Impaired inflammatory response and increased oxidative stress and neurodegeneration after brain injury in interleukin-6-deficient mice

Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals

1985 • 1,042 citations

Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function

1999 • 830 citations

Cytokines and the nervous system I: expression and recognition

1995 • 745 citations

On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases

1989 • 692 citations

Mitochondrial dysfunction in neurodegenerative diseases

1998 • 606 citations

Interleukin-6 (IL-6)—A molecule with both beneficial and destructive potentials

1997 • 482 citations

IL-6-Deficient Mice Are Resistant to Experimental Autoimmune Encephalomyelitis: Roles of IL-6 in the Activation and Differentiation of Autoreactive T Cells

1998 • 448 citations

Physiological and pathological roles of interleukin-6 in the central nervous system

1997 • 403 citations

An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration

1999 • 393 citations

The role of tumour necrosis factor, interleukin 6, interferon-γ and inducible nitric oxide synthase in the development and pathology of the nervous system

1998 • 377 citations

Cytokine Actions in the Central Nervous System

1998 • 373 citations

Inflammatory cytokines IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha impart neuroprotection to an excitotoxin through distinct pathways.

1999 • 332 citations

Accelerated Nerve Regeneration in Mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma.

1996 • 321 citations

IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis

1998 • 307 citations

Enhanced Sensitivity to Oxidative Stress in Cultured Embryonic Cells from Transgenic Mice Deficient in Metallothionein I and II Genes

1995 • 302 citations

Impaired neuroglial activation in interleukin-6 deficient mice

1997 • 284 citations

Inflammatory Cytokines IL-1α, IL-1β, IL-6, and TNF-α Impart Neuroprotection to an Excitotoxin Through Distinct Pathways

1999 • 272 citations

Metallothionein protects against the cytotoxic and DNA-damaging effects of nitric oxide.

1995 • 243 citations

Interleukin-6 released in human cerebrospinal fluid following traumatic brain injury may trigger nerve growth factor production in astrocytes

1996 • 231 citations

Yeast and mammalian metallothioneins functionally substitute for yeast copper-zinc superoxide dismutase.

1993 • 230 citations

Oxidative stress and neurodegenerative disorders

1998 • 203 citations

Hypoxia/reoxygenation-mediated induction of astrocyte interleukin 6: a paracrine mechanism potentially enhancing neuron survival.

1994 • 193 citations

Strongly compromised inflammatory response to brain injury in interleukin-6-deficient mice

1999 • 189 citations

Evidence for a protective role of metallothionein-1 in focal cerebral ischemia

1999 • 175 citations

Interleukin-6 protects cultured rat hippocampal neurons against glutamate-induced cell death

1994 • 167 citations

Role of interleukin‐6 and soluble IL‐6 receptor in region‐specific induction of astrocytic differentiation and neurotrophin expression

1999 • 165 citations

CNS Wound Healing Is Severely Depressed in Metallothionein I- and II-Deficient Mice

1999 • 156 citations

Transgenic Mice That Overexpress Metallothionein-I Are Protected from Cadmium Lethality and Hepatotoxicity

1995 • 156 citations

Interleukin‐6 functions in autoimmune encephalomyelitis: a study in gene‐targeted mice

1998 • 156 citations

Local infusion of interleukin-6 attenuates the neurotoxic effects of NMDA on rat striatal cholinergic neurons

1992 • 154 citations

Interleukin-6 functions in autoimmune encephalomyelitis: a study in gene-targeted mice

1998 • 143 citations

Role of interleukin-6 and soluble IL-6 receptor in region-specific induction of astrocytic differentiation and neurotrophin expression

1999 • 140 citations

Enhanced seizures and hippocampal neurodegeneration following kainic acid‐induced seizures in metallothionein‐I + II‐deficient mice

2000 • 136 citations

Nature of the Retrograde Signal from Injured Nerves that Induces Interleukin-6 mRNA in Neurons

1999 • 133 citations

Metallothioneins and Cell Death by Anticancer Drugs

1995 • 119 citations

Stimulation of the human intercellular adhesion molecule-1 promoter by interleukin-6 and interferon-gamma involves binding of distinct factors to a palindromic response element.

1994 • 118 citations

The protein thiol metallothionein as an antioxidant and protectant against antineoplastic drugs

1998 • 114 citations

Oxidized lipoproteins may play a role in neuronal cell death in Alzheimer disease

1998 • 104 citations

Metallothionein protects DNA from copper-induced but not iron-induced cleavage in vitro

1995 • 100 citations

Production of Monocyte Chemotactic Protein‐1 By Rat Brain Macrophages

1996 • 95 citations

Characterization of Metallothionein-I-Transgenic Mice

1995 • 75 citations

Transgenic expression of interleukin 6 in the central nervous system regulates brain metallothionein-I and -III expression in mice

1997 • 75 citations

Astrocytic functions and physiological reactions to injury: the potential to induce and/or exacerbate neuronal dysfunction--a forum position paper.

1998 • 72 citations

Development of a Competitive Double Antibody Radioimmunoassay for Rat Metallothionein

1993 • 71 citations

Impaired Inflammatory Response to Glial Cell Death in Genetically Metallothionein-I- and -II-Deficient Mice

1999 • 61 citations

Metallothionein (MT) isoforms in the central nervous system (CNS): regional and cell-specific distribution and potential functions as an antioxidant.

1998 • 56 citations

REVIEW ■ : Activation of Microglia: A Dangerous Interlude in Immune Function in the Brain

1996 • 51 citations

Overexpression of interleukin-6 in the central nervous system of transgenic mice increases central but not systemic proinflammatory cytokine production

1996 • 50 citations

IL-6 Deficiency Leads to Reduced Metallothionein-I+II Expression and Increased Oxidative Stress in the Brain Stem after 6-Aminonicotinamide Treatment

2000 • 50 citations

Protective effect of interleukin-6 against the death of PC12 cells caused by serum deprivation or by the addition of a calcium ionophore

1996 • 44 citations

Increased astrocytic expression of metallothioneins I+II in brainstem of adult rats treated with 6-aminonicotinamide

1997 • 37 citations

Effect of nitric oxide synthesis inhibition on mouse liver and brain metallothionein expression

1998 • 31 citations

Effect of Interleukin-6 and Tumor Necrosis Factor-α on GABA Release from Mediobasal Hypothalamus and Posterior Pituitary

2000 • 30 citations

Endotoxin and intracerebroventricular injection of IL-1 and IL-6 induce rat brain metallothionein-I and -II

1998 • 25 citations

Protection by Zinc-Metallothionein (ZnMT) against Cadmium-Metallothionein-Induced Nephrotoxicity

1995 • 21 citations

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