The regulation of apoptosis by Numb/Notch signaling in the serotonin lineage ofDrosophila

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

DEVELOPMENT IN DROSOPHILA MELANOGASTER

1927 • 2,909 citations

Genetic Control of Programmed Cell Death in Drosophila

1994 • 1,028 citations

Notch Signaling: From the Outside In

2000 • 958 citations

Cooperative Regulation of Cell Polarity and Growth by Drosophila Tumor Suppressors

2000 • 908 citations

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.

1996 • 717 citations

Programmed cell death during Drosophila embryogenesis

1993 • 710 citations

Drosophila Neuroblasts Sequentially Express Transcription Factors which Specify the Temporal Identity of Their Neuronal Progeny

2001 • 667 citations

Notch is required for successive cell decisions in the developing Drosophila retina.

1989 • 473 citations

Malignant Neoplasms of Genetic Origin in Drosophila melanogaster

1978 • 441 citations

Dlg protein is required for junction structure, cell polarity, and proliferation control in Drosophila epithelia.

1996 • 422 citations

Clonal analysis ofDrosophilaembryonic neuroblasts: neural cell types, axon projections and muscle targets

1999 • 417 citations

Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma

2002 • 407 citations

Cell death in normal and rough eye mutants of Drosophila

1991 • 364 citations

The Endocytic Protein α-Adaptin Is Required for Numb-Mediated Asymmetric Cell Division in Drosophila

2002 • 355 citations

Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts

2002 • 352 citations

Correlating Notch Signaling with Thymocyte Maturation

1998 • 350 citations

The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts

2000 • 332 citations

Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast

2000 • 326 citations

Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation.

1996 • 316 citations

The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage.

1996 • 313 citations

Genetic control of Drosophila nerve cord development

2003 • 266 citations

Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation

2002 • 259 citations

Notch1 is required for neuronal and glial differentiation in the cerebellum

2002 • 259 citations

NUMB Localizes in the Basal Cortex of Mitotic Avian Neuroepithelial Cells and Modulates Neuronal Differentiation by Binding to NOTCH-1

1999 • 256 citations

Arbiter of differentiation and death: Notch signaling meets apoptosis

1999 • 255 citations

An instructive function for Notch in promoting gliogenesis in the zebrafish retina

2001 • 244 citations

The role of segment polarity genes during Drosophila neurogenesis.

1989 • 235 citations

Cutting Edge: Protective Effects of Notch-1 on TCR-Induced Apoptosis

1999 • 223 citations

Serotonin‐containing neurons in Drosophila melanogaster: Development and distribution

1988 • 209 citations

Sanpodo and Notch act in opposition to Numb to distinguish sibling neuron fates in the Drosophila CNS

1998 • 199 citations

Asymmetric segregation of Numb: a mechanism for neural specification from Drosophila to mammals

2002 • 186 citations

Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage

1999 • 183 citations

Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate

2001 • 180 citations

Neural stem cells and regulation of cell number

2002 • 176 citations

Catecholamine‐containing neurons in Drosophila melanogaster: Distribution and development

1988 • 176 citations

A pathway of signals regulating effector and initiator caspases in the developingDrosophilaeye

2002 • 175 citations

The pattern of proliferation of the neuroblasts in the wild-type embryo of Drosophila melanogaster

1987 • 160 citations

Hunchback is required for the specification of the early sublineage of neuroblast 7-3 in theDrosophilacentral nervous system

2002 • 159 citations

Characterization of a novel subset of cardiac cells and their progenitors in theDrosophilaembryo

2000 • 151 citations

Cell Cycle Arrest and Apoptosis Induced by Notch1 in B Cells

2000 • 146 citations

Control of Cell Divisions in the Nervous System: Symmetry and Asymmetry

2000 • 128 citations

The differentiation of the serotonergic neurons in the Drosophila ventral nerve cord depends on the combined function of the zinc finger proteins Eagle and Huckebein

1997 • 115 citations

eagle, a member of the steroid receptor gene superfamily, is expressed in a subset of neuroblasts and regulates the fate of their putative progeny in the Drosophila CNS

1996 • 109 citations

Mesodermal cell fate decisions in Drosophila are under the control of the lineage genes numb, Notch, and sanpodo

1998 • 109 citations

Notch-1 inhibits apoptosis in murine erythroleukemia cells and is necessary for differentiation induced by hybrid polar compounds

1999 • 108 citations

Binary sibling neuronal cell fate decisions in the Drosophila embryonic central nervous system are nonstochastic and require inscuteable-mediated asymmetry of ganglion mother cells

1998 • 106 citations

Apoptotic Activities of Wild-Type and Alzheimer's Disease-Related Mutant Presenilins in Drosophila melanogaster

1999 • 104 citations

P element insertion-dependent gene activation in the Drosophila eye

1997 • 102 citations

The Drosophila sanpodo gene controls sibling cell fate and encodes a tropomodulin homolog, an actin/tropomyosin-associated protein

1998 • 93 citations

Short-Range Cell Interactions and Cell Survival in the Drosophila Wing

2002 • 92 citations

The tumor suppressor gene, lethal(2)giant larvae (l(2)gl), is required for cell shape change of epithelial cells during Drosophila development

1996 • 91 citations

Notch and Wingless Regulate Expression of Cuticle Patterning Genes

1999 • 88 citations

P-Element Insertion Alleles of Essential Genes on the Third Chromosome of Drosophila melanogaster: Mutations Affecting Embryonic PNS Development

1997 • 87 citations

Programmed cell death and patterning in Drosophila

2000 • 83 citations

Cellular diversity in the developing nervous system: a temporal view fromDrosophila

2002 • 79 citations

The Abruptex Mutations of Notch Disrupt the Establishment of Proneural Clusters in Drosophila

1999 • 75 citations

TheengrailedandhuckebeinGenes Are Essential for Development of Serotonin Neurons in theDrosophilaCNS

1996 • 73 citations

Determinants of Neuronal Identity

1992 • 72 citations

eagle is required for the specification of serotonin neurons and other neuroblast 7-3 progeny in the Drosophila CNS

1998 • 72 citations

Establishing neuroblast-specific gene expression in the Drosophila CNS: huckebein is activated by Wingless and Hedgehog and repressed by Engrailed and Gooseberry

1997 • 59 citations

The zfh-2 gene product is a potential regulator of neuron-specific DOPA decarboxylase gene expression in Drosophila

1992 • 58 citations

Advances in developmental biochemistry

1992 • 53 citations

Markers and characteristics of human SCLC cell lines

1987 • 52 citations

Binary cell death decision regulated by unequal partitioning of Numb at mitosis

2002 • 45 citations

Notch signaling targets the Wingless responsiveness of a Ubx visceral mesoderm enhancer in Drosophila

2001 • 45 citations

Cell interactions within nascent neural crest cell populations transiently promote death of neurogenic precursors

2000 • 39 citations

huckebein is required for glial development and axon pathfinding in the neuroblast 1-1 and neuroblast 2-2 lineages in the Drosophila central nervous system

1996 • 31 citations

The Generation of Neuronal Diversity in the Drosophila Embryonic Central Nervous System

1992 • 23 citations

Regulation of the DOPA Decarboxylase Gene During Drosophila Development

1994 • 9 citations