Epitope specificity and V gene expression of cerebrospinal fluid T cells specific for intact versus cryptic epitopes of myelin basic protein

New diagnostic criteria for multiple sclerosis: Guidelines for research protocols

1983 • 7,404 citations

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

1992 • 1,200 citations

Immunological Aspects of Demyelinating Diseases

1992 • 1,021 citations

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1990 • 906 citations

Intensive Immunosuppression in Progressive Multiple Sclerosis

1983 • 813 citations

Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis

1989 • 588 citations

T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination

1985 • 522 citations

Vaccination Against Experimental Allergic Encephalomyelitis with T Cell Receptor Peptides

1989 • 416 citations

Multiple Sclerosis

1982 • 415 citations

Limited heterogeneity of rearranged T-cell receptor Vα transcripts in brains of multiple sclerosis patients

1990 • 395 citations

Shared Human T Cell Receptor V _β Usage to Immunodominant Regions of Myelin Basic Protein

1990 • 386 citations

Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma.

1990 • 363 citations

Basic A1 Protein of the Myelin Membrane

1971 • 352 citations

Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals.

1990 • 342 citations

T and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis.

1991 • 314 citations

Further notes on disability evaluation in multiple sclerosis, with scale modifications

1965 • 310 citations

Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors.

1990 • 307 citations

Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls

1991 • 258 citations

The Choice of T‐Cell Epitopes Utilized on a Protein Antigen Depends on Multiple Factors Distant from, as well as at the Determinant Site

1987 • 247 citations

MS: a CNS and systematic autoimmune disease

1989 • 231 citations

A susceptibility locus for multiple sclerosis is linked to the T cell receptor β chain complex

1989 • 219 citations

T Cell Receptor Peptide Therapy Triggers Autoregulation of Experimental Encephalomyelitis

1991 • 202 citations

Implications of a Fab-like structure for the T-cell receptor

1989 • 193 citations

Restricted T-cell receptor V beta gene usage by myelin basic protein-specific T-cell clones in multiple sclerosis: predominant genes vary in individuals.

1991 • 193 citations

The V-region disease hypothesis: evidence from autoimmune encephalomyelitis

1989 • 190 citations

Frequency of T cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid in multiple sclerosis

1992 • 163 citations

T-cell receptor V alpha and C alpha alleles associated with multiple and myasthenia gravis.

1989 • 158 citations

THE FAMILY DOCTOR IN THE CONTEXT OF BRITAIN'S SOCIAL SERVICE.

1965 • 142 citations

Lymphocytes from SJL/J mice immunized with spinal cord respond selectively to a peptide of proteolipid protein and transfer relapsing demyelinating experimental autoimmune encephalomyelitis.

1991 • 130 citations

Myelin basic protein and proteolipid protein reactivity of brain- and cerebrospinal fluid-derived T cell clones in multiple sclerosis and postinfectious encephalomyelitis.

1987 • 127 citations

A synthetic peptide from myelin proteolipid protein induces experimental allergic encephalomyelitis.

1988 • 126 citations

THE GENETICS OF SUSCEPTIBILITY TO MULTIPLE SCLEROSIS1

1982 • 112 citations

THE MAJOR SITE OF GUINEA‐PIG MYELIN BASIC PROTEIN ENCEPHALITOGENIC IN LEWIS RATS¹²

1977 • 112 citations

On the immunopathology of plaque development and repair in multiple sclerosis

1988 • 102 citations

Antibodies specific for VB8 receptor peptide suppress experimental autoimmune encephalomyelitis.

1990 • 82 citations

Virus-reactive and autoreactive T cells are accumulated in cerebrospinal fluid in multiple sclerosis

1992 • 81 citations

HLA-linked and unlinked determinants of multiple sclerosis

1982 • 71 citations

Evidence for multiple human T cell recognition sites on myelin basic protein

1989 • 65 citations

Limiting dilution analysis of the frequency of antigen-reactive lymphocytes isolated from the central nervous system of Lewis rats with experimental allergic encephalomyelitis

1987 • 64 citations

Characterization and distribution of lymphocyte subpopulations in multiple sclerosis plaques versus autoimmune demyelinating lesions

1985 • 53 citations

Specificity of human T cell clones reactive to immunodominant epitopes of myelin basic protein

1991 • 43 citations

Selectin of encephalitogenic rat T‐Lymphocyte clones recognizing an immunodominant epitope on myelin basic protein

1989 • 42 citations

Characterization of the immune response to a secondary encephalitogenic epitope of basic protein in Lewis rats. I. T cell receptor peptide regulation of T cell clones expressing cross-reactive V beta genes.

1992 • 42 citations

Basic protein-specific T-cell lines that induce experimental autoimmune encephalomyelitis in SJL/J mice: Comparison with lewis rat lines

1988 • 41 citations

Epitopes of immunoreactive myelin basic protein in human cerebrospinal fluid

1986 • 40 citations

Preferential peptide specificity and HLA restriction of myelin basic protein-specific T cell clones derived from MS patients

1990 • 34 citations

Myelin basic protein specific T cell lines and clones derived from the CNS of rats with EAE only recognize encephalitogenic epitopes

1991 • 31 citations

TCR peptide therapy decreases the frequency of encephalitogenic T cells in the periphery and the central nervous system

1992 • 29 citations

Encephalitogenic T cell clones with variant receptor specificity.

1988 • 22 citations

Assessment of antigenic determinants for the human T cell response against myelin basic protein using overlapping synthetic peptides

1991 • 19 citations

The antigen-major histocompatibility complex-T cell receptor interaction

1988 • 9 citations

T lymphocytes in the cerebrospinal fluid of patients with multiple sclerosis

1990 • 2 citations