population of thymocytes

1993 • 66 citations

Requirement for p34cdc2 kinase is restricted to mitosis in the mammalian cdc2 mutant FT210

1992 • 65 citations

Microtubule nucleating activity of centrosomes in cell-free extracts from Xenopus eggs: involvement of phosphorylation and accumulation of pericentriolar material

1993 • 64 citations

Cdc25 regulates the phosphorylation and activity of the Xenopus cdk2 protein kinase complex.

1992 • 63 citations

Identification of a transitional preapoptotic population of thymocytes.

1993 • 52 citations

Purification and characterization of growth-associated H1 histone kinase from Novikoff hepatoma cells.

1990 • 35 citations