Encephalitogenic Th1 cells are inhibited by Th2 cells with related peptide specificity: Relative roles of interleukin (IL)-4 and IL-10

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

IL-10 inhibits cytokine production by activated macrophages.

1991 • 2,919 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

1991 • 1,950 citations

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

1991 • 1,880 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

1992 • 1,290 citations

Macrophage deactivation by interleukin 10.

1991 • 1,253 citations

Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones.

1987 • 966 citations

IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages.

1992 • 709 citations

Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones.

1992 • 697 citations

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

1990 • 692 citations

Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery.

1992 • 627 citations

T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination

1985 • 522 citations

Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells.

1990 • 487 citations

IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function.

1992 • 375 citations

Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice.

1989 • 372 citations

Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations.

1991 • 355 citations

Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation.

1992 • 352 citations

Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice

1984 • 311 citations

Regulation of T‐Cell Activation; Differences among T‐Cell Subsets

1989 • 271 citations

Infection with Schistosoma mansoni alters Th1/Th2 cytokine responses to a non-parasite antigen.

1992 • 256 citations

Evidence implicating utilization of different T cell receptor-associated signaling pathways by TH1 and TH2 clones.

1990 • 218 citations

The fine structure of chronically active multiple sclerosis plaques

1978 • 190 citations

Autocrine growth of CD4+ T cells. Differential effects of IL-1 on helper and inflammatory T cells.

1988 • 183 citations

Heterogeneity of helper/inducer T lymphocytes. III. Responses of IL-2- and IL-4-producing (Th1 and Th2) clones to antigens presented by different accessory cells.

1990 • 144 citations

Cytokine secretion patterns and cross-regulation of T cell subsets

1991 • 127 citations

Immunotherapy of multiple sclerosis

1988 • 113 citations

The involvement of human tumor necrosis factors-alpha and -beta in the mixed lymphocyte reaction.

1988 • 111 citations

IL-4 suppresses cytokine gene expression induced by IFN-gamma and/or IL-2 in murine peritoneal macrophages.

1992 • 110 citations

Changes in the precursor frequencies of IL-4 and IFN-gamma secreting CD4+ cells correlate with resolution of lesions in murine cutaneous leishmaniasis.

1992 • 104 citations

Attachment of myelin to coated pits on macrophages in experimental allergic encephalomyelitis

1983 • 88 citations

Murine B7 antigen provides a sufficient costimulatory signal for antigen-specific and MHC-restricted T cell activation.

1992 • 83 citations

Anti-inflammatory action of IL-4. Negative regulation of contact sensitivity to trinitrochlorobenzene.

1992 • 80 citations

A repetitive peptide of Leishmania can activate T helper type 2 cells and enhance disease progression.

1990 • 61 citations

The role of macrophages in demyelination

1992 • 60 citations

Fine-specificity differences in the recognition of an encephalitogenic peptide by T helper 1 and 2 cells

1993 • 38 citations

The development and characterization of encephalitogenic cloned T cells specific for myelin proteolipid protein

1990 • 35 citations

Vaccine-induced CD4+ T cells against the simian immunodeficiency virus gag protein. Epitope specificity and relevance to protective immunity.

1991 • 32 citations

Immune processing of proteolipid protein by subsets of antigen-presenting spleen cells

1992 • 16 citations

Characterization of accessory cell costimulation of Th1 cytokine synthesis.

1991 • 14 citations

Myelin Basic Protein-Specific T Cell Clones and Experimental Allergic Encephalomyelitis

1986 • 10 citations