Activation of the p42 Mitogen-activated Protein Kinase Pathway Inhibits Cdc2 Activation and Entry into M-Phase in CyclingXenopusEgg Extracts

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Antibodies, a laboratory manual

1989 • 12,929 citations

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes

1971 • 1,553 citations

Mitotic and G ₂ Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216

1997 • 1,332 citations

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

1997 • 1,285 citations

Cyclin synthesis drives the early embryonic cell cycle

1989 • 1,223 citations

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

1993 • 1,169 citations

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

1989 • 1,114 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Chapter 30 Cell Cycle Extracts

1991 • 953 citations

Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis.

1993 • 675 citations

The c-mos proto-oncogene product is a cytostatic factor responsible for meiotic arrest in vertebrate eggs

1989 • 654 citations

Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast

1995 • 578 citations

Extracellular signal-regulated kinases: ERKs in progress.

1991 • 519 citations

Purification and Molecular Cloning of Plx1, a Cdc25-Regulatory Kinase from Xenopus Egg Extracts

1996 • 506 citations

The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system

1991 • 504 citations

Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro.

1993 • 503 citations

Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes

1991 • 493 citations

Regulation of the cdc25 protein during the cell cycle in Xenopus extracts

1992 • 430 citations

Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro.

1993 • 420 citations

Cdc2 regulatory factors

1994 • 414 citations

A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts

1994 • 402 citations

Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation

1997 • 392 citations

Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies.

1991 • 392 citations

Cell cycle tyrosine phosphorylation of p34cdc2 and a microtubule-associated protein kinase homolog in Xenopus oocytes and eggs.

1991 • 352 citations

Cell cycle regulation of a Xenopus Wee1-like kinase.

1995 • 316 citations

Cell cycle extracts.

1991 • 304 citations

The c-mos proto-oncogene protein kinase turns on and maintains the activity of MAP kinase, but not MPF, in cell-free extracts of Xenopus oocytes and eggs.

1993 • 297 citations

Oncogenes, Growth Factors, and Signal Transduction

1989 • 296 citations

Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity.

1992 • 294 citations

Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase.

1993 • 291 citations

Structure, expression, and regulation of protein kinases involved in the phosphorylation of ribosomal protein S6.

1991 • 265 citations

Induction of metaphase arrest in cleaving Xenopus embryos by MAP kinase

1993 • 264 citations

Meiotic initiation by the mos protein in Xenopus

1992 • 253 citations

Meiotic metaphase arrest in animal oocytes: its mechanisms and biological significance

1996 • 212 citations

Both cyclin A delta 60 and B delta 97 are stable and arrest cells in M-phase, but only cyclin B delta 97 turns on cyclin destruction.

1991 • 196 citations

Mos induces the in vitro activation of mitogen-activated protein kinases in lysates of frog oocytes and mammalian somatic cells.

1993 • 168 citations

Activation of p42 MAP kinase and the release of oocytes from cell cycle arrest.

1992 • 163 citations

Induction of Xenopus Oocyte Meiotic Maturation by MAP Kinase

1995 • 154 citations

A distinct vesicle population targets membranes and pore complexes to the nuclear envelope in Xenopus eggs.

1991 • 149 citations

MAP kinase and the activation of quiescent cells

1993 • 140 citations

Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes.

1992 • 134 citations

The spindle-assembly checkpoint: aiming for a perfect mitosis, every time

1996 • 119 citations

MAP Kinase Is Required for the Spindle Assembly Checkpoint but Is Dispensable for the Normal M Phase Entry and Exit in Xenopus Egg Cell Cycle Extracts

1997 • 102 citations

In vivo Phosphorylation and Activation of Ribosomal Protein S6 Kinases during Xenopus Oocyte Maturation

1989 • 102 citations

Activation of mitogen-activated protein kinase and its activator by ras in intact cells and in a cell-free system.

1992 • 101 citations

cdc25 is one of the MPM-2 antigens involved in the activation of maturation-promoting factor.

1994 • 100 citations

A Role for Mitogen-activated Protein Kinase in the Spindle Assembly Checkpoint in XTC Cells

1997 • 100 citations

MAP kinase links the fertilization signal transduction pathway to the G1/S-phase transition in starfish eggs

1997 • 89 citations

Phosphorylation of Xenopus cyclins B1 and B2 is not required for cell cycle transitions.

1991 • 88 citations

Mos Stimulates MAP Kinase in Xenopus Oocytes and Activates a MAP Kinase Kinase In Vitro

1993 • 82 citations

Cell Cycle Tyrosine Phosphorylation of p34^cdc2 and a Microtubule- Associated Protein Kinase Homolog in Xenopus Oocytes and Eggs

1991 • 79 citations

The ras Oncoprotein and M-Phase Activity

1991 • 74 citations

Stabilization and enhancement of primary cytostatic factor (CSF) by ATP and NaF in amphibian egg cytosols

1988 • 52 citations

Mitotic arrest caused by the amino terminus of Xenopus cyclin B2.

1993 • 48 citations

Raf-1 Is Activated during Mitosis

1995 • 47 citations

Activation of the Xenopus oocyte mitogen-activated protein kinase pathway by Mos is independent of Raf.

1996 • 34 citations

Cell cycle-regulated degradation of Xenopus cyclin B2 requires binding to p34cdc2.

1994 • 31 citations

RAS Signalling Is Abnormal in a c-raf1 MEK1 Double Mutant

1995 • 30 citations

Phosphorylation of Xenopus Cyclins B1 and B2 Is Not Required for Cell Cycle Transitions

1991 • 29 citations

Role of cdc25-C phosphatase in the immediate G2 delay induced by the exogenous factors epidermal growth factor and phorbolester

1996 • 24 citations

Activation of Mil/Raf protein kinases in mitotic cells.

1996 • 20 citations

[30] Assay of MEK kinases

1995 • 18 citations

Mitosis-specific monoclonal antibodies block cleavage in amphibian embryos.

1989 • 18 citations

Mitotic Arrest Caused by the Amino Terminus of Xenopus Cyclin B2

1993 • 11 citations