Site-directed mutagenesis of the putative active site of human 17β-hydroxysteroid dehydrogenase type 1

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Prediction of the occurrence of the ADP-binding βαβ-fold in proteins, using an amino acid sequence fingerprint

1986 • 1,172 citations

Comparison of super-secondary structures in proteins

1973 • 885 citations

The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization.

1991 • 434 citations

Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity

1993 • 433 citations

Complete amino acid sequence of human placental 17β‐hydroxysteroid dehydrogenase deduced from cDNA

1988 • 298 citations

Characterization of cDNAs for Human Estradiol 17β-Dehydrogenase and Assignment of the Gene to Chromosome 17: Evidence of two mRNA Species with Distinct 5′-Termini in Human Placenta

1989 • 275 citations

Three-dimensional structure of holo 3 alpha,20 beta-hydroxysteroid dehydrogenase: a member of a short-chain dehydrogenase family.

1991 • 232 citations

Distribution of 17β-hydroxysteroid dehydrogenase gene expression and activity in rat and human tissues

1992 • 228 citations

Estradiol and 20α-Dihydroprogesterone Dehydrogenase Activities in Human Endometrium During the Menstrual Cycle

1974 • 177 citations

Structure of Two in Tandem Human 17β-Hydroxysteroid Dehydrogenase Genes

1990 • 176 citations

Human Placental Estradiol-17β Dehydrogenase

1958 • 163 citations

Subunit identity of the dimeric 17 beta-hydroxysteroid dehydrogenase from human placenta.

1992 • 118 citations

Immunological analysis of 17β‐hydroxysteroid dehydrogenase in benign and malignant human breast tissue

1992 • 116 citations

Glucitol-specific enzymes of the phosphotransferase system in Escherichia coli. Nucleotide sequence of the gut operon.

1987 • 101 citations

11β-Hydroxysteroid dehydrogenase and the short-chain alcohol dehydrogenase (SCAD) superfamily

1992 • 100 citations

Convergence of active center geometries

1977 • 89 citations

17 beta-hydroxysteroid dehydrogenase gene expression in human breast cancer cells: regulation of expression by a progestin.

1992 • 77 citations

Complete amino acid sequence of glucose dehydrogenase from Bacillus megaterium

1984 • 75 citations

Endogenous steroids in the pathophysiology of breast cancer

1989 • 67 citations

Human placental estradiol 17.beta.-dehydrogenase: sequence of a histidine-bearing peptide inthe catalytic region

1986 • 64 citations

Differential estrogen substrate specificities for transiently expressed human placental 17 beta-hydroxysteroid dehydrogenase and an endogenous enzyme expressed in cultured COS-m6 cells.

1993 • 62 citations

Amino acid composition and subunit structure. Human placental 17β-estradiol dehydrogenase

1972 • 60 citations

Human familial and sporadic breast cancer: analysis of the coding regions of the 17?-hydroxysteroid dehydrogenase 2 gene (EDH17B2) using a single-strand conformation polymorphism assay

1994 • 59 citations

Rat acid phosphatase: overexpression of active, secreted enzyme by recombinant baculovirus-infected insect cells, molecular properties, and crystallization.

1993 • 47 citations

Immunological measurement of human 17β-hydroxysteroid dehydrogenase

1990 • 41 citations

Some new developments in the knowledge of human placental estradiol-17β dehydrogenase

1977 • 40 citations

Detection of polymorphisms in the estradiol 17β-hydroxysteroid dehydrogenase II gene at the EDH17B2 locus on 17q11–q21

1993 • 34 citations

Human placental 17β‐oestradiol dehydrogenase. Sequence of a tryptic peptide containing an essential cysteine

1973 • 32 citations

Human placental estradiol 17.beta.-dehydrogenase: evidence for inverted substrate orientation ("wrong-way" binding) at the active site

1988 • 31 citations

The relationship between 17β hydroxysteroid dehydrogenase and breast tumour site and size

1985 • 29 citations

Estrogen Regulation of Protein Synthesis and Cell Growth in Human Breast Cancer

1989 • 28 citations

Metabolism of [3H]oestradiol in vivo by normal breast and tumour tissue in postmenopausal women

1986 • 27 citations

Human placental estradiol 17 beta-dehydrogenase. Identification of a single histidine residue affinity-labeled by both 3-bromoacetoxyestrone and 12 beta-bromoacetoxy-4-estrene-3,17-dione.

1983 • 22 citations

Time-resolved immunofluorometric assay of 17 beta-hydroxysteroid dehydrogenase in plasma

1991 • 14 citations

Estradiol 17β-dehydrogenase: full enzymatic activity in the absence of zinc

1991 • 7 citations