Molecular Endocrinology of Hydroxysteroid Dehydrogenases*

Ciba foundation symposium

1964 • 2,217 citations

Steroid Hormone Metabolites Are Barbiturate-Like Modulators of the GABA Receptor

1986 • 2,194 citations

Mineralocorticoid Action: Target Tissue Specificity Is Enzyme, Not Receptor, Mediated

1988 • 1,607 citations

Short-chain dehydrogenases/reductases (SDR)

1995 • 1,228 citations

Neurosteroids: Endogenous bimodal modulators of the GABAA receptor mechanism of action and physiological significance

1992 • 1,098 citations

MINERALOCORTICOID ACTIVITY OF LIQUORICE: 11-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY COMES OF AGE

1987 • 784 citations

Cloning and tissue distribution of the human 1 lβ-hydroxysteroid dehydrogenase type 2 enzyme

1994 • 707 citations

Neurosteroids and GABAA receptor function

1995 • 705 citations

Human hypertension caused by mutations in the kidney isozyme of 11β–hydroxysteroid dehydrogenase

1995 • 621 citations

Male pseudohermaphroditism caused by mutations of testicular 17β–hydroxysteroid dehydrogenase 3

1994 • 561 citations

The Aldo-Keto Reductase Superfamily

1989 • 455 citations

Cloning and Expression of Rat cDNA Encoding Corticosteroid 11β-Dehydrogenase

1989 • 452 citations

The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization.

1991 • 434 citations

Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity

1993 • 433 citations

An Unlikely Sugar Substrate Site in the 1.65 Å Structure of the Human Aldose Reductase Holoenzyme Implicated in Diabetic Complications

1992 • 431 citations

Structure and Expression of a New Complementary DNA Encoding the almost Exclusive 3β-Hydroxysteroid Dehydrogenase/Δ⁵-Δ⁴-lsomerase in Human Adrenals and Gonads

1991 • 357 citations

Full Length cDNA Structure and Deduced Amino Acid Sequence of Human β-Hydroxy-5-Ene Steroid Dehydrogenase

1989 • 314 citations

Licorice Inhibits Corticosteroid 1lβ-Dehydrogenase of Rat Kidney and Liver:In Vivoandin VitroStudies*

1989 • 306 citations

Complete amino acid sequence of human placental 17β‐hydroxysteroid dehydrogenase deduced from cDNA

1988 • 298 citations

REGULATED mRNA STABILITY

1990 • 279 citations

Characterization of cDNAs for Human Estradiol 17β-Dehydrogenase and Assignment of the Gene to Chromosome 17: Evidence of two mRNA Species with Distinct 5′-Termini in Human Placenta

1989 • 275 citations

Purification of a 17β-Hydroxysteroid Dehydrogenase of Human Placenta and Studies on Its Transhydrogenase Function

1962 • 268 citations

Steroid Structure and Androgenic Activity

1973 • 262 citations

Phospholipid bilayers

1988 • 246 citations

NAD(+)-dependent isoform of 11 beta-hydroxysteroid dehydrogenase. Cloning and characterization of cDNA from sheep kidney

1994 • 246 citations

THE ENZYMATIC TRANSFER OF HYDROGEN

1953 • 240 citations

Structure of human estrogenic 17β-hydroxysteroid dehydrogenase at 2.20 å resolution

1995 • 236 citations

Three-dimensional structure of holo 3 alpha,20 beta-hydroxysteroid dehydrogenase: a member of a short-chain dehydrogenase family.

1991 • 232 citations

Importance of estrogen sulfates in breast cancer

1989 • 230 citations

Congenital adrenal hyperplasia due to point mutations in the type II 3β–hydroxysteroid dehydrogenase gene

1992 • 229 citations

Human 3β-Hydroxysteroid Dehydrogenase/ δ5→4Isomerase from Placenta: Expression in Nonsteroidogenic Cells of a Protein that Catalyzes the Dehydrogenation/Isomerization of C21 and C19 Steroids*

1990 • 213 citations

Molecular cloning of a novel widely expressed human 80 kDa 17β-hydroxysteroid dehydrogenase IV

1995 • 211 citations

17 beta-Hydroxysteroid dehydrogenase type 2: chromosomal assignment and progestin regulation of gene expression in human endometrium.

1994 • 209 citations

The structure of a complex of human 17β-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors

1996 • 207 citations

A mutation in the HSD11B2 gene in a family with apparent mineralocorticoid excess.

1995 • 200 citations

Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells

1990 • 200 citations

The refined three-dimensional structure of 3α,20β-hydroxysteroid dehydrogenase and possible roles of the residues conserved in short-chain dehydrogenases

1994 • 199 citations

Molecular genetics and pathophysiology of 17 beta-hydroxysteroid dehydrogenase 3 deficiency

1996 • 188 citations

Purification and properties of a 3α-hydroxysteroid dehydrogenase of rat liver cytosol and its inhibition by anti-inflammatory drugs

1984 • 187 citations

Nucleotide sequence, transcription and deduced function of a gene involved in polyketide antibiotic synthesis in Streptomyces coelicolor

1988 • 178 citations

Substrate Specificity, Gene Structure, and Tissue-specific Distribution of Multiple Human 3α-Hydroxysteroid Dehydrogenases

1995 • 177 citations

Structure of Two in Tandem Human 17β-Hydroxysteroid Dehydrogenase Genes

1990 • 176 citations

Aldose reductase and ϱ‐crystallin belong to the same protein superfamily as aldehyde reductase

1987 • 175 citations

Familial Male Pseudohermaphroditism with Gynecomastia Due to a Testicular 17-Ketosteroid Reductase Defect. I. Studiesin Vivo

1971 • 172 citations

Association between Plasma Level of Growth Hormone and Sex Differentiation of Hepatic Steroid Metabolism in the Rat*

1982 • 171 citations

Expression of 11β-Hydroxysteroid Dehydrogenase Using Recombinant Vaccinia Virus

1990 • 158 citations

Structural similarity of bovine lung prostaglandin F synthase to lens epsilon-crystallin of the European common frog.

1988 • 156 citations

Continuous Infusion of Growth Hormone Feminizes Hepatic Steroid Metabolism in the Rat*

1981 • 156 citations

A MAMMALIAN 3α-HYDROXYSTEROID DEHYDROGENASE

1956 • 152 citations

Site-specific mutagenesis of Drosophila alcohol dehydrogenase: Evidence for involvement of tyrosine-152 and lysine-156 in catalysis

1993 • 151 citations

Cloning and sequencing of the cDNA for rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase

1991 • 148 citations

Immunohistochemical Localization of Aromatase Cytochrome P-450 and Estradiol Dehydrogenase in the Syncytiotrophoblast of the Human Placenta*

1987 • 147 citations

Several homozygous mutations in the gene for 11 beta-hydroxysteroid dehydrogenase type 2 in patients with apparent mineralocorticoid excess.

1995 • 138 citations

Cloning and expression of cDNA of human Δ⁴‐3‐oxosteroid 5β‐reductase and substrate specificity of the expressed enzyme

1994 • 138 citations

Three-dimensional structure of rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily.

1994 • 137 citations

Human carbonyl reductase. Nucleotide sequence analysis of a cDNA and amino acid sequence of the encoded protein.

1988 • 131 citations

Structure of the Human Type II 3β-Hydroxysteroid Dehydrogenase/Δ⁵-Δ⁴Isomerase (3β-HSD) Gene: Adrenal and Gonadal Specificity

1991 • 128 citations

Regulation of sexual differentiation in drug and steroid metabolism

1989 • 124 citations

Porcine 80-kDa Protein Reveals Intrinsic 17β-Hydroxysteroid Dehydrogenase, Fatty Acyl-CoA-hydratase/Dehydrogenase, and Sterol Transfer Activities

1996 • 119 citations

Tyr-179 and Lys-183 are essential for enzymatic activity of 11β-hydroxysteroid dehydrogenase

1992 • 116 citations

Localization of an 11 beta hydroxysteroid dehydrogenase activity to the distal nephron. Evidence for the existence of two species of dehydrogenase in the rat kidney.

1992 • 112 citations

Gene Structure and Chromosomal Localization of the Human HSD11K Gene Encoding the Kidney (Type 2) Isozyme of 11β-Hydroxysteroid Dehydrogenase

1995 • 111 citations

cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family

1993 • 109 citations

Molecular Cloning and Characterization of Mouse Estradiol 17β-Dehydrogenase (A-Specific), a Member of the Aldoketoreductase Family

1995 • 107 citations

Purification and structural characterization of placental NAD+-linked 15-hydroxyprostaglandin dehydrogenase. The primary structure reveals the enzyme to belong to the short-chain alcohol dehydrogenase family

1990 • 105 citations

Studies on pig muscle aldose reductase. Kinetic mechanism and evidence for a slow conformational change upon coenzyme binding.

1992 • 105 citations

The Intrarenal Localization of Mineralocorticoid Receptors and 11β-Dehydrogenase: Immunocytochemical Studies

1989 • 105 citations

Corticosteroids, receptors, and the organ‐specific functions of 11 β ‐hydroxysteroid dehydrogenase

1991 • 104 citations

Site-directed mutagenesis of the conserved tyrosine 151 of human placental NAD+-dependent 15-hydroxyprostaglandin dehydrogenase yields a catalytically inactive enzyme

1991 • 102 citations

Cloning and Sequence Determination of Human Placental Aldose Reductase Gene

1989 • 101 citations

Human placental 3β-hydroxy-5-ene-steroid dehydrogenase and steroid 5 → 4-ene-isomerase: Purification from microsomes, substrate kinetics, and inhibition by product steroids

1988 • 100 citations

Regulation of the Gene for Estrogenic 17-Ketosteroid Reductase Lying on Chromosome 17cen→q25

1989 • 99 citations

Molecular basis of congenital adrenal hyperplasia due to 3 beta-hydroxysteroid dehydrogenase deficiency.

1993 • 99 citations

The short-chain alcohol dehydrogenase superfamily: Variations on a common theme

1994 • 98 citations

Multihormonal Regulation of the Estrogen Receptor in Rat Liver*

1981 • 98 citations

Molecular cloning of two human liver 3 α-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder

1994 • 97 citations

Pig testicular 20 beta-hydroxysteroid dehydrogenase exhibits carbonyl reductase-like structure and activity. cDNA cloning of pig testicular 20 beta-hydroxysteroid dehydrogenase.

1992 • 95 citations

Structure and function of the hepatic form of 11 beta-hydroxysteroid dehydrogenase in the squirrel monkey, an animal model of glucocorticoid resistance.

1993 • 92 citations

THE ENZYMATIC TRANSFER OF HYDROGEN

1953 • 91 citations

Structure of 3α-Hydroxysteroid/Dihydrodiol Dehydrogenase Complexed with NADP⁺

1996 • 91 citations

Human Aldose Reductase: Rate Constants for a Mechanism Including Interconversion of Ternary Complexes by Recombinant Wild-Type Enzyme

1995 • 90 citations

Structure and tissue-specific expression of a novel member of the rat 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) family. The exclusive 3 beta-HSD gene expression in the skin.

1993 • 88 citations

Molecular cloning of testicular 20.alpha.-hydroxysteroid dehydrogenase: Identity with aldose reductase

1993 • 87 citations

Purification and Properties of Multiple Forms of Dihydrodiol Dehydrogenase from Human Liver1

1990 • 87 citations

Molecular Cloning of Human Type 3 3α-Hydroxysteroid Dehydrogenase That Differs from 20α-Hydroxysteroid Dehydrogenase by Seven Amino Acids

1996 • 85 citations

Characterization of 11 β-Hydroxysteroid Dehydrogenase Gene Expression: Identification of Multiple Unique Forms of Messenger Ribonucleic Acid in the Rat Kidney

1990 • 85 citations

Prokaryotic 20β-hydroxysteroid dehydrogenase is an enzyme of the ‘short-chain, non-metalloenzyme’ alcohol dehydrogenase type

1990 • 85 citations

Steroid Modulation of the GABA _A Receptor Complex: Electrophysiological Studies

2007 • 83 citations

Compartmentalization of type 117β-hydroxysteroid oxidoreductase in the human ovary

1994 • 82 citations

Molecular cloning, cDNA structure and predicted amino acid sequence of bovine 3β‐hydroxy‐5‐ene steroid dehydrogenase/Δ⁵‐Δ⁴ isomerase

1989 • 81 citations

Molecular structure of rat hepatic 3 alpha-hydroxysteroid dehydrogenase. A member of the oxidoreductase gene family

1991 • 81 citations

Site-directed mutagenesis of the putative active site of human 17β-hydroxysteroid dehydrogenase type 1

1994 • 79 citations

Direct stimulation of ovarian progesterone-metabolizing enzyme by gonadotropin-releasing hormone in cultured granulosa cells.

1981 • 79 citations

Studies on the Mechanism of 3α-Androstanediol-Induced Growth of the Dog Prostate*

1978 • 78 citations

Structure of the human aldose reductase gene.

1991 • 78 citations

11 Structure, regulation and role of 3β-hydroxysteroid dehydrogenase, 17β-hydroxysteroid dehydrogenase and aromatase enzymes in the formation of sex steroids in classical and peripheral intracrine tissues

1994 • 78 citations

MRNA stability: in trans-it

1992 • 78 citations

Overexpression and mutagenesis of the cDNA for rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase. Role of cysteines and tyrosines in catalysis.

1994 • 76 citations

17 -Hydroxysteroid dehydrogenase: inhibitors and inhibitor design

1996 • 75 citations

A novel type of crystallin in the frog eye lens

1984 • 75 citations

The kinetic mechanism catalysed by homogeneous rat liver 3α-hydroxysteroid dehydrogenase. Evidence for binary and ternary dead-end complexes containing non-steroidal anti-inflammatory drugs

1991 • 73 citations

A growth factor-repressible gene associated with protein kinase C-mediated inhibition of adipocyte differentiation.

1988 • 73 citations

Partial characterization of the cytosol 3α-hydroxysteroid:NAD(P)⁺ oxidoreductase of rat ventral prostate

1975 • 73 citations

Molecular basis of human 3β-hydroxysteroid dehydrogenase deficiency

1995 • 72 citations

Mechanistic basis for nonlinear kinetics of aldehyde reduction catalyzed by aldose reductase

1990 • 68 citations

Molecular Cloning and Expression of Rat Liver 3α-Hydroxysteroid Dehydrogenase

1991 • 66 citations

The Human Type II 17β-Hydroxysteroid Dehydrogenase Gene Encodes Two Alternatively Spliced mRNA Species

1995 • 65 citations

Human placental estradiol 17.beta.-dehydrogenase: sequence of a histidine-bearing peptide inthe catalytic region

1986 • 64 citations

Immunohistochemical localization of 17 beta-hydroxysteroid dehydrogenase in the human endometrium during the menstrual cycle.

1991 • 64 citations

Characterization of the structure-activity relationships of rat types I and II 3 beta-hydroxysteroid dehydrogenase/delta 5 -delta 4 isomerase by site-directed mutagenesis and expression in HeLa cells

1991 • 63 citations

Differential estrogen substrate specificities for transiently expressed human placental 17 beta-hydroxysteroid dehydrogenase and an endogenous enzyme expressed in cultured COS-m6 cells.

1993 • 62 citations

Steroidal regulation of oestradiol-17β dehydrogenase activity of the human breast cancer cell line MCF-7

1988 • 62 citations

Molecular cloning of cDNA for rat ovarian 20 α-hydroxysteroid dehydrogenase (HSD1)

1994 • 61 citations

No evidence of mutations in the genes for type I and type II 3 beta-hydroxysteroid dehydrogenase (3 beta HSD) in nonclassical 3 beta HSD deficiency.

1994 • 61 citations

Characterization of macaque 3β-hydroxy-5-ene steroid dehydrogenase/Δ5-Δ4 isomerase: structure and expression in steroidogenic and peripheral tissues in primate

1991 • 60 citations

Induction of 20α-hydroxysteroid dehydrogenase in rat corpora lutea of pregnancy by prostaglandin F2α

1974 • 60 citations

Stereospecificity of Hydrogen Transfer by Pyridine Nucleotide-linked Hydroxysteroid Dehydrogenases

1960 • 60 citations

Regulation of 3 beta-hydroxysteroid dehydrogenase and 17 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid levels by cyclic adenosine 3',5'-monophosphate and phorbol myristate acetate in human choriocarcinoma cells.

1993 • 59 citations

The R337C mutation generates a high Km 11 beta-hydroxysteroid dehydrogenase type II enzyme in a family with apparent mineralocorticoid excess.

1995 • 59 citations

A soluble 17β-hydroxysteroid dehydrogenase from human placenta. The binding of pyridine nucleotides and steroids

1969 • 57 citations

Purification and Properties of NADP‐Dependent 17β‐Hydroxysteroid Dehydrogenase Solubilized from Porcine‐Testicular Microsomal Fraction

1974 • 56 citations

Mechanism of inhibition of 3α,20β-hydroxysteroid dehydrogenaseby a licorice-derived steroidal inhibitor

1994 • 55 citations

Electrophoretic and immunochemical characterization of 3α-hydroxysteroid/dihydrodiol dehydrogenases of rat tissues

1988 • 55 citations

Tissue-specific expression of an 11 beta-hydroxysteroid dehydrogenase with a truncated N-terminal domain. A potential mechanism for differential intracellular localization within mineralocorticoid target cells.

1992 • 54 citations

The molecular biology of androgenic 17β-hydroxysteroid dehydrogenases

1995 • 53 citations

Detection and functional characterization of the novel missense mutation Y254D in type II 3 beta-hydroxysteroid dehydrogenase (3 beta HSD) gene of a female patient with nonsalt-losing 3 beta HSD deficiency.

1994 • 53 citations

Regulation of mRNA Expression of 3β-Hydroxy-5-Ene Steroid Dehydrogenase in Porcine Granulosa Cells in Culture: A Role for the Protein Kinase-C Pathway

1990 • 53 citations

Human Aldose Reductase: pK of Tyrosine 48 Reveals the Preferred Ionization State for Catalysis and Inhibition

1995 • 52 citations

Molecular cloning and expression of an abundant rabbit ovarian protein with 20 alpha-hydroxysteroid dehydrogenase activity.

1993 • 51 citations

17β-Hydroxysteroid dehydrogenase: isozymes and mutations

1995 • 51 citations

Unusual evolution of 11β‐ and 17β‐hydroxysteroid and retinol dehydrogenases

1996 • 50 citations

Molecular basis of congenital adrenal hyperplasia in two siblings with classical nonsalt-losing 3 beta-hydroxysteroid dehydrogenase deficiency.

1994 • 48 citations

The Formation of 5α-Androstane-3α,17β-diol by Dog Prostate

1976 • 48 citations

Molecular cloning and sequence analysis of cDNA encoding δ⁴-3-ketosteroid 5β-reductase of rat liver

1991 • 47 citations

Expression of liver-specific member of the 3 beta-hydroxysteroid dehydrogenase family, an isoform possessing an almost exclusive 3-ketosteroid reductase activity.

1992 • 47 citations

Purification and Properties of Rat Ovarian 20 α-Hydroxysteroid Dehydrogenase

1961 • 46 citations

Genealogy of regulation of human sex and adrenal function, prostaglandin action, snapdragon and petunia flower colors, antibiotics, and nitrogen fixation: functional diversity from two ancestral dehydrogenases

1991 • 46 citations

Isolation and sequencing of a complementary deoxyribonucleic acid clone encoding human placental 173-estradiol dehydrogenase: Identification of the putative cofactor binding site

1989 • 46 citations

Synthesis of 16alpha-bromoacetoxyestradiol 3-methyl ether and study of the steroid binding site of human placental estradiol 17beta-dehydrogenase.

1975 • 44 citations

Reaction mechanism and stereospecificity of 20 β-hydroxysteroid dehydrogenase

1968 • 43 citations

11β-Hydroxysteroid dehydrogenase activity and corticosteroid hormone action

1994 • 42 citations

EVIDENCE FOR THE REGULATION OF 3β-HYDROXYSTEROID DEHYDROGENASE MESSENGER RNA BY HUMAN CHORIONIC GONADOTROPHIN IN LUTEINIZED PORCINE GRANULOSA CELLS

1990 • 42 citations

Genomic organization and DNA sequences of human 17beta-hydroxysteroid dehydrogenase genes and flanking regions. Localization of multiple Alu sequences and putative cis-acting elements

1992 • 42 citations

Enzymatic mechanisms of hormone metabolism. I. Oxidation-reduction of the steroid nucleus.

1956 • 40 citations

The organelles containing porcine 17 beta-estradiol dehydrogenase are peroxisomes.

1995 • 40 citations

Reaction Mechanism of 17β-Estradiol Dehydrogenase Determined by Equilibrium Rate Exchange

1971 • 39 citations

Regulation of oestradiol 17β hydroxysteroid dehydrogenase in breast tissues: The role of growth factors

1991 • 39 citations

Potentiation of Glucocorticoid Activity by 5β-Dihydrocortisol: Its Role in Glaucoma

1983 • 39 citations

Isolation and Characterization of a Rat Luteal cDNA Encoding 20α-Hydroxysteroid Dehydrogenase

1994 • 37 citations

Congenital adrenal hyperplasia caused by a novel homozygous frameshift mutation 273ΔAA in type II 3β-hydroxysteroid dehydrogenase gene (HSD3B2) in three male patients of Afghan/Pakistani origin

1994 • 36 citations

Changes in dihydrotestosterone metabolism and the development of benign prostatic hyperplasia in the aging beagle

1983 • 36 citations

Ribitol dehydrogenase of Klebsiella aerogenes. Sequence and properties of wild-type and mutant strains

1985 • 35 citations

Isozymes of 11β-hydroxysteroid dehydrogenase: Which enzyme endows mineralocorticoid specificity?

1994 • 33 citations

Further studies of rat ovarian 20α-hydroxysteroid dehydrogenase

1966 • 33 citations

Human 17β-hydroxysteroid dehydrogenase: overproduction using a baculovirus expression system and characterization

1994 • 32 citations

Characterization of 17 beta-hydroxysteroid dehydrogenase IV.

1996 • 31 citations

Regulation of 3β-Hydroxysteroid Dehydrogenase/Δ_5→4- Isomerase Expression by Adrenocorticotropin in Bovine Adrenocortical Cells*

1991 • 31 citations

Human Aldose Reductase: Subtle Effects Revealed by Rapid Kinetic Studies of the C298A Mutant Enzyme

1995 • 31 citations

Identification and characterization of the G15D mutation found in a male patient with 3.beta.-hydroxysteroid dehydrogenase (3.beta.-HSD) deficiency: alteration of the putative NAD-binding domain of Type II 3.beta.-HSD

1995 • 31 citations

Inactivation of human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase with active site-directed 17 beta-propynyl-substituted progestin analogs.

1982 • 30 citations

Licorice, computer-based analyses of dehydrogenase sequences, and the regulation of steroid and prostaglandin action

1991 • 30 citations

Nonsalt-losing male pseudohermaphroditism due to the novel homozygous N100S mutation in the type II 3 beta-hydroxysteroid dehydrogenase gene.

1995 • 30 citations

Isolation and characterization of cDNA clones encoding aldose reductase

1989 • 28 citations

The gene for 17beta-hydroxysteroid dehydrogenase maps to human chromosome 17, bands q12?q21, and shows an RFLP with ScaI

1990 • 28 citations

Cloning, sequencing, and functional analysis of the 5'-flanking region of the rat 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase gene.

1995 • 28 citations

Characterization of the 3α-hydroxysteroid dehydrogenase of dog prostate

1977 • 28 citations

Genomic organization and chromosomal localization of a novel human hepatic dihydrodiol dehydrogenase with high affinity bile acid binding.

1994 • 27 citations

The murine 3β-hydroxysteroid dehydrogenase multigene family: Structure, function and tissue-specific expression

1995 • 26 citations

Immunohistochemical Localization of 11-Hydroxysteroid Dehydrogenase in Rat Kidney with a Monoclonal Antibody

1989 • 26 citations

Termination of Early Pregnancy by the 3β-Hydroxysteroid Dehydrogenase Inhibitor Epostane

1988 • 26 citations

Purification of rat ovary 20α-hydroxysteroid dehydrogenase by affinity chromatography

1979 • 25 citations

Overlapping cis-acting elements located in the first intron of the gene for type I 3 beta-hydroxysteroid dehydrogenase modulate its transcriptional activity.

1995 • 24 citations

Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization

1995 • 21 citations

Molecular cloning and expression of an abundant rabbit ovarian protein with 20 alpha-hydroxysteroid dehydrogenase activity.

1993 • 21 citations

Reaction mechanism of 20β-hydroxysteroid dehydrogenase determined by equilibrium rate exchange

1970 • 21 citations

Rat dihydrodiol dehydrogenase: complexity of gene structure and tissue-specific and sexually dimorphic gene expression.

1994 • 20 citations

Intraocular hypotensive effect of a topically applied cortisol metabolite: 3 alpha, 5 beta-tetrahydrocortisol.

1987 • 20 citations

Genetic analysis of 11β-hydroxysteroid dehydrogenase

1994 • 20 citations

Mechanism Based Inhibition of Hydroxysteroid Dehydrogenases

1991 • 17 citations

Rat Hepatic 3α-Hydroxysteroid Dehydrogenase: Expression of cDNA and Physiological Function in Bile Acid Biosynthetic Pathway

1994 • 17 citations

Mechanism of the bond forming events in pyridine nucleotide linked oxidoreductases. Epoxide inhibitors of lactic dehydrogenase and β-hydroxybutyrate dehydrogenase

1975 • 15 citations

Stereochemistry of hydrogen transfer by rat ovary 20α-hydroxy steroid dehydrogenase

1970 • 15 citations

Regulation of Adrenal 3β-Hydroxysteroid Dehydrogenase/Δ⁵-δ⁴-Isomerase Expression and Activity by Adrenocorticotropin and Corticosterone in the Rat*

1991 • 14 citations

Regulation of 3 beta-hydroxysteroid dehydrogenase expression in human adrenocortical H295R cells.

1996 • 13 citations

Evidence that enzyme-generated aromatic Michael acceptors covalently modify the nucleotide-binding site of 3α-hydroxysteroid dehydrogenase

1990 • 13 citations

Hormonal regulation of 3α-hydroxysteroid/dihydrodiol dehydrogenase in rat liver cytosol

1992 • 12 citations

Hydroxysteroid dehydrogenases. New drug targets of the aldo-keto reductase superfamily.

1997 • 4 citations

Deleted Work

1955 • 0 citations