Notch, Epidermal Growth Factor Receptor, and β1-Integrin Pathways Are Coordinated in Neural Stem Cells

Lipid rafts and signal transduction

2000 • 6,079 citations

Generation of Neurons and Astrocytes from Isolated Cells of the Adult Mammalian Central Nervous System

1992 • 5,296 citations

Convergence of Wnt, ß-Catenin, and Cadherin Pathways

2004 • 2,451 citations

Structure and Function of Sphingolipid- and Cholesterol-rich Membrane Rafts

2000 • 2,321 citations

"Stemness": Transcriptional Profiling of Embryonic and Adult Stem Cells

2002 • 1,721 citations

A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes

1992 • 1,514 citations

Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture

2003 • 1,497 citations

Lipid Rafts

2003 • 1,485 citations

Embryonic Stem Cells Express Neuronal Properties in Vitro

1995 • 1,173 citations

Global Conformational Rearrangements in Integrin Extracellular Domains in Outside-In and Inside-Out Signaling

2002 • 1,134 citations

Embryonic Stem Cell-Derived Glial Precursors: A Source of Myelinating Transplants

1999 • 981 citations

A unified hypothesis on the lineage of neural stem cells

2001 • 976 citations

Direct Neural Fate Specification from Embryonic Stem Cells

2001 • 754 citations

Radial Glial Identity Is Promoted by Notch1 Signaling in the Murine Forebrain

2000 • 716 citations

The glial identity of neural stem cells

2003 • 710 citations

Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells

2002 • 674 citations

LeX/ssea-1 Is Expressed by Adult Mouse CNS Stem Cells, Identifying Them as Nonependymal

2002 • 662 citations

Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis

2003 • 637 citations

Reciprocal interactions between β1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: A different perspective in epithelial biology

1998 • 625 citations

Caveolae: where incoming and outgoing messengers meet.

1993 • 616 citations

The Role of Notch in Promoting Glial and Neural Stem Cell Fates

2002 • 590 citations

Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival

1998 • 574 citations

Contact-Dependent Inhibition of Cortical Neurite Growth Mediated by Notch Signaling

1999 • 568 citations

Integrins Regulate Rac Targeting by Internalization of Membrane Domains

2004 • 533 citations

Regulation of Notch Signaling Activity

2004 • 449 citations

Differentiation of mouse embryonic stem cells into a defined neuronal lineage

2004 • 449 citations

Phospho-caveolin-1 mediates integrin-regulated membrane domain internalization

2005 • 414 citations

Notch signalling and the control of cell fate choices in vertebrates

1998 • 410 citations

Identification and isolation of human prostate epithelial stem cells based on α2β1-integrin expression

2001 • 362 citations

Cross-talk between the Notch and TGF-β signaling pathways mediated by interaction of the Notch intracellular domain with Smad3

2003 • 360 citations

Response Diversity and the Timing of Progenitor Cell Maturation Are Regulated by Developmental Changes in EGFR Expression in the Cortex

1997 • 329 citations

Radial Glial Cells

2005 • 310 citations

β1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance

2004 • 308 citations

β1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis

2003 • 303 citations

The involvement of lipid rafts in the regulation of integrin function

2002 • 302 citations

Essential role of α6 integrins in cortical and retinal lamination

1998 • 301 citations

Hes1andHes5Activities Are Required for the Normal Development of the Hair Cells in the Mammalian Inner Ear

2001 • 286 citations

Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis

1997 • 278 citations

Delta-Notch signaling controls the generation of neurons/glia from neural stem cells in a stepwise process

2003 • 278 citations

Neural precursor cell chain migration and division are regulated through different β1 integrins

1998 • 265 citations

Requirement for Dynamin during Notch Signaling inDrosophilaNeurogenesis

1997 • 265 citations

Combinatorial Signaling in the Specification of Unique Cell Fates

2000 • 260 citations

Reelin, Disabled 1, and β ₁ integrins are required for the formation of the radial glial scaffold in the hippocampus

2002 • 255 citations

DrosophilaEpsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch

2004 • 246 citations

The Anti-apoptotic Effect of Notch-1 Requires p56 -dependent, Akt/PKB-mediated Signaling in T Cells

2004 • 238 citations

Integrin and ECM functions: roles in vertebrate development

2000 • 234 citations

Notch and the Immune System

2003 • 220 citations

Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells

2003 • 215 citations

BMP and FGF regulate the development of EGF-responsive neural progenitor cells

2000 • 187 citations

Fibroblast Growth Factor Receptor Signaling Promotes Radial Glial Identity and Interacts with Notch1 Signaling in Telencephalic Progenitors

2004 • 184 citations

Epidermal Growth Factor Receptor-Dependent Regulation of Integrin-Mediated Signaling and Cell Cycle Entry in Epithelial Cells

2004 • 180 citations

Neurospheres: Insights into neural stem cell biology

2004 • 168 citations

Activated Notch4 Inhibits Angiogenesis: Role of β1-Integrin Activation

2002 • 164 citations

Glycoprotein 130 Signaling RegulatesNotch1Expression and Activation in the Self-Renewal of Mammalian Forebrain Neural Stem Cells

2003 • 164 citations

Spatial and temporal control of signaling through lipid rafts

2004 • 162 citations

A Role for Abl in Notch Signaling

1998 • 161 citations

Lipid rafts make for slippery platforms

2003 • 160 citations

Regulation of neural progenitor proliferation and survival by β1 integrins

2005 • 156 citations

Regulation of Integrin Growth Factor Interactions in Oligodendrocytes by Lipid Raft Microdomains

2003 • 152 citations

Separate Proliferation Kinetics of Fibroblast Growth Factor-Responsive and Epidermal Growth Factor-Responsive Neural Stem Cells within the Embryonic Forebrain Germinal Zone

2000 • 151 citations

Cell Cycle Arrest and Apoptosis Induced by Notch1 in B Cells

2000 • 146 citations

Integrin α5/β1 Mediates Fibronectin-dependent Epithelial Cell Proliferation through Epidermal Growth Factor Receptor Activation

2000 • 144 citations

Autonomous and non-autonomous regulation of mammalian neurite development by Notch1 and Delta1

1999 • 143 citations

Normal timing of oligodendrocyte development from genetically engineered,lineage-selectable mouse ES cells

2002 • 136 citations

Increased survival of rat EGF-generated CNS precursor cells using B27 supplemented medium

1995 • 136 citations

Suppression of differentiation and proliferation of early chondrogenic cells by Notch

2003 • 120 citations

Interactions between Fibroblast Growth Factors and Notch Regulate Neuronal Differentiation

2001 • 111 citations

The stem cell compartment in human interfollicular epidermis

2002 • 108 citations

β1 integrins and neural stem cells: making sense of the extracellular environment

2005 • 107 citations

Lipid Rafts and Integrin Activation Regulate Oligodendrocyte Survival

2004 • 102 citations

The EGF receptor and N signalling pathways act antagonistically in Drosophila mesothorax bristle patterning

2001 • 99 citations

The regulation of apoptosis by Numb/Notch signaling in the serotonin lineage ofDrosophila

2003 • 85 citations

Cell–matrix interactions during development and apoptosis of the mouse mammary gland in vivo

2002 • 83 citations

Differentiation of radial glia‐like cells from embryonic stem cells

2003 • 68 citations

Roles of lipid rafts in integrin‐dependent adhesion and gp130 signalling pathway in mouse embryonic neural precursor cells

2004 • 62 citations

mDll1 and mDll3 expression in the developing mouse brain: Role in the establishment of the early cortex

2001 • 48 citations

Basic fibroblast growth factor upregulates steady-state levels of laminin B1 and B2 chain mRNA in cultured neuroepithelial cells

1991 • 35 citations

Brain or Brawn

2003 • 20 citations

Developmental Biology: Notching the Hindbrain

2004 • 4 citations