Isozymes of 11β-hydroxysteroid dehydrogenase: Which enzyme endows mineralocorticoid specificity?

Mineralocorticoid Action: Target Tissue Specificity Is Enzyme, Not Receptor, Mediated

1988 • 1,607 citations

LOCALISATION OF 11β-HYDROXYSTEROID DEHYDROGENASE—TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR

1988 • 1,047 citations

Glucocorticoid exposure in utero: new model for adult hypertension

1993 • 873 citations

MINERALOCORTICOID ACTIVITY OF LIQUORICE: 11-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY COMES OF AGE

1987 • 784 citations

Dysfunction of placental glucocorticoid barrier: link between fetal environment and adult hypertension?

1993 • 554 citations

Renal mineralocorticoid receptors and hippocampal corticosterone-binding species have identical intrinsic steroid specificity.

1983 • 515 citations

Cloning and Expression of Rat cDNA Encoding Corticosteroid 11β-Dehydrogenase

1989 • 452 citations

Complete amino acid sequence of human placental 17β‐hydroxysteroid dehydrogenase deduced from cDNA

1988 • 298 citations

Potentiation of hydrocortisone activity in skin by glycyrrhetinic acid

1990 • 200 citations

Nucleotide sequence, transcription and deduced function of a gene involved in polyketide antibiotic synthesis in Streptomyces coelicolor

1988 • 178 citations

Expression of 11β-Hydroxysteroid Dehydrogenase Using Recombinant Vaccinia Virus

1990 • 158 citations

Human carbonyl reductase. Nucleotide sequence analysis of a cDNA and amino acid sequence of the encoded protein.

1988 • 131 citations

11β-Hydroxysteroid dehydrogenase: Fact or fancy?

1984 • 129 citations

llβ-Hydroxysteroid Dehydrogenase Activity in the Renal Target Cells of Aldosterone*

1991 • 121 citations

Localization of an 11 beta hydroxysteroid dehydrogenase activity to the distal nephron. Evidence for the existence of two species of dehydrogenase in the rat kidney.

1992 • 112 citations

Corticosteroid llβ-Dehydrogenase of Rat Tissues: Immunological Studies

1990 • 108 citations

Purification and structural characterization of placental NAD+-linked 15-hydroxyprostaglandin dehydrogenase. The primary structure reveals the enzyme to belong to the short-chain alcohol dehydrogenase family

1990 • 105 citations

Regional Distribution of 1 β-Hydroxysteroid Dehydrogenase in Rat Brain*

1991 • 105 citations

The Intrarenal Localization of Mineralocorticoid Receptors and 11β-Dehydrogenase: Immunocytochemical Studies

1989 • 105 citations

Corticosteroids, receptors, and the organ‐specific functions of 11 β ‐hydroxysteroid dehydrogenase

1991 • 104 citations

11β-Hydroxysteroid dehydrogenase and the short-chain alcohol dehydrogenase (SCAD) superfamily

1992 • 100 citations

Apparent mineralocorticoid excess, pseudohypoaldosteronism, and urinary electrolyte excretion: toward a redefinition of mineralocorticoid action

1990 • 100 citations

Pig testicular 20 beta-hydroxysteroid dehydrogenase exhibits carbonyl reductase-like structure and activity. cDNA cloning of pig testicular 20 beta-hydroxysteroid dehydrogenase.

1992 • 95 citations

Tissue-specific distribution of the NAD(+)-dependent isoform of 11 beta-hydroxysteroid dehydrogenase.

1992 • 93 citations

Regulation of Steroid Hormone Action in Target Cells by Specific Hormone-Inactivating Enzymes

1992 • 89 citations

Characterization of 11 β-Hydroxysteroid Dehydrogenase Gene Expression: Identification of Multiple Unique Forms of Messenger Ribonucleic Acid in the Rat Kidney

1990 • 85 citations

Prokaryotic 20β-hydroxysteroid dehydrogenase is an enzyme of the ‘short-chain, non-metalloenzyme’ alcohol dehydrogenase type

1990 • 85 citations

Distribution of 11 beta-hydroxysteroid dehydrogenase along the rabbit nephron.

1990 • 80 citations

Defective ring A reduction of cortisol as the major metabolic error in the syndrome of apparent mineralocorticoid excess.

1992 • 78 citations

A growth factor-repressible gene associated with protein kinase C-mediated inhibition of adipocyte differentiation.

1988 • 73 citations

Detection of glycyrrhetinic acid-like factors (GALFs) in human urine.

1992 • 60 citations

Localization of an 11 beta hydroxysteroid dehydrogenase activity to the distal nephron. Evidence for the existence of two species of dehydrogenase in the rat kidney

1992 • 57 citations

Tissue-specific expression of an 11 beta-hydroxysteroid dehydrogenase with a truncated N-terminal domain. A potential mechanism for differential intracellular localization within mineralocorticoid target cells.

1992 • 54 citations

Differential promoter usage by the rat 11 beta-hydroxysteroid dehydrogenase gene.

1992 • 49 citations

Bile acids and their amidates inhibit 11?-hydroxysteroid dehydrogenase obtained from rat kidney

1991 • 46 citations

Metabolism of Dexamethasone: Sites and Activity in Mammalian Tissues

1993 • 45 citations

Characterization of 11β-HSD1B gene expression and enzymatic activity

1993 • 45 citations

Mineralocorticoid Receptors in the Rat Lung*

1981 • 40 citations

THE HORMONAL REGULATION OF HEPATIC MICROSOMAL 11β-HYDROXYSTEROID DEHYDROGENASE ACTIVITY IN THE RAT

1978 • 40 citations

Tissue-specific distribution of the NAD(+)-dependent isoform of 11 beta- hydroxysteroid dehydrogenase

1992 • 37 citations

The 11β-hydroxysteroid dehydrogenase inhibitor glycyrrhetinic acid affects corticosteroid feedback regulation of hypothalamic corticotrophin-releasing peptides in rats

1993 • 36 citations

Ribitol dehydrogenase of Klebsiella aerogenes. Sequence and properties of wild-type and mutant strains

1985 • 35 citations

Multiple patterns of 11β-hydroxysteroid dehydrogenase catalytic activity along the mammalian nephron

1992 • 34 citations

Transcripts originating in intron 1 of the HSD11 (11 beta-hydroxysteroid dehydrogenase) gene encode a truncated polypeptide that is enzymatically inactive.

1993 • 34 citations

Heterogeneity of 11β-hydroxysteroid dehydrogenase in rat tissues

1991 • 33 citations

Defective ring A reduction of cortisol as the major metabolic error in the syndrome of apparent mineralocorticoid excess

1992 • 32 citations

Differential promoter usage by the rat 11 beta-hydroxysteroid dehydrogenase gene

1992 • 30 citations

Renal 11β-hydroxysteroid dehydrogenase activity: Effects of age, sex and altered hormonal status

1991 • 26 citations

ORGAN-SPECIFIC ONTOGENESES OF STEROID HORMONE METABOLIZING ENZYME ACTIVITIES IN THE RAT

1975 • 22 citations

Transcripts originating in intron 1 of the HSD11 (11 beta- hydroxysteroid dehydrogenase) gene encode a truncated polypeptide that is enzymatically inactive

1993 • 16 citations

A possible defect in the inter-conversion between cortisone and cortisol in prepubertal patients with congenital adrenal hyperplasia receiving cortisone acetate therapy

1991 • 11 citations

CORTISOL UTILIZATION BY SALIVARY GLAND, KIDNEY AND ADRENAL CORTEX

1970 • 10 citations

Study of the ductal epithelial cell component of human labial salivary glands in vitro.

1984 • 6 citations

Radioenzymaticassay for Some Substrates and Inhibitors of Human Placental 11-Hydroxysteroid Dehydrogenase

1982 • 3 citations