β1 integrins and neural stem cells: making sense of the extracellular environment

Integrins

2002 • 8,127 citations

Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain

1999 • 3,822 citations

Osteoblastic cells regulate the haematopoietic stem cell niche

2003 • 3,370 citations

Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation

1996 • 3,079 citations

Identification of the haematopoietic stem cell niche and control of the niche size

2003 • 2,900 citations

Out of Eden: Stem Cells and Their Niches

2000 • 1,769 citations

The development of neural stem cells

2001 • 1,474 citations

Integrin signalling during tumour progression

2004 • 1,430 citations

Stem cells find their niche

2001 • 1,428 citations

Neurogenesis in Adult Subventricular Zone

2002 • 1,415 citations

Neural stem cells in the adult mammalian forebrain: A relatively quiescent subpopulation of subependymal cells

1994 • 1,400 citations

For the Long Run

2004 • 1,289 citations

Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase

1996 • 1,106 citations

Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression

1993 • 1,102 citations

A unified hypothesis on the lineage of neural stem cells

2001 • 976 citations

Asymmetric Inheritance of Radial Glial Fibers by Cortical Neurons

2001 • 871 citations

Stem cell patterning and fate in human epidermis

1995 • 788 citations

Networks and crosstalk: integrin signalling spreads

2002 • 777 citations

Orientation of Asymmetric Stem Cell Division by the APC Tumor Suppressor and Centrosome

2003 • 727 citations

Consequences of lack of beta 1 integrin gene expression in mice.

1995 • 724 citations

Coordinated Interaction of Neurogenesis and Angiogenesis in the Adult Songbird Brain

2002 • 718 citations

Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor.

1994 • 712 citations

The glial identity of neural stem cells

2003 • 710 citations

LeX/ssea-1 Is Expressed by Adult Mouse CNS Stem Cells, Identifying Them as Nonependymal

2002 • 662 citations

The cell cycle of the pseudostratified ventricular epithelium of the embryonic murine cerebral wall

1995 • 662 citations

Functions of heparan sulfate proteoglycans in cell signaling during development

2004 • 659 citations

The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression.

1995 • 627 citations

Reciprocal interactions between β1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: A different perspective in epithelial biology

1998 • 625 citations

A niche for adult neural stem cells

2003 • 612 citations

Dividing Precursor Cells of the Embryonic Cortical Ventricular Zone Have Morphological and Molecular Characteristics of Radial Glia

2002 • 607 citations

Basic Helix-Loop-Helix Factors in Cortical Development

2003 • 601 citations

Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival

1998 • 574 citations

β1-Class Integrins Regulate the Development of Laminae and Folia in the Cerebral and Cerebellar Cortex

2001 • 555 citations

Development of glial cells in the cerebral wall of ferrets: Direct tracing of their transformation from radial glia into astrocytes

1989 • 544 citations

Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins

2001 • 544 citations

Basic Fibroblast Growth Factor (Fgf2) Is Necessary for Cell Proliferation and Neurogenesis in the Developing Cerebral Cortex

2000 • 419 citations

Integrin β cytoplasmic domain interactions with phosphotyrosine-binding domains: A structural prototype for diversity in integrin signaling

2003 • 404 citations

Targeted disruption of β1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction

2004 • 402 citations

Radial glia: multi-purpose cells for vertebrate brain development

2002 • 373 citations

Cross-talk between the Notch and TGF-β signaling pathways mediated by interaction of the Notch intracellular domain with Smad3

2003 • 360 citations

The spatial relationship between stem cells and their progeny in the basal layer of human epidermis: a new view based on whole-mount labelling and lineage analysis

1999 • 359 citations

Developmental and Evolutionary Adaptations of Cortical Radial Glia

2003 • 348 citations

Signaling from E-cadherins to the MAPK Pathway by the Recruitment and Activation of Epidermal Growth Factor Receptors upon Cell-Cell Contact Formation

2000 • 345 citations

Distinct Functions of α3 and αV Integrin Receptors in Neuronal Migration and Laminar Organization of the Cerebral Cortex

1999 • 344 citations

Sequence of Neuron Origin and Neocortical Laminar Fate: Relation to Cell Cycle of Origin in the Developing Murine Cerebral Wall

1999 • 320 citations

β1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance

2004 • 308 citations

Generation of an environmental niche for neural stem cell development by the extracellular matrix molecule tenascin C

2004 • 308 citations

In vivo clonal analyses reveal the properties of endogenous neural stem cell proliferation in the adult mammalian forebrain

1998 • 304 citations

β1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis

2003 • 303 citations

Essential role of α6 integrins in cortical and retinal lamination

1998 • 301 citations

Integrin regulation of growth factor receptors

2002 • 295 citations

Integrin-Mediated Survival Signals Regulate the Apoptotic Function of Bax through Its Conformation and Subcellular Localization

2000 • 293 citations

The Role of Laminin in Embryonic Cell Polarization and Tissue Organization

2003 • 288 citations

Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis

1997 • 278 citations

Elusive radial glial cells: Historical and evolutionary perspective

2003 • 271 citations

Phenotypic Reversion or Death of Cancer Cells by Altering Signaling Pathways in Three-Dimensional Contexts

2002 • 268 citations

Neural precursor cell chain migration and division are regulated through different β1 integrins

1998 • 265 citations

The Epidermal Growth Factor Receptor Modulates the Interaction of E-cadherin with the Actin Cytoskeleton

1998 • 259 citations

Reelin, Disabled 1, and β ₁ integrins are required for the formation of the radial glial scaffold in the hippocampus

2002 • 255 citations

Interactions between growth factor receptors and adhesion molecules: breaking the rules

2003 • 250 citations

CNS integrins switch growth factor signalling to promote target-dependent survival

2002 • 246 citations

Adherens junctions inhibit asymmetric division in the Drosophila epithelium

2001 • 237 citations

Integrin and ECM functions: roles in vertebrate development

2000 • 234 citations

The presence of FGF2 signaling determines whether β-catenin exerts effects on proliferation or neuronal differentiation of neural stem cells

2004 • 233 citations

Intrinsic Polarity of Mammalian Neuroepithelial Cells

1998 • 216 citations

Characterization of the human nestin gene reveals a close evolutionary relationship to neurofilaments

1992 • 214 citations

Integrin-ECM Interactions Regulate Cadherin-Dependent Cell Adhesion and Are Required for Convergent Extension in Xenopus

2003 • 209 citations

Integrin alpha subunit ratios, cytoplasmic domains, and growth factor synergy regulate muscle proliferation and differentiation.

1996 • 195 citations

BMP and FGF regulate the development of EGF-responsive neural progenitor cells

2000 • 187 citations

Role of FGFs/FGFRs in skeletal development and bone regeneration

2012 • 173 citations

Regulation of E-cadherin expression and β-catenin/Tcf transcriptional activity by the integrin-linked kinase

2003 • 162 citations

NEW EMBO MEMBER'S REVIEW: Regulation of neuronal survival and death by extracellular signals during development

2003 • 159 citations

Regulation of neural progenitor proliferation and survival by β1 integrins

2005 • 156 citations

Separate Proliferation Kinetics of Fibroblast Growth Factor-Responsive and Epidermal Growth Factor-Responsive Neural Stem Cells within the Embryonic Forebrain Germinal Zone

2000 • 151 citations

α3β1 integrin–CD151, a component of the cadherin–catenin complex, regulates PTPμ expression and cell–cell adhesion

2003 • 150 citations

Rac Activation upon Cell-Cell Contact Formation Is Dependent on Signaling from the Epidermal Growth Factor Receptor

2002 • 146 citations

Neurogenesis in Embryos and in Adult Neural Stem Cells

2002 • 138 citations

Role of Integrins in the Development of the Cerebral Cortex

2003 • 129 citations

Integrin α5β1 supports the migration of Xenopus cranial neural crest on fibronectin

2003 • 122 citations

Developmental Regulation of β1 Integrins during Angiogenesis in the Central Nervous System

2002 • 118 citations

Specific β1 integrins mediate adhesion, migration, and differentiation of neural progenitors derived from the embryonic striatum

2004 • 114 citations

α3β1 integrin promotes keratinocyte cell survival through activation of a MEK/ERK signaling pathway

2004 • 111 citations

Interactions between Fibroblast Growth Factors and Notch Regulate Neuronal Differentiation

2001 • 111 citations

Glial process elongation and branching in the developing murine neocortex: A qualitative and quantitative immunohistochemical analysis

1990 • 109 citations

The regulation of embryonic stem cell differentiation by leukaemia inhibitory factor (LIF)

2001 • 109 citations

The stem cell compartment in human interfollicular epidermis

2002 • 108 citations

Essential role for integrin linked kinase in Akt‐mediated integrin survival signaling in hippocampal neurons

2003 • 104 citations

Localisation of specific heparan sulfate proteoglycans during the proliferative phase of brain development

2003 • 101 citations

Cell–matrix interactions during development and apoptosis of the mouse mammary gland in vivo

2002 • 83 citations

Defective Rac-mediated proliferation and survival after targeted mutation of the β1 integrin cytodomain

2002 • 82 citations

Laminin through its long arm E8 fragment promotes the proliferation and differentiation of murine neuroepithelial cells in vitro

1991 • 78 citations

Disguising adult neural stem cells

2004 • 77 citations

Fractones and other basal laminae in the hypothalamus

2002 • 72 citations

Diversifying Neural Cells through Order of Birth and Asymmetry of Division

2003 • 65 citations

Localized expression of BMP and GDF mRNA in the rodent brain

1999 • 52 citations

Binary cell death decision regulated by unequal partitioning of Numb at mitosis

2002 • 45 citations

Basic fibroblast growth factor upregulates steady-state levels of laminin B1 and B2 chain mRNA in cultured neuroepithelial cells

1991 • 35 citations

Decrease in expression of α5β1 integrin during neuronal differentiation of cortical progenitor cells

2003 • 34 citations

Basic fibroblast growth factor promotes adhesive interactions of neuroepithelial cells from chick neural tube with extracellular matrix proteins in culture

1993 • 33 citations

Antisense knockdown of the β1 integrin subunit in the chicken embryo results in abnormal neural crest cell development

2004 • 28 citations

Radial glia produce and align the ligand fibronectin during neuronal migration in the developing chick brain

2003 • 25 citations

Adhesive Crosstalk in Gastrulation

2003 • 20 citations