Vitamin D3-induced Apoptosis of Murine Squamous Cell Carcinoma Cells

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human

1999 • 2,692 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3.

1981 • 1,025 citations

Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937.

1996 • 922 citations

The Role of c-Jun N-terminal Kinase (JNK) in Apoptosis Induced by Ultraviolet C and γ Radiation

1996 • 881 citations

Membrane and Morphological Changes in Apoptotic Cells Regulated by Caspase-Mediated Activation of PAK2

1997 • 742 citations

Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53.

1994 • 514 citations

The Regulation of Anoikis: MEKK-1 Activation Requires Cleavage by Caspases

1997 • 507 citations

Caspase-dependent Cleavage of Signaling Proteins during Apoptosis

1998 • 420 citations

Bax cleavage is mediated by calpain during drug-induced apoptosis

1998 • 330 citations

Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3

1997 • 330 citations

Suppression of in vivo growth of human cancer solid tumor xenografts by 1,25-dihydroxyvitamin D3.

1987 • 312 citations

B-Raf Inhibits Programmed Cell Death Downstream of Cytochrome c Release from Mitochondria by Activating the MEK/Erk Pathway

1999 • 311 citations

Apoptosis is induced by the active metabolite of vitamin D3 and its analogue EB1089 in colorectal adenoma and carcinoma cells: possible implications for prevention and therapy.

2000 • 308 citations

MEK Kinase 1, a Substrate for DEVD-Directed Caspases, Is Involved in Genotoxin-Induced Apoptosis

1998 • 236 citations

Vitamin d inhibition of prostate adenocarcinoma growth and metastasis in the dunning rat prostate model system

1997 • 225 citations

Antiproliferative Effect of 1α,25-Dihydroxyvitamin D3 in Human Prostate Cancer Cell Line LNCaP Involves Reduction of Cyclin-Dependent Kinase 2 Activity and Persistent G1 Accumulation

1998 • 225 citations

Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis.

2000 • 216 citations

Fibroblast Growth Factor-2 Suppression of Tumor Necrosis Factor α-Mediated Apoptosis Requires Ras and the Activation of Mitogen-activated Protein Kinase

1996 • 213 citations

Apoptosis induced by vitamin D compounds in breast cancer cells is inhibited by Bcl-2 but does not involve known caspases or p53.

1999 • 213 citations

Caspase-dependent Activation of Calpain during Drug-induced Apoptosis

1999 • 206 citations

Calcitriol-Induced Apoptosis in LNCaP Cells Is Blocked By Overexpression of Bcl-21

2000 • 201 citations

TREATMENT OF EARLY RECURRENT PROSTATE CANCER WITH 1,25-DIHYDROXYVITAMIN D3 (CALCITRIOL)

1998 • 200 citations

Caspase-3 is essential for procaspase-9 processing and cisplatin-induced apoptosis of MCF-7 breast cancer cells.

2000 • 193 citations

Inhibition of proliferation of prostate cancer cells by a 19-nor-hexafluoride vitamin D3 analogue involves the induction of p21waf1, p27kip1 and E-cadherin

1997 • 189 citations

Suppression of transforming growth factor-β-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway

1998 • 187 citations

1,25-Dihydroxyvitamin D3 induces morphological and biochemical markers of apoptosis in MCF-7 breast cancer cells

1996 • 183 citations

The p42/p44 MAP Kinase Pathway Prevents Apoptosis Induced by Anchorage and Serum Removal

2000 • 179 citations

Comparative effects of 1,25(OH)2D3 and EB1089 on cell cycle kinetics and apoptosis in MCF-7 breast cancer cells

1997 • 164 citations

Anti-apoptotic versus pro-apoptotic signal transduction: Checkpoints and stop signs along the road to death

1998 • 161 citations

1,25-Dihydroxycholecalciferol (1,25-D3) inhibits the growth of squamous cell carcinoma and down-modulates p21(Waf1/Cip1) in vitro and in vivo.

1999 • 157 citations

Fas Induces Cytoplasmic Apoptotic Responses and Activation of the MKK7-JNK/SAPK and MKK6-p38 Pathways Independent of CPP32-like Proteases

1997 • 154 citations

Apoptotic Regression of MCF-7 Xenografts in Nude Mice Treated with the Vitamin D₃Analog, EB1089¹

1998 • 151 citations

Induction of apoptosis in breast cancer cells in response to vitamin D and antiestrogens

1994 • 150 citations

1,25-Dihydroxyvitamin D3 and all-trans-retinoic acid sensitize breast cancer cells to chemotherapy-induced cell death.

2000 • 149 citations

14-3-3 Proteins Interact with Specific MEK Kinases

1998 • 146 citations

Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain.

1996 • 134 citations

Two novel 14-Epi-analogues of 1,25-dihydroxyvitamin D3 inhibit the growth of human breast cancer cells in vitro and in vivo.

2000 • 130 citations

Fas-induced proteolytic activation and intracellular redistribution of the stress-signaling kinase MEKK1

1998 • 122 citations

Potentiation of cisplatin antitumor activity using a vitamin D analogue in a murine squamous cell carcinoma model system.

1997 • 122 citations

Lack of Correlation between Activation of Jun–NH2-terminal Kinase and Induction of Apoptosis after Detachment of Epithelial Cells

1997 • 118 citations

Vitamin D analogues up-regulate p21 and p27 during growth inhibition of pancreatic cancer cell lines

1997 • 117 citations

1,25-Dihydroxyvitamin D3 inhibitory effect on the growth of two human breast cancer cell lines (MCF-7, BT-20)

1986 • 116 citations

Lack of c‐Jun activity increases survival to cisplatin

1999 • 95 citations

A calcitriol analogue, EB1089, inhibits the growth of LNCaP tumors in nude mice.

2000 • 95 citations

The roles of signaling by the p42/p44 mitogen-activated protein (MAP) kinase pathway; a potential route to radio- and chemo-sensitization of tumor cells resulting in the induction of apoptosis and loss of clonogenicity

1998 • 94 citations

EB1089, a synthetic analogue of vitamin D, induces apoptosis in breast cancer cells in vivo and in vitro

1998 • 90 citations

Differential apoptotic response of human melanoma cells to 1α,25-dihydroxyvitamin D3 and its analogues

1998 • 87 citations

Vitamin D analogues suppress IGF-I signalling and promote apoptosis in breast cancer cells

1999 • 84 citations

EB 1089, a novel vitamin D Analog with strong antiproliferative and differentiation-inducing effects on target cells

1997 • 77 citations

A role for JNK/SAPK in proliferation, but not apoptosis, of IL-3-dependent cells

1997 • 73 citations

Potentiation of apoptosis by low dose stress stimuli in cells expressing activated MEK kinase 1

1997 • 71 citations

Regulation of the activity of MEK kinase 1 (MEKK1) by autophosphorylation within the kinase activation domain

1997 • 71 citations

Effects of vitamin D3 on proliferation of cancer cells in vitro

1997 • 70 citations

Identification of Two Essential Phosphorylated Threonine Residues In the Catalytic Domain of Mekk1

1997 • 67 citations

The Vitamin D 3 Analog EB 1089 Enhances the Response of Human Breast Tumor Cells to Radiation

1999 • 65 citations

Combined effects of 1,25-dihydroxyvitamin D3 and platinum drugs on the growth of MCF-7 cells.

1991 • 60 citations

Differential Effects of 1,25-Dihydroxyvitamin D3 and Tetradecanoylphorbol Acetate on Cell Cycle and Apoptosis of MCF-7 Cells and a Vitamin D3-Resistant Variant*

1997 • 55 citations

Potentiation by vitamin D analogs of TNFα and ceramide-induced apoptosis in MCF-7 cells is associated with activation of cytosolic phospholipase A2

1999 • 45 citations

Novel 19-nor-hexafluoride vitamin D3 analog (Ro 25-6760) inhibits human colon cancer in vitro via apoptosis.

1999 • 38 citations

Cisplatin-resistance involves the defective processing of MEKK1 in human ovarian adenocarcinoma 2008/C13 cells.

2000 • 37 citations

Inhibition of insulin-like growth factor I receptor signaling by the vitamin D analogue EB1089 in MCF-7 breast cancer cells: A role for insulin-like growth factor binding proteins.

1999 • 31 citations

Biological Activity In Vitro of Side-Chain Modified Analogues of Calcitriol

2000 • 30 citations

Vitamin D and Prostate Cancer

1999 • 28 citations

The Role of Vitamin D3 and Antiestrogens in Modulating Apoptosis of Breast Cancer Cells and Tumors

1998 • 28 citations

Synthetic analogs of vitamin D3 have inhibitory effects on breast cancer cell lines.

1998 • 8 citations

A Novel Class of Aromatic Vitamin D Analogs

2000 • 3 citations

Deleted Work

1955 • 0 citations