Regulation of Notch Signaling Activity

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1991 • 1,693 citations

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1998 • 1,600 citations

Signalling downstream of activated mammalian Notch

1995 • 1,375 citations

Regulated Intramembrane Proteolysis

2000 • 1,314 citations

A Novel Proteolytic Cleavage Involved in Notch Signaling

2000 • 1,080 citations

Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex

2003 • 933 citations

Fringe is a glycosyltransferase that modifies Notch

2000 • 846 citations

A Ligand-Induced Extracellular Cleavage Regulates γ-Secretase-like Proteolytic Activation of Notch1

2000 • 841 citations

Mind Bomb Is a Ubiquitin Ligase that Is Essential for Efficient Activation of Notch Signaling by Delta

2003 • 773 citations

Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells

1994 • 749 citations

The Notch1 receptor is cleaved constitutively by a furin-like convertase

1998 • 720 citations

Glycosyltransferase activity of Fringe modulates Notch–Delta interactions

2000 • 686 citations

Control of Daughter Cell Fates during Asymmetric Division: Interaction of Numb and Notch

1996 • 656 citations

UBIQUITIN AND THE CONTROL OF PROTEIN FATE IN THE SECRETORY AND ENDOCYTIC PATHWAYS

1998 • 617 citations

A histone deacetylase corepressor complex regulates the Notch signal transduction pathway

1998 • 587 citations

Fringe modulates Notch–ligand interactions

1997 • 578 citations

The Segmentation Clock: Converting Embryonic Time into Spatial Pattern

2003 • 523 citations

Ligand endocytosis drives receptor dissociation and activation in the Notch pathway

2000 • 492 citations

A CBP Binding Transcriptional Repressor Produced by the PS1/ϵ-Cleavage of N-Cadherin Is Inhibited by PS1 FAD Mutations

2003 • 468 citations

Intrinsic activity of the lin-12 and Notch intracellular domains in vivo

1993 • 466 citations

Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor

1993 • 424 citations

Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei.

1993 • 421 citations

Requirements for Presenilin-Dependent Cleavage of Notch and Other Transmembrane Proteins

2000 • 418 citations

Numb Antagonizes Notch Signaling to Specify Sibling Neuron Cell Fates

1996 • 415 citations

Processing of the Notch Ligand Delta by the Metalloprotease Kuzbanian

1999 • 413 citations

Calcium Depletion Dissociates and Activates Heterodimeric Notch Receptors

2000 • 411 citations

Notch signalling and the control of cell fate choices in vertebrates

1998 • 410 citations

The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate

1997 • 407 citations

The Notch Intracellular Domain Is Ubiquitinated and Negatively Regulated by the Mammalian Sel-10 Homolog

2001 • 401 citations

Functional Interaction between SEL-10, an F-box Protein, and the Nuclear Form of Activated Notch1 Receptor

2001 • 374 citations

Regulation of Notch Signaling by O-Linked Fucose

2002 • 369 citations

Protein O -fucosyltransferase 1 is an essential component of Notch signaling pathways

2003 • 365 citations

Regulation of Transcriptional Activation Domain Function by Ubiquitin

2001 • 363 citations

Numb Is an Endocytic Protein

2000 • 357 citations

The Endocytic Protein α-Adaptin Is Required for Numb-Mediated Asymmetric Cell Division in Drosophila

2002 • 355 citations

The Notch Ligands, Jagged and Delta, Are Sequentially Processed by α-Secretase and Presenilin/γ-Secretase and Release Signaling Fragments

2003 • 353 citations

Drosophila Neuralized Is a Ubiquitin Ligase that Promotes the Internalization and Degradation of Delta

2001 • 333 citations

SEL-10 Is an Inhibitor of Notch Signaling That Targets Notch for Ubiquitin-Mediated Protein Degradation

2001 • 328 citations

Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats

1995 • 324 citations

Recognition and Ubiquitination of Notch by Itch, a Hect-type E3 Ubiquitin Ligase

2000 • 321 citations

CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex

1999 • 301 citations

Requirement for Dynamin during Notch Signaling inDrosophilaNeurogenesis

1997 • 265 citations

neuralized Encodes a Peripheral Membrane Protein Involved in Delta Signaling and Endocytosis

2001 • 258 citations

Glycogen Synthase Kinase-3β Modulates Notch Signaling and Stability

2002 • 255 citations

Asymmetric localization of numb autonomously determines sibling neuron identity in the Drosophila CNS

1995 • 249 citations

The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and γ-secretase

2003 • 245 citations

Unequal Segregation of Neuralized Biases Notch Activation during Asymmetric Cell Division

2003 • 236 citations

sel-10, a negative regulator of lin-12 activity inCaenorhabditis elegans, encodes a member of the CDC4 family of proteins

1997 • 234 citations

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1

2002 • 231 citations

kuzbanian-mediated cleavage of Drosophila Notch

2002 • 226 citations

Xenopus Neuralized Is a Ubiquitin Ligase that Interacts with XDelta1 and Regulates Notch Signaling

2001 • 225 citations

Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development

1993 • 222 citations

CSL-independent Notch signalling: a checkpoint in cell fate decisions during development?

2002 • 216 citations

Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless

2002 • 215 citations

Repression by Suppressor of Hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo

2000 • 212 citations

Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway

1994 • 209 citations

Structural conservation of Notch receptors and ligands

1998 • 201 citations

The γ-secretase-generated intracellular domain of β-amyloid precursor protein binds Numb and inhibits Notch signaling

2002 • 197 citations

The Notch Ligands, Delta1 and Jagged2, Are Substrates for Presenilin-dependent “γ-Secretase” Cleavage

2003 • 195 citations

Notch signalling inDrosophila: three ways to use a pathway

1998 • 195 citations

Modulation of Notch-Ligand Binding by Protein O-Fucosyltransferase 1 and Fringe

2003 • 191 citations

LAG-3 is a putative transcriptional activator in the C. elegans Notch pathway

2000 • 190 citations

Notch signalling pathway and human diseases

1998 • 190 citations

Fringe, Notch, and making developmental boundaries

1999 • 189 citations

Notch pathway: Making sense of Suppressor of Hairless

2001 • 182 citations

Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate

2001 • 180 citations

An EGFR/Ebi/Sno Pathway Promotes Delta Expression by Inactivating Su(H)/SMRTER Repression during Inductive Notch Signaling

2002 • 174 citations

LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation

2002 • 173 citations

Transcriptional repression by Suppressor of Hairless involves the binding of a Hairless-dCtBP complex in Drosophila

2001 • 172 citations

Notch Ligands Are Substrates for ProteinO-Fucosyltransferase-1 and Fringe

2002 • 168 citations

JNK signaling and morphogenesis in Drosophila

1998 • 163 citations

Numb Inhibits Membrane Localization of Sanpodo, a Four-Pass Transmembrane Protein, to Promote Asymmetric Divisions in Drosophila

2003 • 161 citations

neurotic, a novel maternal neurogenic gene, encodes anO-fucosyltransferase that is essential for Notch-Delta interactions

2003 • 161 citations

Interchangeability of Caenorhabditis elegans DSL proteins and intrinsic signalling activity of their extracellular domains in vivo

1995 • 159 citations

Nature versus nurture: Asymmetric cell divisions in Drosophila bristle development

1994 • 155 citations

The Drosophila melanogaster Suppressor of deltex Gene, a Regulator of the Notch Receptor Signaling Pathway, Is an E3 Class Ubiquitin Ligase

1999 • 154 citations

Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans

2002 • 152 citations

Spatially Restricted Factors Cooperate with Notch in the Regulation of Enhancer of split Genes

2000 • 149 citations

SCORE: A computational approach to the identification of cis-regulatory modules and target genes in whole-genome sequence data

2002 • 148 citations

Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila

1997 • 147 citations

Altered Epidermal Growth Factor-like sequences provide evidence for a role of Notch as a receptor in cell fate decisions

1993 • 147 citations

Fringe Modifies O-Fucose on Mouse Notch1 at Epidermal Growth Factor-like Repeats within the Ligand-binding Site and the Abruptex Region

2003 • 144 citations

Different cofactor activities in γ-secretase assembly

2003 • 139 citations

Notch-induced Proteolysis and Nuclear Localization of the Delta Ligand

2003 • 136 citations

Intracellular Cell-Autonomous Association of Notch and Its Ligands: A Novel Mechanism of Notch Signal Modification

2002 • 131 citations

An Intrinsic Dominant Negative Activity of Serrate That Is Modulated during Wing Development inDrosophila

1997 • 124 citations

The Abruptex domain of Notch regulates negative interactions between Notch, its ligands and Fringe

2000 • 122 citations

An activity of Notch regulates JNK signalling and affects dorsal closure in Drosophila

1999 • 120 citations

Planar polarity and actin dynamics in the epidermis of Drosophila

2002 • 118 citations

Notch and Presenilin: a proteolytic mechanism emerges

2001 • 106 citations

Down-regulation of Delta by proteolytic processing

2002 • 104 citations

Complex Proteolytic Processing Acts on Delta, a Transmembrane Ligand for Notch, duringDrosophilaDevelopment

1998 • 103 citations

Involvement of a proline-rich motif and RING-H2 finger of Deltex in the regulation of Notch signaling

2002 • 102 citations

Siah-1 binds and regulates the function of Numb

2001 • 96 citations

Furin cleavage is not a requirement for Drosophila Notch function

2002 • 91 citations

AnO-fucose site in the ligand binding domain inhibits Notch activation

2003 • 90 citations

Notch Signaling: Endocytosis Makes Delta Signal Better

2003 • 87 citations

Dominant-negative mutation in the β2 and β6 proteasome subunit genes affect alternative cell fate decisions in the Drosophila sense organ lineage

1999 • 81 citations

Fringe forms a complex with Notch

2000 • 75 citations

Notch activity in neural cells triggered by a mutant allele with altered glycosylation

2003 • 38 citations