Inflammatory cytokines IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha impart neuroprotection to an excitotoxin through distinct pathways.

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1987 • 64,270 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

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1996 • 1,620 citations

TUMOR NECROSIS FACTOR: A Pleiotropic Cytokine and Therapuetic Target

1994 • 1,047 citations

The Diversity of Neuronal Nicotinic Acetylcholine Receptors

1993 • 1,040 citations

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1996 • 947 citations

Cytokines and the nervous system II: actions and mechanisms of action

1995 • 928 citations

Interleukin-1, Interleukin-1 Receptors and Interleukin-1 Receptor Antagonist

1998 • 761 citations

Cytokines and the nervous system I: expression and recognition

1995 • 745 citations

Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis

1994 • 672 citations

Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.

1995 • 632 citations

Activation of NF-?B protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration

1997 • 572 citations

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1993 • 561 citations

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1992 • 547 citations

A neuromodulatory role of interleukin-1β in the hippocampus

1998 • 481 citations

Cerebral Interleukin-6 is Neuroprotective during Permanent Focal Cerebral Ischemia in the Rat

1998 • 417 citations

Physiological and pathological roles of interleukin-6 in the central nervous system

1997 • 403 citations

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1992 • 382 citations

Neuronal Nicotinic Acetylcholine Receptors

1996 • 377 citations

Interleukin 1β inhibits synaptic strength and long-term potentiation in the rat CA1 hippocampus

1993 • 373 citations

Calcium and Excitotoxic Neuronal Injury

1994 • 351 citations

Selective potentiation of NMDA-induced neuronal injury following induction of astrocytic iNOS

1994 • 301 citations

Cell death induction by TNF: a matter of self control

1997 • 231 citations

Interleukin-6 released in human cerebrospinal fluid following traumatic brain injury may trigger nerve growth factor production in astrocytes

1996 • 231 citations

Ceramide Protects Hippocampal Neurons Against Excitotoxic and Oxidative Insults, and Amyloid β‐Peptide Toxicity

1996 • 229 citations

Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor

1995 • 214 citations

Cytokine-mediated Induction of Ceramide Production Is Redox-sensitive

1998 • 206 citations

Localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain

1992 • 195 citations

Early events in TNF signaling: a story of associations and dissociations

1997 • 194 citations

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1993 • 180 citations

Tumor Necrosis Factor-α: a Neuromodulator in the CNS

1997 • 174 citations

TNF Receptor Death Domain-associated Proteins TRADD and FADD Signal Activation of Acid Sphingomyelinase

1998 • 171 citations

Apoptosis mediated by the TNF-related cytokine and receptor families

1996 • 169 citations

Interleukin-6 protects cultured rat hippocampal neurons against glutamate-induced cell death

1994 • 167 citations

Interleukin-1 augments gamma-aminobutyric acidA receptor function in brain.

1991 • 165 citations

Ultrastructural studies of the blood-retina barrier after exposure to interleukin-1 beta or tumor necrosis factor-alpha.

1994 • 147 citations

Reduced long-term potentiation in the dentate gyrus of transgenic mice with cerebral overexpression of interleukin-6

1995 • 145 citations

Interleukin-6 inhibits long-term potentiation in rat hippocampal slices

1997 • 144 citations

Inhibition of NMDA receptor-mediated synaptic transmission in the rat dentate gyrus in vitro by IL-1β

1997 • 113 citations

Current Concepts of Excitotoxicity

1996 • 107 citations

Nicotine blocks TNF-?-mediated neuroprotection to NMDA by an ?-bungarotoxin-sensitive pathway

1998 • 104 citations

Neuronal Expression of Tumor Necrosis Factor Alpha in the OVOUJI fme Brain

1996 • 95 citations

Interleukin‐6 Induces Expression of Peripherin and Cooperates with Trk Receptor Signaling to Promote Neuronal Differentiation in PC12 Cells

1996 • 94 citations

Brain Neurotransmission during Peripheral Inflammation^a

1998 • 86 citations

Transgenic mice and cytokine actions in the brain: bridging the gap between structural and functional neuropathology1Published on the World Wide Web on 21 October 1997.1

1998 • 84 citations

Transgenic Models to Study the Actions of Cytokines in the Central Nervous System

1998 • 80 citations

Structural and Functional Impact of the Transgenic Expression of Cytokines in the CNS^a

1998 • 80 citations

Recovery from Desensitization of Neuronal Nicotinic Acetylcholine Receptors of Rat Chromaffin Cells Is Modulated by Intracellular Calcium through Distinct Second Messengers

1998 • 77 citations

Activation of Acid Sphingomyelinase by Interleukin-1 (IL-1) Requires the IL-1 Receptor Accessory Protein

1997 • 77 citations

Bioactive lipids in excitatory neurotransmission and neuronal plasticity

1997 • 76 citations

Chapter 6 Redox modulation of the NMDA receptor by NO-related species

1998 • 66 citations

A Crucial Role for the Mitogen-Activated Protein Kinase Pathway in Nicotinic Cholinergic Signaling to Secretory Protein Transcription in Pheochromocytoma Cells

1998 • 66 citations

Arachidonic acid lipoxygenation may mediate interleukin‐1 stimulation of nerve growth factor secretion in astroglial cultures

1993 • 50 citations

Selective transport of blood-borne interleukin-1α into the posterior division of the septum of the mouse brain

1995 • 48 citations

Interleukin‐1 Modulates GABAergic and Glutamatergic Function in Braina

1994 • 43 citations

Relative contributions of a CVO and the microvascular bed to delivery of blood-borne IL-1α to the brain

1998 • 43 citations

When cytokines get on your nerves: cytokine networks and CNS pathologies

1996 • 43 citations

Interleukin-1α in the Brain Is Induced by Audiogenic Seizure

1997 • 41 citations

Ceramide, a mediator of interleukin 1, tumour necrosis factor alpha , as well as Fas receptor signalling, induces apoptosis of rheumatoid arthritis synovial cells

1998 • 30 citations

Mechanisms of autoimmune neuropathies

1990 • 27 citations

Activation of Nicotinic Acetylcholine Receptors Augments Calcium Channel-mediated Exocytosis in Rat Pheochromocytoma (PC12) Cells

1998 • 24 citations

Chronic inflammatory effects of interleukin-1 on the blood-retina barrier

1992 • 24 citations

Modulations of Early and Late Secretory Processes by Activation of Protein Kinases in the Rat Adrenal Medulla

1998 • 8 citations