T-cell Responses to Myelin Antigens in Multiple Sclerosis; Relevance of the Predominant Autoimmune Reactivity to Myelin Oligodendrocyte Glycoprotein

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

The expanding universe of T-cell subsets: Th1, Th2 and more

1996 • 3,710 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Lymphokine Production by Human T Cells in Disease States

1994 • 1,351 citations

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

1988 • 940 citations

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1990 • 906 citations

Dominance and Crypticity of T Cell Antigenic Determinants

1993 • 838 citations

Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma.

1993 • 837 citations

Association between Tumor Necrosis Factor-α and Disease Progression in Patients with Multiple Sclerosis

1991 • 794 citations

Tumor necrosis factor identified in multiple sclerosis brain.

1989 • 793 citations

Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions.

1991 • 735 citations

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain.

1992 • 726 citations

Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones.

1992 • 697 citations

Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery.

1992 • 627 citations

A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H‐2^b mice: Fine specificity and T cell receptor Vβ expression of encephalitogenic T cells

1995 • 600 citations

Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy

1988 • 555 citations

Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis.

1994 • 539 citations

Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones.

1988 • 509 citations

Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients.

1996 • 487 citations

Myelin: Biology and Chemistry

1992 • 436 citations

ENCEPHALOMYELITIS ACCOMPANIED BY MYELIN DESTRUCTION EXPERIMENTALLY PRODUCED IN MONKEYS

1935 • 433 citations

Biology of disease. Analysis of autoimmune demyelination: its impact upon multiple sclerosis.

1984 • 424 citations

The small heat-shock protein αB-crystallin as candidate autoantigen in multiple sclerosis

1995 • 393 citations

Differential Ultrastructural Localization of Myelin Basic Protein, Myelin/Oligodendroglial Glycoprotein, and 2′,3′‐Cyclic Nucleotide 3′‐Phosphodiesterase in the CNS of Adult Rats

1989 • 388 citations

Identification of epitopes of myelin oligodendrocyte glycoprotein for the induction of experimental allergic encephalomyelitis in SJL and Biozzi AB/H mice.

1994 • 384 citations

A monoclonal antibody against a myelin oligodendrocyte glycoprotein induces relapses and demyelination in central nervous system autoimmune disease.

1987 • 368 citations

Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma.

1990 • 363 citations

Cytokine levels in the cerebrospinal fluid and serum of patients with multiple sclerosis

1991 • 330 citations

Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar V alpha and V beta chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different.

1989 • 321 citations

Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein.

1993 • 319 citations

A novel myelin-associated glycoprotein defined by a mouse monoclonal antibody

1984 • 318 citations

T and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis.

1991 • 314 citations

Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors.

1990 • 307 citations

Colocalization of lymphocytes bearing gamma delta T-cell receptor and heat shock protein hsp65+ oligodendrocytes in multiple sclerosis.

1991 • 285 citations

The demyelinating potential of antibodies to myelin oligodendrocyte glycoprotein is related to their ability to fix complement

1991 • 284 citations

Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions.

1992 • 280 citations

Cytokine accumulations in CSF of multiple sclerosis patients

1990 • 270 citations

T cells specific for the myelin oligodendrocyte glycoprotein mediate an unusual autoimmune inflammatory response in the central nervous system

1993 • 265 citations

Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls

1991 • 258 citations

Myelin/oligodendrocyte glycoprotein is a unique member of the immunoglobulin superfamily

1992 • 240 citations

Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide.

1994 • 237 citations

Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex.

1993 • 221 citations

Profiles of lymphokine activities and helper function for IgE in human T cell clones

1988 • 204 citations

Restricted T-cell receptor V beta gene usage by myelin basic protein-specific T-cell clones in multiple sclerosis: predominant genes vary in individuals.

1991 • 193 citations

Experimental autoimmune encephalomyelitis: the antigen specificity of T lymphocytes determines the topography of lesions in the central and peripheral nervous system.

1997 • 190 citations

Experimental autoimmune panencephalitis and uveoretinitis transferred to the Lewis rat by T lymphocytes specific for the S100 beta molecule, a calcium binding protein of astroglia.

1994 • 186 citations

Myelin oligodendrocyte glycoprotein induces a demyelinating encephalomyelitis resembling multiple sclerosis.

1995 • 185 citations

Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: dynamics of mRNA expression for interleukin-10, interleukin-12, cytolysin, tumor necrosis factor α and tumor necrosis factor β

1995 • 179 citations

Predominance of the autoimmune response to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis: Reactivity to the extracellular domain of MOG is directed against three main regions

1997 • 169 citations

Patterns of cytokine secretion by autoreactive proteolipid protein-specific T cell clones during the course of multiple sclerosis.

1995 • 166 citations

Demyelination Induced in Aggregating Brain Cell Cultures by a Monoclonal Antibody Against Myelin/Oligodendrocyte Glycoprotein

1990 • 165 citations

T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions.

1992 • 163 citations

Interferon γ, interleukin 4 and transforming growth factor β in experimental autoimmune encephalomyelitis in lewis rats: Dynamics of cellular mrna expression in the central nervous system and lymphoid cells

1995 • 159 citations

Chronic relapsing experimental autoimmune encephalomyelitis with a delayed onset and an atypical clinical course, induced in PL/J mice by myelin oligodendrocyte glycoprotein (MOG)‐derived peptide: Preliminary analysis of MOG T cell epitopes

1995 • 157 citations

The M2 autoantigen of central nervous system myelin, a glycoprotein present in oligodendrocyte membrane.

1986 • 151 citations

Myelin basic protein–specific T lymphocytes in multiple sclerosis and controls: Precursor frequency, fine specificity, and cytotoxicity

1992 • 149 citations

Diversity in fine specificity and T cell receptor usage of the human CD4+ cytotoxic T cell response specific for the immunodominant myelin basic protein peptide 87-106.

1992 • 148 citations

Immunologic Mechanisms and Therapy in Multiple Sclerosis

1995 • 147 citations

Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones.

1993 • 145 citations

T Helper 1 (TH1) Functional Phenotype of Human Myelin Basic Protein-Specific T Lymphocytes

1993 • 136 citations

The demyelinating potential of antibodies to myelin oligodendrocyte glycoprotein is related to their ability to fix complement

1991 • 136 citations

Skewed T-cell receptor repertoire in genetically identical twins correlates with multiple sclerosis

1993 • 134 citations

Oligodendrocyte-specific expression and autoantigenicity of transaldolase in multiple sclerosis.

1994 • 132 citations

Cytokine-producing cells in experimental autoimmune encephalomyelitis and multiple sclerosis

1995 • 132 citations

Myelin basic protein and proteolipid protein reactivity of brain- and cerebrospinal fluid-derived T cell clones in multiple sclerosis and postinfectious encephalomyelitis.

1987 • 127 citations

Cell-mediated immunity to myelin-associated glycoprotein, proteolipid protein, and myelin basic protein in multiple sclerosis

1986 • 124 citations

Myelin-oligodendrocyte glycoprotein (MOG) is a surface marker of oligodendrocyte maturation

1989 • 123 citations

T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans.

1995 • 121 citations

Multiple sclerosis: a pivotal role for the T cell in lesion development

1991 • 118 citations

Increased numbers of T cells recognizing multiple myelin basic protein epitopes in multiple sclerosis

1992 • 117 citations

Experimental allergic encephalomyelitis mediated by murine encephalitogenic T cell lines specific for myelin proteolipid apoprotein.

1987 • 115 citations

The autoimmune reactivity to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis is potentially pathogenic: Effect of copolymer 1 on MOG-induced disease

1996 • 109 citations

Encephalitogenic Th1 cells are inhibited by Th2 cells with related peptide specificity: Relative roles of interleukin (IL)-4 and IL-10

1993 • 101 citations

Review Human Th1 and Th2 Cells: Functional Properties, Regulation of Development and Role in Autoimmunity

1994 • 100 citations

Delineation of the minimal encephalitogenic epitope within the immunodominant region of myelin oligodendrocyte glycoprotein: diverse Vβ gene usage by T cells recognizing the core epitope encephalitogenic for T cell receptor Vβ^b and T cell receptor Vβ^a H‐2^b mice

1996 • 98 citations

Encephalitogenic Epitopes of Myelin Basic Protein

1989 • 89 citations

Purification and Partial Structural and Functional Characterization of Mouse Myelin/Oligodendrocyte Glycoprotein

1992 • 89 citations

Cytokine production by cells in cerebrospinal fluid during experimental allergic encephalomyelitis in SJL/J mice

1994 • 84 citations

Increased interleukin-6 mRNA expression in blood and cerebrospinal fluid mononuclear cells in multiple sclerosis

1996 • 83 citations

Lymphokines in Autoimmunity—A Critical Review

1994 • 82 citations

Diversity of T cell receptor α and β chain genes expressed by human T cells specific for similar myelin basic protein peptide/major histocompatibility complexes

1992 • 82 citations

Virus-reactive and autoreactive T cells are accumulated in cerebrospinal fluid in multiple sclerosis

1992 • 81 citations

Expression of heat shock genes (hsp70) in the mammalian brain: Distinguishing constitutively expressed and hyperthermia‐inducible mRNA species

1990 • 81 citations

Identification of a novel T cell epitope of human proteolipid protein (residues 40–60) recognized by proliferative and cytolytic CD4+ T cells from multiple sclerosis patients

1993 • 77 citations

Investigation of Myelin/Oligodendrocyte Glycoprotein Membrane Topology

1996 • 77 citations

Expression of heat shock protein‐65 by oligodendrocytes in vivo and in vitro

1992 • 75 citations

Restricted T cell expression of IL-2/IFN-gamma mRNA in human inflammatory disease.

1991 • 74 citations

Peptide determinants of myelin proteolipid protein (PLP) in autoimmune demyelinating disease: A review

1994 • 73 citations

Isolation and characterization of autoreactive moteolioid protein‐peptide specific T‐cell clones from multiple sclerosis patients

1995 • 72 citations

Predominant and stable T cell responses to regions of myelin basic protein can be detected in individual patients with multiple sclerosis

1993 • 66 citations

Common T‐cell receptor V_β usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis

1991 • 63 citations

Differential expression of heat shock proteins by human glial cells

1992 • 62 citations

Minireview: Autoimmune responses to myelin proteolipid protein

1994 • 59 citations

T-lymphocyte reactivity to the recombinant mycobacterial 65- and 70-kDa heat shock proteins in multiple sclerosis

1992 • 56 citations

Tumour necrosis factor-alpha synthesis by cerebrospinal-fluid-derived T cell clones from patients with multiple sclerosis

1991 • 55 citations

Sequence 104–117 of myelin proteolipid protein is a cryptic encephalitogenic T cell determinant for SJL/J mice

1995 • 53 citations

The T‐lymphocyte response against myelin‐associated glycoprotein and myelin basic protein in patients with multiple sclerosis

1993 • 46 citations

Characterization and Expression of the cDNA Coding for the Human Myelin/Oligodendrocyte Glycoprotein

1994 • 44 citations

T Cells Recognizing Multiple Peptides of Myelin Basic Protein are Found in Blood and Enriched in Cerebrospinal Fluid in Optic Neuritis and Multiple Sclerosis

1993 • 43 citations

Analysis of proteolipid protein (PLP)-specific T cells in multiple sclerosis: identification of PLP 95–116 as an HLA-DR2,w15-associated determinant

1995 • 42 citations

Heterogeneity of the T‐cell receptor β gene rearrangements generated in myelin basic protein‐specific T‐cell clones isolated from a patient with multiple sclerosis

1991 • 42 citations

Spinal fluid lymphocytes from a subgroup of multiple sclerosis patients respond to mycobacterial antigens

1993 • 42 citations

Human Myelin/Oligodendrocyte Glycoprotein: A New Member of the L2/HNK‐1 Family

1993 • 41 citations

Fine-specificity differences in the recognition of an encephalitogenic peptide by T helper 1 and 2 cells

1993 • 38 citations

Structure of the Human Myelin/Oligodendrocyte Glycoprotein Gene and Multiple Alternative Spliced Isoforms

1995 • 38 citations

Preparation of highly purified human myelin oligodendrocyte glycoprotein in quantities sufficient for encephalitogenicity and immunogenicity studies.

1993 • 34 citations

Identification of a second T cell epitore of human proteolipid protein (residues 89–106) recognized by proliferative and cytolytic CD4+ T cells from multiple sclerosis patients

1994 • 34 citations

2′,3′-cyclic nucleotide 3′-phosphodiesterase: a novel candidate autoantigen in demyelinating diseases

1997 • 33 citations

Stress proteins: their role in the normal central nervous system and in disease states, especially multiple sclerosis

1995 • 32 citations

A novel candidate autoantigen in a multiplex family with multiple sclerosis: prevalence of T-lymphocytes specific for an MBP epitope unique to myelination

1993 • 28 citations

Heterogeneity of T-cell receptor alpha-chain complementarity-determining region 3 in myelin basic protein-specific T cells increases with severity of multiple sclerosis.

1994 • 27 citations

Multiple sclerosis and its animal models: the role of the major histocompatibility complex and the T cell receptor repertoire

1992 • 26 citations

Are current immunological concepts of multiple sclerosis reflected by the immunopathology of its lesions?

1995 • 24 citations

Multiple sclerosis: effect of myelin basic protein on interleukin 1, interleukin 2 production and interleukin 2 receptor expression in vitro.

1988 • 23 citations

T cell receptor Vβ gene usage in the recognition of myelin basic protein by cerebrospinal fluid‐ and blood‐derived T cells from patients with multiple sclerosis

1994 • 18 citations

Constitutive expression of 65-kDa heat shock protein (HSP65)-like immunoreactivity in cultured mouse oligodendrocytes

1992 • 16 citations

Epitope specificity and V gene expression of cerebrospinal fluid T cells specific for intact versus cryptic epitopes of myelin basic protein

1993 • 11 citations

Characterization of in vivo-activated T cell clones from peripheral blood of multiple sclerosis patients

1991 • 8 citations

Anti-GM1 activity and Plasmacell Dyscrasia (PCD) in neurological patients: Identical or indipendent phenomena?

1994 • 1 citations