Endogenous c-N-Ras Provides a Steady-state Anti-apoptotic Signal

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

1997 • 2,747 citations

QUANTITATIVE STUDIES OF THE GROWTH OF MOUSE EMBRYO CELLS IN CULTURE AND THEIR DEVELOPMENT INTO ESTABLISHED LINES

1963 • 2,742 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

BCL-2 FAMILY: Regulators of Cell Death

1998 • 1,687 citations

Molecular thanatopsis: a discourse on the BCL2 family and cell death

1996 • 1,412 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

Signal transduction via the MAP kinases: proceed at your own RSK.

1993 • 1,262 citations

Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase

1996 • 1,253 citations

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

1997 • 1,190 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

Increasing complexity of Ras signaling

1998 • 1,069 citations

Bcl-2 family proteins

1998 • 1,055 citations

Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase

1993 • 987 citations

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1992 • 980 citations

Stimulation of p21ras upon T-cell activation

1990 • 882 citations

Phosphorylation and Inactivation of BAD by Mitochondria-Anchored Protein Kinase A

1999 • 635 citations

Complex formation between RAS and RAF and other protein kinases.

1993 • 633 citations

Ras signalling and apoptosis

1998 • 559 citations

K-ras is an essential gene in the mouse with partial functional overlap with N-ras

1997 • 537 citations

Multiple components in an epidermal growth factor-stimulated protein kinase cascade

1991 • 502 citations

Ras Isoforms Vary in Their Ability to Activate Raf-1 and Phosphoinositide 3-Kinase

1998 • 475 citations

Extracellular signals and reversible protein phosphorylation: What to Mek of it all

1993 • 426 citations

Regulation of Bad Phosphorylation and Association with Bcl-xL by the MAPK/Erk Kinase

1999 • 385 citations

The Kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136

1998 • 360 citations

The structure of Ras protein: a model for a universal molecular switch

1991 • 310 citations

Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator.

1994 • 281 citations

Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap.

1994 • 270 citations

Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway

1997 • 268 citations

ralGDS family members interact with the effector loop of ras p21.

1994 • 260 citations

Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway

1999 • 258 citations

RAS pathways to cell cycle control and cell transformation

1998 • 247 citations

The murine N-ras gene is not essential for growth and development.

1995 • 236 citations

Signal transduction pathways that regulate cell survival and cell death

1998 • 187 citations

Direct Interaction between Ras and the Kinase Domain of Mitogen-activated Protein Kinase Kinase Kinase (MEKK1)

1995 • 177 citations

Suppression of Ras-Induced Apoptosis by the Rac GTPase

1999 • 177 citations

Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas

1999 • 159 citations

Molecular switch in signal transduction: Reaction paths of the conformational changes in ras p21

1997 • 157 citations

Tumor Necrosis Factor Induces Phosphorylation and Translocation of BAD through a Phosphatidylinositide-3-OH Kinase-dependent Pathway

1999 • 141 citations

The mitogen-activated protein kinase cascade is activated by B-Raf in response to nerve growth factor through interaction with p21ras.

1994 • 141 citations

RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein.

1996 • 121 citations

Signal transduction pathways from insulin receptors to Ras. Analysis by mutant insulin receptors.

1994 • 116 citations

Mutant N-ras Induces Myeloproliferative Disorders and Apoptosis in Bone Marrow Repopulated Mice

1999 • 110 citations

Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types.

1993 • 100 citations

Phosphatidylinositol 3’ kinase: one of the effectors of Ras

1996 • 82 citations

Two Distinct Interleukin-3-Mediated Signal Pathways, Ras-NFIL3 (E4BP4) and Bcl-x_L, Regulate the Survival of Murine Pro-B Lymphocytes

1999 • 79 citations

Ras signaling in tumor necrosis factor-induced apoptosis.

1996 • 77 citations

Ha-ras and N-ras regulate MAPK activity by distinct mechanisms in vivo

1998 • 73 citations

Association of MEK1 with p21ras.GMPPNP is dependent on B-Raf.

1994 • 73 citations

Oncogenic ras Causes Resistance to the Growth Inhibitor Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) in Breast Cancer Cells

1999 • 67 citations

Activated Ha-ras Induces Apoptosis by Association with Phosphorylated Bcl-2 in a Mitogen-activated Protein Kinase-independent Manner

1999 • 37 citations

Selective Activation of Ha-rasval12Oncogene Increases Susceptibility of NIH/3T3 Cells to TNF-α

1999 • 20 citations

Differences in the interaction of p21c-Ha-ras-GMP-PNP with full-length neurofibromin and GTPase-activating protein.

1993 • 18 citations

Role of the Raf/Mitogen-activated Protein Kinase Pathway in p21 Desensitization

1996 • 18 citations